Regulatory Status
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Safety Data
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Expert Verdict
Excavatolide B is a research compound from gorgonian coral with no cosmetic safety dossier, raising significant regulatory gaps; pharmacological activity (COX-2/iNOS inhibition) and potential systemic exposure concerns require comprehensive toxicological data (genotox, repeat-dose, reproductive tox, dermal irritation/sensitization) before CPSR submission, and sourcing has CITES/Nagoya Protocol implications.
Regulatory Flags
Frequently Asked Questions
Is Excavatolide B safe in cosmetics?
Excavatolide B is a research compound from gorgonian coral with no cosmetic safety dossier, raising significant regulatory gaps; pharmacological activity (COX-2/iNOS inhibition) and potential systemic exposure concerns require comprehensive toxicological data (genotox, repeat-dose, reproductive tox, dermal irritation/sensitization) before CPSR submission, and sourcing has CITES/Nagoya Protocol implications. The EU classifies Excavatolide B as "permitted". Safety rating: POOR.
Is Excavatolide B allowed in the EU?
Excavatolide B EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Excavatolide B do in cosmetics?
Excavatolide B functions as: Anti-inflammatory (experimental); inhibits iNOS, COX-2, MMP-9. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned for cosmetic use — research compound from *Briareum excavatum* coral.
What is the Margin of Safety for Excavatolide B?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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