NOAEL Studies Cosmetic Ingredient

Ethyl Formate NOAEL Studies

INCI: ETHYL FORMATE

CAS: 109-94-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 119 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 28.95 mg/L - Inhalation - In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=3702; Record_ID=acute_inhalation_3538; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6040117; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=28.95; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040117; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6040117
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1850 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_882; row=10779; data_type=In Vivo; mixture=Chemical; chemical_name=Ethyl formate; preferred_name=Ethyl formate; dtxsid=DTXSID6040117; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040117; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6040117; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =4290 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_883; row=10778; data_type=In Vivo; mixture=Chemical; chemical_name=Ethyl formate; preferred_name=Ethyl formate; dtxsid=DTXSID6040117; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040117; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6040117; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3391; Record_ID=skin_sensitization_invivo_858; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6040117; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80095-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040117; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6040117
NTP_ICE_skin_sensitization Induction dose per skin area 2700 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3389; Record_ID=skin_sensitization_invivo_858; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6040117; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80095-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040117; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6040117
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3395; Record_ID=skin_sensitization_invivo_858; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6040117; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80095-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040117; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6040117
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =84835.3 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15515323:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_501808667b1c73c25e80f2d13f26e97c
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =11 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631997:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_61f21d845464420cba46d8660eea5b6f
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0K3E2L5553 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0K3E2L5553"}
openFDA substances FDA UNII substance identifier 0K3E2L5553 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0K3E2L5553"}
openFDA substances FDA UNII substance identifier 0K3E2L5553 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0K3E2L5553"}
openFDA substances FDA UNII substance identifier 0K3E2L5553 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0K3E2L5553"}