Is Ferrous Fumarate safe in cosmetics?
Ferrous Fumarate has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 7 toxicological study endpoint(s) are available in our database.
Ferrous Fumarate
Also known as: EINECS 205-447-7, Erco-Fer, Ercoferro, Feostat, Feroton (+15 more)
INCI: FERROUS FUMARATE
Ferrous Fumarate (CAS 141-01-5) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 141-01-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ferrous Fumarate is prohibited in EU cosmetics but has active industrial GHS classifications (H412).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(E)-but-2-enedioate;iron(2+)
InChIKey
PMVSDNDAUGGCCE-TYYBGVCCSA-L
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted; FDA-approved OTC drug active ingredient (oral iron supplement); no specific cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ferrous Fumarate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Ferrous Fumarate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 16 mg/kg bw/day | oral | horse | Special Toxicology Study | COSMOS DB |
| NOAEL | 50 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS DB |
| NOAEL | 152 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS DB |
| NOAEL | =50 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =160 mg/kg bw/day | oral | Mouse | developmental | ECHA |
| NOAEL | =200 mg/kg bw/day | oral | Rat | developmental | ECHA |
| NOAEL | =400 mg/kg bw/day | oral | Guinea Pig | reproduction developmental | ECHA |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ferrous Fumarate across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =630 mg/kg | Mouse | oral | - | ECHA |
| LD50 | =3850 mg/kg | Rat | oral | - | ECHA |
| LD50 | =2300 mg/kg | Rat | oral | - | ECHA |
| LD50 | =580 mg/kg | Rat | oral | - | ECHA |
| NOAEL | =50 mg/kg-day | Rat | oral | subchronic | ECHA |
| NOAEL | =400 mg/kg-day | Guinea Pig | oral | - | ECHA |
| NOAEL | =400 mg/kg-day | Guinea Pig | oral | - | ECHA |
| NOAEL | =160 mg/kg-day | Mouse | oral | - | ECHA |
| NOAEL | =200 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =200 mg/kg-day | Rat | oral | - | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Ferrous Fumarate.
Regulatory Flags
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ferrous Fumarate by CAS number or substance name.
Studies
7
Lowest NOAEL
16 mg/kg bw/day
Highest NOAEL
400 mg/kg bw/day
COSMOS DB
ECHA
Known Synonyms
EINECS 205-447-7
Erco-Fer
Ercoferro
Feostat
Feroton
Ferrofume
Ferronat
Ferrone
Ferrotemp
Fersamal
Fumafer
Fumar-F
Fumiron
Hemoton
One-iron
Palafer
Toleron
Tolferain
Tolifer
UNII-R5L488RY0Q
Chemical Function
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
Europe; supplements
Europe; food_additive; supplements
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ferrous fumarate
ChEMBL ID
CHEMBL1200640
Adverse Event Associations
2027
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Iron - Ferrous Fumarate
Food Category
vitamins_minerals
Frequently Asked Questions
Is Ferrous Fumarate allowed in the EU?
Ferrous Fumarate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ferrous Fumarate do in cosmetics?
Ferrous Fumarate functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 141-01-5.
What is the NOAEL for Ferrous Fumarate?
The NOAEL (No Observed Adverse Effect Level) for Ferrous Fumarate is 16 mg/kg bw/day based on a Special Toxicology Study study via oral route in horse. A total of 7 study endpoints are available. Source: COSMOS DB.
Is Ferrous Fumarate used outside cosmetics?
Ferrous Fumarate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ferrous Fumarate have different safety status in cosmetics vs industrial chemicals?
Ferrous Fumarate is prohibited in EU cosmetics but has active industrial GHS classifications (H412).
Compliance Tools
Check Ferrous Fumarate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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