NOAEL Studies
Cosmetic Ingredient
Epichlorohydrin NOAEL Studies
INCI: EPICHLOROHYDRIN
CAS: 106-89-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | SQE9 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"9","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQE9 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"9","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQE9 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"9","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQE9 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"9","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"9","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABmale | listing type | - | - | 1996-09-01 | California Proposition 65 listing | {"cancer_reproductive":"male","listed_date":"1996-09-01","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"9","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABmale | listing type | - | - | 1996-09-01 | California Proposition 65 listing | {"cancer_reproductive":"male","listed_date":"1996-09-01","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"9","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABmale | listing type | - | - | 1996-09-01 | California Proposition 65 listing | {"cancer_reproductive":"male","listed_date":"1996-09-01","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"9","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABmale | listing type | - | - | 1996-09-01 | California Proposition 65 listing | {"cancer_reproductive":"male","listed_date":"1996-09-01","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
EPA_IRIS_iris_rfc_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfc_systems.csv | NOAEL (HEC) | =0.36 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=10e38bacb921e20a; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 3.6e-1 mg/m^3; system=Respiratory; basis=Changes in the nasal turbinates; point_of_departure=NOAEL (HEC): 3.6e-1 mg/m^3; composite_uf=300; confidence=Medium; dtxsid=DTXSID1020566; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=50; rfc_last_updated=04/01/1992; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0050_summary.pdf |
| EPA_IRIS_iris_rfc_systems.csv | RfC | =0.001 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=993074345908f19e; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=1e-3; system=Respiratory; basis=Changes in the nasal turbinates; point_of_departure=NOAEL (HEC): 3.6e-1 mg/m^3; composite_uf=300; confidence=Medium; dtxsid=DTXSID1020566; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=50; rfc_last_updated=04/01/1992; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0050_summary.pdf |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2A | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"NB Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data; volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"11, Sup 7, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 2A | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"NB Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data; volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"11, Sup 7, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 2A | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"NB Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data; volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"11, Sup 7, 71"} |
NTP_ICE_acute_inhalation 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 0.9454 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=760; Record_ID=acute_inhalation_1099; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.9454; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 8.9588 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=761; Record_ID=acute_inhalation_1898; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=8.9588; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 1.3614 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=762; Record_ID=acute_inhalation_1920; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.3614; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 3 | mg/L | - | Inhalation | Duration=2 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=763; Record_ID=acute_inhalation_1601; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=3; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 0.96 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=764; Record_ID=acute_inhalation_1922; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.96; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 3.073 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=765; Record_ID=acute_inhalation_1926; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=3.073; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 13.6784 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=766; Record_ID=acute_inhalation_2578; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=13.6784; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 8.1874 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=767; Record_ID=acute_inhalation_1893; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=8.1874; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 10.5812 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=769; Record_ID=acute_inhalation_1895; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=10.5812; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 1.8908 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=770; Record_ID=acute_inhalation_1896; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.8908; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 2.4 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=771; Record_ID=acute_inhalation_1900; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.4; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 2.4014 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=772; Record_ID=acute_inhalation_1902; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.4014; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 2.2 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=773; Record_ID=acute_inhalation_1905; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.2; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 2.2009 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=774; Record_ID=acute_inhalation_1908; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.2009; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 2.8022 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=775; Record_ID=acute_inhalation_1910; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.8022; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 1.5543 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=776; Record_ID=acute_inhalation_1915; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.5543; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_acute_inhalation | LC50 | 2.1934 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=777; Record_ID=acute_inhalation_1918; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.1934; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
