Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Ferrous Fumarate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 800 mg/kg bw/day | oral | dog | Special Toxicology Study | COSMOS_DB |
| NOAEL | 152 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1369 mg/kg bw/day | oral | rabbit | Special Toxicology Study | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS_DB |
| NOAEL | 16 mg/kg bw/day | oral | horse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 1.8 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 1369 mg/kg bw/day | oral | rabbit | Special Toxicology Study | COSMOS_DB |
| dose_tested | 50 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS_DB |
| dose_tested | 1.8 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Oral toxicity risk only at very high oral doses not relevant at cosmetic-use levels; may cause staining; fumarate counterion is GRAS; limited cosmetic-specific dermal safety data despite extensive oral safety history.
Regulatory Flags
Frequently Asked Questions
Is Ferrous Fumarate safe in cosmetics?
Oral toxicity risk only at very high oral doses not relevant at cosmetic-use levels; may cause staining; fumarate counterion is GRAS; limited cosmetic-specific dermal safety data despite extensive oral safety history. The EU classifies Ferrous Fumarate as "prohibited". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Ferrous Fumarate allowed in the EU?
Ferrous Fumarate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ferrous Fumarate do in cosmetics?
Ferrous Fumarate functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 141-01-5.
What is the Margin of Safety for Ferrous Fumarate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ferrous Fumarate?
The NOAEL (No Observed Adverse Effect Level) for Ferrous Fumarate is 800 mg/kg bw/day based on a Special Toxicology Study study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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