Regulatory Status
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Safety Data
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Expert Verdict
Estrogenic activity (ERβ agonist) with endocrine-disruption potential at systemic levels; requires careful use-level justification in CPSR and is not suitable for leave-on products near mucous membranes without MoS calculation.
Regulatory Flags
Frequently Asked Questions
Is Equol safe in cosmetics?
Estrogenic activity (ERβ agonist) with endocrine-disruption potential at systemic levels; requires careful use-level justification in CPSR and is not suitable for leave-on products near mucous membranes without MoS calculation. The EU classifies Equol as "permitted". Safety rating: MODERATE.
Is Equol allowed in the EU?
Equol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Equol do in cosmetics?
Equol functions as: Skin conditioning — antioxidant, estrogen-receptor ligand (ERβ-selective isoflavandiol metabolite of daidzein). It is classified as a cosmetic ingredient in our database. CAS number: 94105-90-5 (racemic); 531-95-3 (S-equol) [^1_1][^1_2].
What is the Margin of Safety for Equol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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