NOAEL Studies Cosmetic Ingredient

Farnesol NOAEL Studies

INCI: FARNESOL

CAS: 4602-84-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 266 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=d43791b8-05ad-4f00-a137-dbafb62b183b_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=d43791b8-05ad-4f00-a137-dbafb62b183b/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=body weight and weight gain; key_result=true; entry_uuid=b061dbfa-3848-4653-81da-ec8b2342878f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 105 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=d43791b8-05ad-4f00-a137-dbafb62b183b_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=d43791b8-05ad-4f00-a137-dbafb62b183b/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=body weight and weight gain; key_result=true; entry_uuid=0407110b-219e-4083-b610-0bf81eb61def
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >758 mg/kg bw/day rat oral: feed - screening for reproductive / developmental toxicity dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=reproductive function (sperm measures); key_result=true; entry_uuid=d714a047-3bbc-4508-930b-b65e24224c13
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >705 mg/kg bw/day rat oral: feed - screening for reproductive / developmental toxicity dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=reproductive performance; key_result=true; entry_uuid=ff815ba8-4a63-4406-b0b2-bcb487f5fe4f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL ca.340 mg/kg bw/day rat oral: feed - screening for reproductive / developmental toxicity dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=other:; key_result=true; entry_uuid=2803932c-0c7e-45a9-ba43-c31fe1bd0570
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 266 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=d43791b8-05ad-4f00-a137-dbafb62b183b_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=d43791b8-05ad-4f00-a137-dbafb62b183b/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=body weight and weight gain; key_result=true; entry_uuid=b061dbfa-3848-4653-81da-ec8b2342878f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 105 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=d43791b8-05ad-4f00-a137-dbafb62b183b_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=d43791b8-05ad-4f00-a137-dbafb62b183b/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=body weight and weight gain; key_result=true; entry_uuid=0407110b-219e-4083-b610-0bf81eb61def
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >758 mg/kg bw/day rat oral: feed - screening for reproductive / developmental toxicity dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=reproductive function (sperm measures); key_result=true; entry_uuid=d714a047-3bbc-4508-930b-b65e24224c13
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >705 mg/kg bw/day rat oral: feed - screening for reproductive / developmental toxicity dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=reproductive performance; key_result=true; entry_uuid=ff815ba8-4a63-4406-b0b2-bcb487f5fe4f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL ca.340 mg/kg bw/day rat oral: feed - screening for reproductive / developmental toxicity dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=other:; key_result=true; entry_uuid=2803932c-0c7e-45a9-ba43-c31fe1bd0570
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 266 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=d43791b8-05ad-4f00-a137-dbafb62b183b_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=d43791b8-05ad-4f00-a137-dbafb62b183b/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=body weight and weight gain; key_result=true; entry_uuid=b061dbfa-3848-4653-81da-ec8b2342878f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 105 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=d43791b8-05ad-4f00-a137-dbafb62b183b_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=d43791b8-05ad-4f00-a137-dbafb62b183b/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=body weight and weight gain; key_result=true; entry_uuid=0407110b-219e-4083-b610-0bf81eb61def
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >758 mg/kg bw/day rat oral: feed - screening for reproductive / developmental toxicity dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=reproductive function (sperm measures); key_result=true; entry_uuid=d714a047-3bbc-4508-930b-b65e24224c13
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >705 mg/kg bw/day rat oral: feed - screening for reproductive / developmental toxicity dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=reproductive performance; key_result=true; entry_uuid=ff815ba8-4a63-4406-b0b2-bcb487f5fe4f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL ca.340 mg/kg bw/day rat oral: feed - screening for reproductive / developmental toxicity dossier=749322f3-32c9-45c9-bd33-b7a751d995d1.i6z; document=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75_749322f3-32c9-45c9-bd33-b7a751d995d1.i6d; document_key=e65e6ff6-3bb6-4b7b-ba2c-2b3acf71af75/749322f3-32c9-45c9-bd33-b7a751d995d1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-13; basis=other:; key_result=true; entry_uuid=2803932c-0c7e-45a9-ba43-c31fe1bd0570
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx ADI =0.8 mg/kg bw/day Consumers - - ADI CHEMASSESS_ID 1065258; HAZARD_ID 19456 - OP_ID 3419 - EFSA PPR - 2020 - Peer review of the pesticide risk assessment of the active substance ferric pyrophosphate - doi:10.2903/j.efsa.2020.5986
NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >17742 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6587; row=5977; data_type=In Vivo; mixture=Chemical; chemical_name=Farnesol; preferred_name=Farnesol; dtxsid=DTXSID3032389; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =6000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_6586; row=5978; data_type=In Vivo; mixture=Chemical; chemical_name=Farnesol; preferred_name=Farnesol; dtxsid=DTXSID3032389; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6585; row=5979; data_type=In Vivo; mixture=Chemical; chemical_name=Farnesol; preferred_name=Farnesol; dtxsid=DTXSID3032389; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389; source_file=acute_oral.xlsx
NTP_ICE_endocrine 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 82.29832096 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=9274; RecordID=ARPathway2016_179; DatasetName=ARPathway2016; DTXSID=DTXSID3032389; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=82.29832096; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_endocrine AC50 23.3014235771792 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9280; RecordID=ERPathway2016_361; DatasetName=ERPathway2016; DTXSID=DTXSID3032389; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=23.3014235771792; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_endocrine ACC 69.24006543 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=9275; RecordID=ARPathway2016_179; DatasetName=ARPathway2016; DTXSID=DTXSID3032389; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=69.24006543; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_endocrine ACC 25.1957181337932 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9281; RecordID=ERPathway2016_361; DatasetName=ERPathway2016; DTXSID=DTXSID3032389; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=25.1957181337932; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_endocrine Model Score 0.0413 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9276; RecordID=ARPathway2016_179; DatasetName=ARPathway2016; DTXSID=DTXSID3032389; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0413; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=9277; RecordID=ARPathway2016_179; DatasetName=ARPathway2016; DTXSID=DTXSID3032389; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_endocrine Model Score 0.0162 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=9282; RecordID=ERPathway2016_361; DatasetName=ERPathway2016; DTXSID=DTXSID3032389; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0162; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization 41 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 21 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1722; Record_ID=skin_sensitization_invitro_424; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=21; Reported_Response_Unit=ug/mL; Response=21; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization CD86, EC150 7.96 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8573; Record_ID=skin_sensitization_invitro_2366; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=7.96; Reported_Response_Unit=ug/mL; Response=7.96; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization CV70 34.36 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8571; Record_ID=skin_sensitization_invitro_2366; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=U-SENS; Endpoint=CV70; Reported_Response=34.36; Reported_Response_Unit=ug/mL; Response=34.36; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization CV75 42.3 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1694; Record_ID=skin_sensitization_invitro_424; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=h-CLAT; Endpoint=CV75; Reported_Response=42.3; Reported_Response_Unit=ug/mL; Response=42.3; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 3.125 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7303; Record_ID=skin_sensitization_invivo_1666; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=3.125; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 2.083 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7315; Record_ID=skin_sensitization_invivo_1667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.083; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 3.75 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7329; Record_ID=skin_sensitization_invivo_1670; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=3.75; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 2.143 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7345; Record_ID=skin_sensitization_invivo_1673; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.143; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 7.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7353; Record_ID=skin_sensitization_invivo_1675; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=7.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Concentration, one positive response 2.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7297; Record_ID=skin_sensitization_invivo_1666; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=2.