Good Cosmetic Ingredient

Epilobium Angustifolium Flower/Leaf/Stem Extract

INCI: EPILOBIUM ANGUSTIFOLIUM FLOWER/LEAF/STEM EXTRACT

CAS Number
90028-31-2
Function
Skin Conditioning
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No OTC monograph; no CIR final report; no specific FDA restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Epilobium angustifolium flower/leaf/stem extract demonstrates strong in vitro antioxidant (87% DPPH), anti-inflammatory (68.2% lipoxygenase inhibition), and anti-aging (59.8% collagenase inhibition) activity. In vitro cytotoxicity on human dermal fibroblasts indicates a safe upper boundary of ≤0.2% in formulation. Permitted under EU Regulation 1223/2009 with no Annex restrictions.

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Concern Level: Low

Regulatory Flags

plant-extract fireweed willowherb antioxidant anti-inflammatory anti-aging data-gap phenolic-acids

Frequently Asked Questions

Is Epilobium Angustifolium Flower/Leaf/Stem Extract safe in cosmetics?

Epilobium angustifolium flower/leaf/stem extract demonstrates strong in vitro antioxidant (87% DPPH), anti-inflammatory (68.2% lipoxygenase inhibition), and anti-aging (59.8% collagenase inhibition) activity. In vitro cytotoxicity on human dermal fibroblasts indicates a safe upper boundary of ≤0.2% in formulation. Permitted under EU Regulation 1223/2009 with no Annex restrictions. The EU classifies Epilobium Angustifolium Flower/Leaf/Stem Extract as "permitted". Safety rating: GOOD.

Is Epilobium Angustifolium Flower/Leaf/Stem Extract allowed in the EU?

Epilobium Angustifolium Flower/Leaf/Stem Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Epilobium Angustifolium Flower/Leaf/Stem Extract do in cosmetics?

Epilobium Angustifolium Flower/Leaf/Stem Extract functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 90028-31-2.

What is the Margin of Safety for Epilobium Angustifolium Flower/Leaf/Stem Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Epilobium Angustifolium Flower/Leaf/Stem Extract compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
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