NOAEL Studies
Preservative
Ethylparaben NOAEL Studies
INCI: ETHYLPARABEN
CAS: 120-47-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1030 | mg/kg bw/day | Rat | - | 56 days | subchronic | EFSA AFC - 2004 - OutputID 309 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) - doi:10.2903/j.efsa.2004.83 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1043 | mg/kg bw/day | Rat | - | 56 days | subchronic | EFSA AFC - 2004 - OutputID 309 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) - doi:10.2903/j.efsa.2004.83 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1043 | mg/kg bw/day | Rat | - | 56 days | subchronic | EFSA AFC - 2004 - OutputID 309 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) - doi:10.2903/j.efsa.2004.83 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1030 | mg/kg bw/day | Rat | - | 56 days | subchronic | EFSA AFC - 2004 - OutputID 309 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) - doi:10.2903/j.efsa.2004.83 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1043 | mg/kg bw/day | Rat | - | 56 days | subchronic | EFSA AFC - 2004 - OutputID 309 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) - doi:10.2903/j.efsa.2004.83 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | <=10 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA AFC - 2004 - OutputID 309 - Consumers - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) - doi:10.2903/j.efsa.2004.83 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | <=10 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA AFC - 2004 - OutputID 309 - Consumers - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) - doi:10.2903/j.efsa.2004.83 |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =11000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1612; row=15497; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylparaben; preferred_name=Ethylparaben; dtxsid=DTXSID9022528; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =4300 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1610; row=15498; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylparaben; preferred_name=Ethylparaben; dtxsid=DTXSID9022528; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >3100 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1608; row=15499; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylparaben; preferred_name=Ethylparaben; dtxsid=DTXSID9022528; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 57.24 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3572; Record_ID=adme_parameters_272; Data_Type=Measured; DTXSID=DTXSID9022528; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=57.24; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_adme_parameters | Clint | 126 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=3575; Record_ID=adme_parameters_272; Data_Type=Measured; DTXSID=DTXSID9022528; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=126.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_adme_parameters | Fu | 0.1057 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=3573; Record_ID=adme_parameters_272; Data_Type=Measured; DTXSID=DTXSID9022528; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.1057; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_adme_parameters | Fu | 0.1275 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=3574; Record_ID=adme_parameters_272; Data_Type=Measured; DTXSID=DTXSID9022528; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.1275; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
NTP_ICE_endocrine 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 26.8229513775814 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=9192; RecordID=ERPathway2016_251; DatasetName=ERPathway2016; DTXSID=DTXSID9022528; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=26.8229513775814; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | AC50/EC50/IC50 | 111000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13125; Record_ID=endocrine_invitro_4070; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9022528; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=111000; Reported_Response_Unit=nM; Response=111000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ermler et al. 2011; 21945941; 10.1016/j.taap.2011.09.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | AC50/EC50/IC50 | 100000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13126; Record_ID=endocrine_invitro_4071; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9022528; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=100000; Reported_Response_Unit=nM; Response=100000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | ACC | 12.7721629015894 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=9193; RecordID=ERPathway2016_251; DatasetName=ERPathway2016; DTXSID=DTXSID9022528; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=12.7721629015894; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | EC50 | 24800 | nM | - | - | - | In Vitro; ER Transactivation-Agonist (VM7Luc Assay) | sheet=Data_invitro; excel_row=16602; Record_ID=endocrine_invitro_4473; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9022528; Assay=ER Transactivation-Agonist (VM7Luc Assay); Endpoint=EC50; Reported_Response=2.48E-5; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=24800; Converted_Response_Unit=nM; Response=24800; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | IC01 | 39800 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13011; Record_ID=endocrine_invitro_4029; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9022528; Assay=AR Transactivation-Antagonist; Endpoint=IC01; Reported_Response=39800; Reported_Response_Unit=IC01 (nM); Response=39800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | LOEL | 180 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=773; Record_ID=endocrine_invivo_41; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9022528; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=180; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=180; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Lemini et al. 2003; 15697177; 10.1191/0748233703th177oa|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=9188; RecordID=ARPathway2016_668; DatasetName=ARPathway2016; DTXSID=DTXSID9022528; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | Model Score | 0.0864 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=9194; RecordID=ERPathway2016_251; DatasetName=ERPathway2016; DTXSID=DTXSID9022528; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0864; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | Relative potency | 52 | % | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=15152; Record_ID=endocrine_invitro_4179; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9022528; Assay=AR Transactivation-Antagonist; Endpoint=Relative potency; Reported_Response=52; Reported_Response_Unit=%; Response=52; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Orton et al. 2014; 24055644; 10.1016/j.taap.2013.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