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Concentration, one positive response 1.667 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7311; Record_ID=skin_sensitization_invivo_1667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1.667; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Concentration, one positive response 1.714 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7341; Record_ID=skin_sensitization_invivo_1673; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1.714; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Concentration, one positive response 6 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7354; Record_ID=skin_sensitization_invivo_1675; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=6; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Depletion Cys 7.3 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=100; Record_ID=skin_sensitization_invitro_22; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=7.3; Reported_Response_Unit=%; Response=7.3; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Depletion Lys 0 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=155; Record_ID=skin_sensitization_invitro_22; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization EC1.5 12.972 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5816; Record_ID=skin_sensitization_invitro_1368; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=12.972; Reported_Response_Unit=uM; Response=12.972; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization EC3 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5818; Record_ID=skin_sensitization_invitro_1368; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=KeratinoSens; Endpoint=EC3; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization EC3 4.1 % Mouse Dermal - In Vivo; Urbisch_SkinSensitization2020; LLNA sheet=Data_invivo; excel_row=12956; Record_ID=skin_sensitization_invivo_2879; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=LLNA; Endpoint=EC3; Response=4.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization IC50 23.31 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5819; Record_ID=skin_sensitization_invitro_1368; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=23.31; Reported_Response_Unit=uM; Response=23.31; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Imax 1.62 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5820; Record_ID=skin_sensitization_invitro_1368; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.62; Reported_Response_Unit=Unitless; Response=1.62; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7285; Record_ID=skin_sensitization_invivo_1664; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Incidence of positive responses 16 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7293; Record_ID=skin_sensitization_invivo_1666; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=16; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Incidence of positive responses 24 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7307; Record_ID=skin_sensitization_invivo_1667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=24; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Incidence of positive responses 28 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7337; Record_ID=skin_sensitization_invivo_1673; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=28; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Incidence of positive responses 8 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7351; Record_ID=skin_sensitization_invivo_1675; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=8; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area 6750 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7283; Record_ID=skin_sensitization_invivo_1664; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area 8100 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7310; Record_ID=skin_sensitization_invivo_1669; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=8100; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area 7776 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7318; Record_ID=skin_sensitization_invivo_1670; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=7776; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area 2865 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7358; Record_ID=skin_sensitization_invivo_1676; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=2865; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area 1529 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=7365; Record_ID=skin_sensitization_invivo_1679; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1529; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2000; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 2109 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7304; Record_ID=skin_sensitization_invivo_1666; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2109; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 1406 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7317; Record_ID=skin_sensitization_invivo_1667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1406; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 2430 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7331; Record_ID=skin_sensitization_invivo_1670; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2430; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 1446 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7347; Record_ID=skin_sensitization_invivo_1673; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1446; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 5062.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7356; Record_ID=skin_sensitization_invivo_1675; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=5062.