NTP_ICE_acute_oral 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =40 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_582; row=2062; data_type=In Vivo; mixture=Chemical; chemical_name=Epichlorohydrin; preferred_name=Epichlorohydrin; dtxsid=DTXSID1020566; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020566; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =90 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_583; row=2063; data_type=In Vivo; mixture=Chemical; chemical_name=Epichlorohydrin; preferred_name=Epichlorohydrin; dtxsid=DTXSID1020566; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020566; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =175 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_585; row=2064; data_type=In Vivo; mixture=Chemical; chemical_name=Epichlorohydrin; preferred_name=Epichlorohydrin; dtxsid=DTXSID1020566; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020566; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =210 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_587; row=2065; data_type=In Vivo; mixture=Chemical; chemical_name=Epichlorohydrin; preferred_name=Epichlorohydrin; dtxsid=DTXSID1020566; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020566; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =218 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_589; row=2066; data_type=In Vivo; mixture=Chemical; chemical_name=Epichlorohydrin; preferred_name=Epichlorohydrin; dtxsid=DTXSID1020566; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020566; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =282 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_591; row=2067; data_type=In Vivo; mixture=Chemical; chemical_name=Epichlorohydrin; preferred_name=Epichlorohydrin; dtxsid=DTXSID1020566; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020566; source_file=acute_oral.xlsx |
NTP_ICE_cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=1303; Record_ID=cancer_2948; Data_Type=WOE; Formulation_Name=Epichlorohydrin; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2A; Response_Unit=Unitless; URL=http://publications.iarc.fr/29; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_cancer | Inhalation risk unit | 0.0000012 | ug/m3 | - | Inhalation | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=1298; Record_ID=cancer_2950; Data_Type=WOE; Formulation_Name=Epichlorohydrin; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=IRIS Carcinogenicity; Endpoint=Inhalation risk unit; Response=1.1999999999999999E-6; Response_Unit=ug/m3; Route=Inhalation; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0050_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
| NTP_ICE_cancer | Oral slope factor | 0.0099 | mg/kg bw/day | - | Oral | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=1301; Record_ID=cancer_2951; Data_Type=WOE; Formulation_Name=Epichlorohydrin; Mixture=Chemical; DTXSID=DTXSID1020566; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=9.9000000000000008E-3; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0050_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020566; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020566 |
ToxValDB_Cal_OEHHA_REL_derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Cal_OEHHA_REL_derivations | LOAEL | =75.6814 | mg/m3 | Human | inhalation | acute; 1 hours | occupational | LONG_REF=(NIOSH) National Institute for Occupational Safety and Health. Criteria for a recommended standard: occupational exposure to epichlorohydrin. Cincinnati: DHEW (NIOSH); 1976;76-202; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=irritation of eyes and nasal passages; STUDY_GROUP=Cal OEHHA REL derivations:15951924:-:-occupationally exposed workers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2179c75f10d811a50ac2b83c5025caa1 |
| ToxValDB_Cal_OEHHA_REL_derivations | NOAEL | =18.9203 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=Quast JF, Henck JW, Postma BJ, Schuetz DJ, and McKenna MJ. 1979. Epichlorohydrin - subchronic studies. I. A 90-day inhalation study in laboratory rodents. Toxicology Research Laboratory, Dow Chemical U.S.A., Midland, MI (unpublished); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Inflammation, focal erosions, hyperplasia, and metaplasia in the nasal turbinates; STUDY_GROUP=Cal OEHHA REL derivations:15952046:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_499b6b41e23e1771d35a3c7f671b504d |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =143795 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=DOE Protective Action Criteria:15515156:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e4e2e031e4358f0cf0a57944768b9aa1 |
ToxValDB_ECHA_IUCLID 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =12.5 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/9/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855408_15856730:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fcf403f2095423634c15200a89a3546d |
| ToxValDB_ECHA_IUCLID | LOAEC | =113.522 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215ea9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/8?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817374_15817375:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_23cc150acefff67d01a28aceeffe940c |