| NTP_ICE_endocrine | Uterine weight increase vs control | 98 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=2238; Record_ID=endocrine_invivo_41; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9022528; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=98; Response_Unit=%; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=180; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Lemini et al. 2003; 15697177; 10.1191/0748233703th177oa|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022528 |
ToxValDB_ECHA_IUCLID 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =4000 | mg/kg bw/day | Rabbit | oral | short-term; 2 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca35e4b0a7c65d220b70; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/6/2?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID:15837611:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_12e513c40fdab952aaaa0a9d57072eba |
| ToxValDB_ECHA_IUCLID | NOAEL | >300 | mg/kg bw/day | Hamster | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d199e4b0a7c65d22f3db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/9/3?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID:15821372:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7639dae1dd57a5dc2fa5350646633ef4 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=1000 | mg/kg bw/day | Dog | oral | short-term; 8 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca35e4b0a7c65d220b6c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/6/2?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID:15832084:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af98120cbfca2d78dd7158757a9403ac |
| ToxValDB_ECHA_IUCLID | NOAEL | >=900 | mg/kg bw/day | Rat | oral | subchronic; 12 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d98; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/6/2?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846778_15850488:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec56c30d33cc61a4ebb700b321f76e64 |
| ToxValDB_ECHA_IUCLID | NOAEL | <=1200 | mg/kg bw/day | Rat | oral | subchronic; 12 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d98; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/6/2?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846778_15850488:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b1399dfc8fba8b71fa15169eea69f012 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1043 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d94; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/9/2?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID:15862561:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d1a19b293c013b1f2073811396b89b7c |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =2000 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15600712:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=20d52e4b72e55cd138288a315e745c7a |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =1043 | mg/kg bw/day | Rat | oral | subchronic; 8 weeks | subchronic | LONG_REF=EFSA AFC (2004). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). doi:10.2903/j.efsa.2004.83.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219); AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2004.83; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614257:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dd913028fb0142ea6b8329ae013a78b9 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =173 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632048:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4459053c6f48d53defd050dc2e1bb530 |
ToxValDB_Uterotrophic_Hershberger_DB 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Uterotrophic_Hershberger_DB | LEL | =6 | mg/kg bw/day | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713497_15713526_15713581:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_04081e74b7894465cf8e60cfba6e2b05 |
| ToxValDB_Uterotrophic_Hershberger_DB | LEL | =18 | mg/kg bw/day | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713497_15713526_15713581:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e74ad237dc5fc96db937483771000ac |
| ToxValDB_Uterotrophic_Hershberger_DB | LEL | =60 | mg/kg bw/day | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713497_15713526_15713581:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f9eee0aee0a9067bc43f20f97ae9f628 |
| ToxValDB_Uterotrophic_Hershberger_DB | LEL | =180 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713629:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b390ccb01a3a28aaff891ec7237b4cfd |
ToxValDB_WHO_JECFA_ADI 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | <=10 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afdc8e4b0d99f5a87effd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/371; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=WHO JECFA ADI:15715478:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_79a7a41548e513bd163c746b87ad5db1 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 14255EXE39 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"14255EXE39"} |
| openFDA substances | FDA UNII substance identifier | 14255EXE39 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"14255EXE39"} |
| openFDA substances | FDA UNII substance identifier | 14255EXE39 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"14255EXE39"} |
| openFDA substances | FDA UNII substance identifier | 14255EXE39 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"14255EXE39"} |