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 1688 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7301; Record_ID=skin_sensitization_invivo_1666; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=1688; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 1125 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7313; Record_ID=skin_sensitization_invivo_1667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=1125; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 1944 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7327; Record_ID=skin_sensitization_invivo_1670; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=1944; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 1157 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7343; Record_ID=skin_sensitization_invivo_1673; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=1157; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 4050 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7355; Record_ID=skin_sensitization_invivo_1675; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=4050; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7289; Record_ID=skin_sensitization_invivo_1664; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3032389; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640198; 10.1016/j.fct.2008.06.046|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3032389
ToxValDB_ECOTOX 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =750 ug/eu Rat injection short-term; 2 days short-term LONG_REF=J. Invest. Dermatol.113(5): 788-795 Hanley,K., L.G. Komuves, N.M. Bass, S.S. He, Y. Jiang, D. Crumrine, R. Appel, M. Friedman, J. Bettencourt, K. Min, P.M. Fetal Epidermal Differentiation and Barrier Development In Vivo is Accelerated by Nuclear Hormone Receptor Activators 1999; TITLE=Fetal Epidermal Differentiation and Barrier Development In Vivo is Accelerated by Nuclear Hormone Receptor Activators; AUTHOR=Hanley,K., L.G. Komuves, N.M. Bass, S.S. He, Y. Jiang, D. Crumrine, R. Appel, M. Friedman, J. Bettencourt, K. Min, P.M.; DOI=10.1046/j.1523-1747.1999.00743.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97932; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Enzyme(s): steryl-sulfatase|Physiology: Water loss; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15598500:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b31c2480acfad048cc0364cb422fe005
ToxValDB_ECOTOX LOEL =1 mg/kg bw/day European Rabbit injection short-term; 7 days short-term LONG_REF=Eur. J. Pharmacol.418(3): 217-223 Pongo,E., Z. Balla, K. Mubagwa, W. Flameng, I. Edes, Z. Szilvassy, and P. Ferdinandy Deterioration of the Protein Kinase C-KATP Channel Pathway in Regulation of Coronary Flow in Hypercholesterolaemic Rabbits 2001; TITLE=Deterioration of the Protein Kinase C-KATP Channel Pathway in Regulation of Coronary Flow in Hypercholesterolaemic Rabbits; AUTHOR=Pongo,E., Z. Balla, K. Mubagwa, W. Flameng, I. Edes, Z. Szilvassy, and P. Ferdinandy; DOI=10.1016/s0014-2999(01)00954-2; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=98149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Physiology: Diastolic pressure; STUDY_GROUP=ECOTOX:15601891:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=efdbd6523593dcb8c72a74b7fe99ff4b
ToxValDB_ECOTOX LOEL =250 mg/kg bw/day Rat oral subchronic; 56 days subchronic LONG_REF=Carcinogenesis27(6): 1194-1203 Ong,T.P., R. Heidor, A. De Conti, M.L.Z. Dagli, and F.S. Moreno Farnesol and Geraniol Chemopreventive Activities During the Initial Phases of Hepatocarcinogenesis Involve Similar Actions on Cell Proliferation and DNA Damage, but Distinct Actions on Apoptosis, Plasma Cholesterol and 2006; TITLE=Farnesol and Geraniol Chemopreventive Activities During the Initial Phases of Hepatocarcinogenesis Involve Similar Actions on Cell Proliferation and DNA Damage, but Distinct Actions on Apoptosis, Plasma Cholesterol and; AUTHOR=Ong,T.P., R. Heidor, A. De Conti, M.L.Z. Dagli, and F.S. Moreno; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=97936; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Biochemistry: Cholesterol|Cell(s): Cell changes|Genetics: Messenger RNA|Histology: Histological changes, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603616_15605864:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5a5f509097546575935e93712780dcf7
ToxValDB_ECOTOX LOEL =0.34 % Rat oral short-term; 14 days short-term LONG_REF=Biosci. Biotechnol. Biochem.58(1): 211-212 Sugiyama,K., A. Tanaka, H. Kawagishi, F. Ojima, H. Sakamoto, and Y. Ishiguro Hypocholesterolemic Action of Dietary Grifolin on Rats Fed with a High-Cholesterol Diet 1994; TITLE=Hypocholesterolemic Action of Dietary Grifolin on Rats Fed with a High-Cholesterol Diet; AUTHOR=Sugiyama,K., A. Tanaka, H. Kawagishi, F. Ojima, H. Sakamoto, and Y. Ishiguro; DOI=10.1271/bbb.58.211; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98276; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Cholesterol|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605122_15606446:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d738cbff1fb8c2d76505e4625bef56c2
ToxValDB_ECOTOX NOEL =1000 mg/kg bw/day Rat oral short-term; 29 days short-term LONG_REF=Chem.-Biol. Interact.152(2-3): 79-99 Horn,T.L., L. Long, M.J. Cwik, R.L. Morrissey, I.M. Kapetanovic, and D.L. McCormick Modulation of Hepatic and Renal Drug Metabolizing Enzyme Activities in Rats by Subchronic Administration of Farnesol 2005; TITLE=Modulation of Hepatic and Renal Drug Metabolizing Enzyme Activities in Rats by Subchronic Administration of Farnesol; AUTHOR=Horn,T.L., L. Long, M.J. Cwik, R.L. Morrissey, I.M. Kapetanovic, and D.L. McCormick; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=97933; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Cell(s): Red blood cell|Feeding behavior: Food consumption|Growth: Weight|Physiology: Clotting time; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology; STUDY_GROUP=ECOTOX:15596189:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=541081d6cd5c2766e276601a154852ca
