NOAEL Studies
Cosmetic Ingredient
Ethanolamine NOAEL Studies
INCI: ETHANOLAMINE
CAS: 141-43-5 [^1_14]
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >1.3 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3365; Record_ID=acute_inhalation_3536; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1.3; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15808/7/3/3/?documentUUID=d4a813ed-c5d7-4bcf-ad7c-5a557003c259; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
NTP_ICE_acute_oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =2050 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3243; row=10102; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanolamine; preferred_name=Ethanolamine; dtxsid=DTXSID6022000; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6022000; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1720 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_3242; row=10103; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanolamine; preferred_name=Ethanolamine; dtxsid=DTXSID6022000; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6022000; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =10200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3246; row=10104; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanolamine; preferred_name=Ethanolamine; dtxsid=DTXSID6022000; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6022000; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3320 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3245; row=10105; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanolamine; preferred_name=Ethanolamine; dtxsid=DTXSID6022000; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6022000; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2740 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3244; row=10106; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanolamine; preferred_name=Ethanolamine; dtxsid=DTXSID6022000; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6022000; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=8950; RecordID=ARPathway2016_837; DatasetName=ARPathway2016; DTXSID=DTXSID6022000; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
NTP_ICE_eye_irritation 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 23.3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1794; Record_ID=eye_irritation_192; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=23.3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1795; Record_ID=eye_irritation_192; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_eye_irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1793; Record_ID=eye_irritation_192; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_eye_irritation | Intensity | 0.36 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1797; Record_ID=eye_irritation_1312; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Vitrigel; Endpoint=Intensity; Response=0.36; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1796; Record_ID=eye_irritation_1312; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_eye_irritation | Plateau level | 65.4 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1798; Record_ID=eye_irritation_1312; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Vitrigel; Endpoint=Plateau level; Response=65.40; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
NTP_ICE_skin_irritation 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Breakthrough Time | 23.88 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=4157; Record_ID=skin_irritation_invitro_82; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Corrositex; Endpoint=Breakthrough Time; Response=23.88; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Breakthrough Time | 22.09 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=4159; Record_ID=skin_irritation_invitro_84; Data_Type=In Vitro; Concentration=80; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Corrositex; Endpoint=Breakthrough Time; Response=22.09; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | GHS classification | 1 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1170; Record_ID=skin_irritation_invivo_133; Data_Type=In Vivo; Concentration=>99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=GHS classification; Response=1B; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2002; Not available; https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 10.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4161; Record_ID=skin_irritation_invitro_1967; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=10.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 20.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4167; Record_ID=skin_irritation_invitro_1963; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=20.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 20.2 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4168; Record_ID=skin_irritation_invitro_1965; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=20.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 66.2 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4160; Record_ID=skin_irritation_invitro_1963; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=66.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 105.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4165; Record_ID=skin_irritation_invitro_1965; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=105.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 78.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4166; Record_ID=skin_irritation_invitro_1967; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=78.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 67.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4169; Record_ID=skin_irritation_invitro_1967; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=67.40; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 40.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4170; Record_ID=skin_irritation_invitro_1963; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=40.30; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 52.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4171; Record_ID=skin_irritation_invitro_1965; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022000; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=52.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022000; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6022000 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =74950.1 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15515236:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71de229499ef14dcf14e90b3fa0b67d0 |
ToxValDB_ECHA_IUCLID 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =450 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bcdc4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14411/7/9/3?documentUUID=7d2b74ff-0044-4bed-8bd6-bb99dd8eb7cf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECHA IUCLID:15820579:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dae3118f904c58cfb0875cee41c87f4f |
| ToxValDB_ECHA_IUCLID | NOAEL | =225 | mg/kg bw/day | Rat | dermal | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1c1e4b0a7c65d22ff99; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14411/7/9/3?documentUUID=7d2b74ff-0044-4bed-8bd6-bb99dd8eb7cf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820638:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d25e7ae35352069c812b9dc8ea26a86 |
| ToxValDB_ECHA_IUCLID | NOAEL | =75 | mg/kg bw/day | Rabbit | dermal | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1c1e4b0a7c65d22ffa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14411/7/9/3?documentUUID=7d2b74ff-0044-4bed-8bd6-bb99dd8eb7cf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821465:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_78fa7c66aebce9767d6a9bce96fa657d |
| ToxValDB_ECHA_IUCLID | NOAEL | >=97.5 | mg/kg bw/day | Dog | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadc7e4b0a7c65d1c5dfe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14411/7/6/2?documentUUID=7d2b74ff-0044-4bed-8bd6-bb99dd8eb7cf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15830755:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f24a8703bfdcc00aaaa79e0cbd0639a |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Rat | oral | subchronic; 75 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadc7e4b0a7c65d1c5e06; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14411/7/6/2?documentUUID=7d2b74ff-0044-4bed-8bd6-bb99dd8eb7cf; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15834863:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_90f2603d4ad6cce57c327fb9b541a507 |
| ToxValDB_ECHA_IUCLID | NOAEL | =320 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadc7e4b0a7c65d1c5e0a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14411/7/6/2?documentUUID=7d2b74ff-0044-4bed-8bd6-bb99dd8eb7cf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15845100:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_74862f8930e2085a627b9b0f25723598 |
ToxValDB_EU_SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EU_SCOEL | LOAEL | =12.4917 | mg/m3 | Rat | inhalation | - | short-term | LONG_REF=Weeks, M.H., Downing, T.O., Musselman, N.P., Carson, T.R. and Groff, W.A. (1960). The effect of continuous exposure of animals to ethanolamine vapour. Am. Ind. Hyg. Ass. J. 21 , 374-381.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d3995; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/022_2-aminoethanol_oel_en.pdf; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=behavioural effects; STUDY_GROUP=EU SCOEL:15952262:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_48e87f90357fc49fd4197a13ef8f1c5c |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =0.51 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629739_15629740:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6daf665d29fcffee2d634ce3bd164d16 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629739_15629740:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fd372813bc00389b5ef814b5d8b6c107 |
ToxValDB_TX_TCEQ 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_TX_TCEQ | LOAEL | =5 | ppm | Rat | - | subchronic; 40 days | subchronic | LONG_REF=Weeks, M. H., Downing, T. O., Musselman, N. P., Carson, T. R., & Groff, W. A. (1960). The effects of continuous exposure of animals to ethanolamine vapor. Am Ind Hyg Assoc J, 21, 374-381. doi: 10.1080/00028896009344089; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5adf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/monoethanolamine.pdf; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=Neurobehavioral effects/CNS depression; STUDY_GROUP=TX TCEQ:15954557:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9daa7909e947c53b6955bce0c1158e06 |
| ToxValDB_TX_TCEQ | NOAEL | =29.98 | mg/m3 | Dog | inhalation | subchronic; 60 days | subchronic | LONG_REF=Weeks, M. H., Downing, T. O., Musselman, N. P., Carson, T. R., & Groff, W. A. (1960). The effects of continuous exposure of animals to ethanolamine vapor. Am Ind Hyg Assoc J, 21, 374-381. doi: 10.1080/00028896009344089; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5adf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/monoethanolamine.pdf; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=Nasal irritation symptoms; STUDY_GROUP=TX TCEQ_dup_-_15954558_15954559:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b7fdfe2708783bf507676ac29f2400e |