| ToxValDB_ECHA_IUCLID | LOAEL | >=7 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a9f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/6/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837193_15837194:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_efcf0362573a5c9c54ba331272a2dbec |
| ToxValDB_ECHA_IUCLID | LOAEL | =3.3 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55bf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/9/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15856996:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e716115f80b004d3dd137c54d088bba |
| ToxValDB_ECHA_IUCLID | NOAEC | =83.625 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cb8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/8?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15817513:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ebf83ef0aeca24240fe7ab9164cd9691 |
| ToxValDB_ECHA_IUCLID | NOAEC | >94.6017 | mg/m3 | Rabbit | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ec84; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/9/3?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821665:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ca2afb06afd1c2e187ba0787efbe091 |
| ToxValDB_ECHA_IUCLID | NOAEC | =18.9203 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c884e4b0a7c65d218faa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/9/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15855555:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_91ff684504716ad0fa7fb79de442823a |
| ToxValDB_ECHA_IUCLID | NOAEC | =189.203 | mg/m3 | Rabbit | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c884e4b0a7c65d218fc7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/9/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855766_15856524:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_75a550e4003e48146e13519b3c4fe6ed |
| ToxValDB_ECHA_IUCLID | NOAEL | >94.6017 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ec6e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/9/3?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15820943:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fd391a61298bfa8db7c776f85042338 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=3 | mg/kg bw/day | Rat | oral | short-term; 10 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a9f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/6/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837191_15837192:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_353aaca8a4bc9b197531fbedc59536bf |
| ToxValDB_ECHA_IUCLID | NOAEL | =1 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a9f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/6/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15837195:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1d21b8997d4cf6b3b724bfc5402587dd |
| ToxValDB_ECHA_IUCLID | NOAEL | =25 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/9/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855408_15856730:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_517d5ab6ba1439e67534076932867835 |
| ToxValDB_ECHA_IUCLID | NOAEL | >100 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/9/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15856227:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e65d0e492629ab53bd596f4a26a3778a |
| ToxValDB_ECHA_IUCLID | NOAEL | =50 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/9/2?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15859388:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_554d3936362e0b6d4ca5fa3b9a04997a |
| ToxValDB_ECHA_IUCLID | NOEC | =37.8407 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215ea9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1262/7/8?documentUUID=847b5f50-7695-42bc-91d4-8e80a8850bc3; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817374_15817375:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ba8d777d878e976e7d8b1a59d91b5ba |
ToxValDB_EPA_TSCA_8e 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_TSCA_8e | LEL | =31407.8 | mg/m3 | Mouse | inhalation | acute; 30 minutes | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920009884_106898_7F5EF9570C1734E585256930004F0862.pdf; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=mortality; STUDY_GROUP=EPA TSCA 8e:15957150:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1dc9024b5b531b69b13d373bc9e44c28 |
| ToxValDB_EPA_TSCA_8e | LEL | =946.017 | mg/m3 | Rat | inhalation | acute; 8 hours | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920009884_106898_7F5EF9570C1734E585256930004F0862.pdf; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=mortality; STUDY_GROUP=EPA TSCA 8e:15957152:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1acd844919d97037c5a8841d617b825e |
| ToxValDB_EPA_TSCA_8e | LEL | =0.5 | mL/kg-day | Rat | dermal | short-term | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920009884_106898_7F5EF9570C1734E585256930004F0862.pdf; TOXICOLOGICAL_EFFECT=mortality; STUDY_GROUP=EPA TSCA 8e:15957153:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_51742277ecbb258280d065fce7d17b6f |
| ToxValDB_EPA_TSCA_8e | LEL | =96 | mg/kg bw/day | Mouse | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920009884_106898_7F5EF9570C1734E585256930004F0862.pdf; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=mortality; STUDY_GROUP=EPA TSCA 8e:15957154:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5926506396760b6d6910e140318061ac |
| ToxValDB_EPA_TSCA_8e | LEL | =8968.24 | mg/m3 | Mouse | inhalation | short-term | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920009884_106898_7F5EF9570C1734E585256930004F0862.pdf; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=mortality; STUDY_GROUP=EPA TSCA 8e:15957155:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_53659aa29621eefd753920132c94be69 |
| ToxValDB_EPA_TSCA_8e | NEL | =8968.24 | mg/m3 | Mouse | inhalation | acute; 60 minutes | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920009884_106898_7F5EF9570C1734E585256930004F0862.pdf; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=no mortalities; STUDY_GROUP=EPA TSCA 8e:15957140:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_03a9edf53a9019b1eb6d8024376c5a01 |