ToxValDB_ECOTOX NOEL =500 mg/kg bw/day Rat oral short-term; 29 days short-term LONG_REF=Chem.-Biol. Interact.152(2-3): 79-99 Horn,T.L., L. Long, M.J. Cwik, R.L. Morrissey, I.M. Kapetanovic, and D.L. McCormick Modulation of Hepatic and Renal Drug Metabolizing Enzyme Activities in Rats by Subchronic Administration of Farnesol 2005; TITLE=Modulation of Hepatic and Renal Drug Metabolizing Enzyme Activities in Rats by Subchronic Administration of Farnesol; AUTHOR=Horn,T.L., L. Long, M.J. Cwik, R.L. Morrissey, I.M. Kapetanovic, and D.L. McCormick; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=97933; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Triglycerides|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596564_15596565_15607971:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7d602cc66cec325e8348c99d2fc2b4b9
ToxValDB_ECOTOX NOEL =2 % Mouse injection short-term; 8 days short-term LONG_REF=Redox Rep.10(6): 303-310 Jahangir,T., T.H. Khan, L. Prasad, and S. Sultana Alleviation of Free Radical Mediated Oxidative and Genotoxic Effects of Cadmium by Farnesol in Swiss Albino Mice 2005; TITLE=Alleviation of Free Radical Mediated Oxidative and Genotoxic Effects of Cadmium by Farnesol in Swiss Albino Mice; AUTHOR=Jahangir,T., T.H. Khan, L. Prasad, and S. Sultana; DOI=10.1179/135100005X83671; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=98477; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Enzyme(s): Xanthine oxidase, XOD|Genetics: Chromosomal aberrations; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX:15598813:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5af6261ef10faf294b626d3418ac75c1
ToxValDB_ECOTOX NOEL =30 umol/kg bw European Rabbit oral short-term; 3 days short-term LONG_REF=Eur. J. Pharmacol.353(1): 75-78 Szilvassy,Z., R. Sari, J. Nemeth, I. Nagy, S. Csati, and J. Lonovics Improvement of Nitrergic Relaxation by Farnesol of the Sphincter of Oddi from Hypercholesterolaemic Rabbits 1998; TITLE=Improvement of Nitrergic Relaxation by Farnesol of the Sphincter of Oddi from Hypercholesterolaemic Rabbits; AUTHOR=Szilvassy,Z., R. Sari, J. Nemeth, I. Nagy, S. Csati, and J. Lonovics; DOI=10.1016/s0014-2999(98)00449-x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=98151; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Cyclic guanylic acid; STUDY_GROUP=ECOTOX:15600546:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e820303e869afe7f8eb6202cf0e818ef
ToxValDB_ECOTOX NOEL =5 uM/kg Rat injection acute; 0.0417 days acute LONG_REF=Mol. Cell. Biochem.186(1-2): 27-34 Ferdinandy,P., C. Csonka, T. Csont, Z. Szilvassy, and L. Dux Rapid Pacing-Induced Preconditioning is Recaptured by Farnesol Treatment in Hearts of Cholesterol-Fed Rats: Role of Polyprenyl Derivatives and Nitric Oxide 1998; TITLE=Rapid Pacing-Induced Preconditioning is Recaptured by Farnesol Treatment in Hearts of Cholesterol-Fed Rats: Role of Polyprenyl Derivatives and Nitric Oxide; AUTHOR=Ferdinandy,P., C. Csonka, T. Csont, Z. Szilvassy, and L. Dux; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=98162; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Nitric Oxide concentration|Enzyme(s): Lactate dehydrogenase|Physiology: Aortic flow|Physiology: Diastolic pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15602621:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7fa0f69eacb4a3940e2c0e420ec1f448
ToxValDB_EFSA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA LEL =50 mg/kg bw/day Human oral - epidemiologic LONG_REF=EFSA PPR (2020). Peer review of the pesticide risk assessment of the active substance ferric pyrophosphate. doi:10.2903/j.efsa.2020.5986.; TITLE=Peer review of the pesticide risk assessment of the active substance ferric pyrophosphate; AUTHOR=EFSA PPR; DOI=doi:10.2903/j.efsa.2020.5986; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625503:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ca0d1396ea77fefd0e69502c03624aa
ToxValDB_EFSA NOEC >=0.138 mg/L Zebra Danio inhalation short-term; 30 days short-term LONG_REF=EFSA PPR (2020). Peer review of the pesticide risk assessment of the active substance ferric pyrophosphate. doi:10.2903/j.efsa.2020.5986.; TITLE=Peer review of the pesticide risk assessment of the active substance ferric pyrophosphate; AUTHOR=EFSA PPR; DOI=doi:10.2903/j.efsa.2020.5986; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=growth; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15625504:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d7a14627a3d71f2328c70df3f4ab8dc4
ToxValDB_EFSA NOEC >=111.2 mg/kg bw/day Northern Bobwhite Quail oral - reproduction developmental LONG_REF=EFSA PPR (2020). Peer review of the pesticide risk assessment of the active substance ferric pyrophosphate. doi:10.2903/j.efsa.2020.5986.; TITLE=Peer review of the pesticide risk assessment of the active substance ferric pyrophosphate; AUTHOR=EFSA PPR; DOI=doi:10.2903/j.efsa.2020.5986; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; STUDY_GROUP=EFSA:15625509:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cd3e8261a743a84a7aef890450026696
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.85 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635488:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_843175933f486280d927be2f12cc4135
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier EB41QIU6JL UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"EB41QIU6JL"}
openFDA substances FDA UNII substance identifier EB41QIU6JL UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"EB41QIU6JL"}
openFDA substances FDA UNII substance identifier EB41QIU6JL UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"EB41QIU6JL"}
openFDA substances FDA UNII substance identifier EB41QIU6JL UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"EB41QIU6JL"}