ToxValDB_IRIS 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LOAEL | =95 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | LONG_REF=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna. 1979a. Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents. 8D Submission. Microfiche No. 206200.; TITLE=Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents; AUTHOR=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=50; TOXICOLOGICAL_EFFECT=nasal turbinates; STUDY_GROUP=IRIS_dup_IRIS Summary_15644777_15644778_15644779_15644780_15644781_15644782:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_db88bedd429564779497cb2eaacedde3 |
| ToxValDB_IRIS | LOAEL (ADJ) | =17 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | LONG_REF=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna. 1979a. Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents. 8D Submission. Microfiche No. 206200.; TITLE=Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents; AUTHOR=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=50; TOXICOLOGICAL_EFFECT=nasal turbinates; STUDY_GROUP=IRIS_dup_IRIS Summary_15644777_15644778_15644779_15644780_15644781_15644782:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2687d568578707b0854738d32d275a9 |
| ToxValDB_IRIS | LOAEL (HEC) | =1.82 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | LONG_REF=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna. 1979a. Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents. 8D Submission. Microfiche No. 206200.; TITLE=Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents; AUTHOR=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=50; TOXICOLOGICAL_EFFECT=nasal turbinates; STUDY_GROUP=IRIS_dup_IRIS Summary_15644777_15644778_15644779_15644780_15644781_15644782:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3f2c4b6c4c3d8702f33720c307f436a5 |
| ToxValDB_IRIS | NOAEL | =19 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | LONG_REF=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna. 1979a. Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents. 8D Submission. Microfiche No. 206200.; TITLE=Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents; AUTHOR=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=50; TOXICOLOGICAL_EFFECT=nasal turbinates; STUDY_GROUP=IRIS_dup_IRIS Summary_15644777_15644778_15644779_15644780_15644781_15644782:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2ba6fd7f9b5d083b585180179073ff0 |
| ToxValDB_IRIS | NOAEL (ADJ) | =3.4 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | LONG_REF=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna. 1979a. Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents. 8D Submission. Microfiche No. 206200.; TITLE=Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents; AUTHOR=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=50; TOXICOLOGICAL_EFFECT=nasal turbinates; STUDY_GROUP=IRIS_dup_IRIS Summary_15644777_15644778_15644779_15644780_15644781_15644782:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_424e99ca76169ed54897e165293b42e6 |
| ToxValDB_IRIS | NOAEL (HEC) | =0.36 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | LONG_REF=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna. 1979a. Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents. 8D Submission. Microfiche No. 206200.; TITLE=Epichlorohydrin - subchronic studies I. A 90-Day Inhalation Study in Laboratory Rodents; AUTHOR=Quast, J.F., J.W. Henck, B.J. Postma, D.J. Schuetz and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=50; TOXICOLOGICAL_EFFECT=nasal turbinates; STUDY_GROUP=IRIS_dup_IRIS Summary_15644777_15644778_15644779_15644780_15644781_15644782:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e0820745158f26bc11f29a93da08ce5a |
| ToxValDB_IRIS | RfC | =0.001 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Quast et al., 1979a; AUTHOR=Quast et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d04; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=50; TOXICOLOGICAL_EFFECT=Changes in male/female rats; STUDY_GROUP=IRIS:15644783:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_839dc86ad69774c398a0204244a20f06 |
ToxValDB_PPRTV_(CPHEA) 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | LOAEL | =6.25 | mg/kg bw/day | Rat | oral | short-term; 23 days | reproduction developmental | LONG_REF=Toth et al. 1991; AUTHOR=Toth et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1739; TOXICOLOGICAL_EFFECT=fertility effects; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=PPRTV (CPHEA):15653858:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3deae4f662dc4bc9b8b13071552d683b |
| ToxValDB_PPRTV_(CPHEA) | NOAEL (HEC) | =0.32 | mg/m3 | Rat | inhalation | - | subchronic | LONG_REF=Quast et al. 1979; AUTHOR=Quast et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1739; TOXICOLOGICAL_EFFECT=nasal turbinates; STUDY_GROUP=PPRTV (CPHEA):15653584:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_76e516378c2531c61b293e58a23293df |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =0.01 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Quast et al. 1979; AUTHOR=Quast et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1739; TOXICOLOGICAL_EFFECT=Changes in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653583:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_63086025241c783173e677dcf99f0ec8 |
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfD | =0.006 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650094:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6bcc474baf24dfd8fed08aa561e5c9de |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 08OOR508C0 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C3H5ClO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"08OOR508C0"} |
| openFDA substances | FDA UNII substance identifier | 08OOR508C0 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C3H5ClO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"08OOR508C0"} |
| openFDA substances | FDA UNII substance identifier | 08OOR508C0 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C3H5ClO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"08OOR508C0"} |
| openFDA substances | FDA UNII substance identifier | 08OOR508C0 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C3H5ClO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"08OOR508C0"} |