NOAEL Studies
Cosmetic Ingredient
Formaldehyde NOAEL Studies
INCI: FORMALDEHYDE
CAS: 50-00-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 32 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =0.491225 | mg/m3 | Human (M/F) | inhalation | acute; 2 hours | clinical | ATSDR MRLs; row_hash=2b858d66face8c78; source_hash=ToxValhc_cf1fbad1107b9e6129b2b99265cec7a0; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=0.4; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Pazdrak, K, Gorski, P, Krakowiak, A and Urszula, R (1993). Changes in Nasal Lavage Fluid Due to Formaldehyde Inhalation. Int Arch Occup Environ Health 64: 515-519.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770 |
| Regulatory source | LOAEL | =0.294735 | mg/m3 | Human (unknown) | inhalation | chronic; 1 years | occupational | ATSDR MRLs; row_hash=615a2ac0677c5a26; source_hash=ToxValhc_841fde9e4b22207961a471ca954b8195; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=0.24; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Holmstrom M, Wilhelmsson B, Hellquist H, et al. 1989c. Histological changes in the nasal mucosa in persons occupationally exposed to formaldehyde alone and in combination with wood dust. Acta Otolaryngol (Stockh) 107:120-129.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770 |
| Regulatory source | NOAEL | =1.2035 | mg/m3 | Monkey (Cynomolgus; M) | inhalation | chronic; 26 weeks | chronic | ATSDR MRLs; row_hash=22e6dbde346e24cd; source_hash=ToxValhc_b7d7b46c4a865558144112b38efa6ac1; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=0.98; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Rusch, G, Clary, JJ, Rinehart WE and Bolte, HF (1983). A 26 Week Inhalation Toxicity Study with Formaldehyde in the Monkey, Rat and Hamster. Toxicol Appl Pharmacol 68: 329-343.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770 |
| Regulatory source | NOAEL | =25 | mg/kg/day | Rat (Wistar; M/F) | oral | short-term; 4 weeks | short-term | ATSDR MRLs; row_hash=2d6702b223c90285; source_hash=ToxValhc_50039a1b2b335c71d69bf7afa34958dd; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=25; raw_unit=mg/kg/day; method=drinking water; effect=gastrointestinal; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Til HP, Woutersen RA, Feron VJ, Clary JJ (1988b). Evaluation of the oral toxicity of acetaldehyde and formaldehyde in a 4-week drinking-water study in rats. Fd. Chem. Toxic 26: 447-452.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770 |
| Regulatory source | NOAEL | =15 | mg/kg/day | Rat (Wistar; M) | oral | chronic; 2 years | chronic | ATSDR MRLs; row_hash=e132330c9df6962d; source_hash=ToxValhc_35d04e01cc2a7478f85cff5cd4c4dcf4; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=15; raw_unit=mg/kg/day; method=drinking water; effect=gastrointestinal; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Til HP, Woutersen RA, Feron VJ, Hollanders VHM, Falke HE, Clary JJ (1989). Two-year drinking-water study of formaldehyde in rats. Fd. Chem. Toxic 27: 77-86.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770 |
| Regulatory source | RfC | =0.007 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=5925244717de90e4; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=7e-3; system=Respiratory; basis=Decreased pulmonary function, prevalence of current asthma or degree of asthma control, and allergic conditions in children (See Note); confidence=High; dtxsid=DTXSID7020637; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=419; rfc_last_updated=08/19/2024; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0419_summary.pdf |
| Regulatory source | NOAEL | =15 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=0982973dcdd37fef; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 1.5e1 mg/kg-day; system=Urinary, Gastrointestinal, Other; basis=Reduced weight gain, histopathology in rats; point_of_departure=NOAEL : 1.5e1 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID7020637; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=419; rfd_last_updated=09/01/1990; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0419_summary.pdf |
| Regulatory source | RfD | =0.2 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=7b11f0505ca5c5a1; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2e-1; system=Urinary, Gastrointestinal, Other; basis=Reduced weight gain, histopathology in rats; point_of_departure=NOAEL : 1.5e1 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID7020637; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=419; rfd_last_updated=09/01/1990; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0419_summary.pdf |
| Regulatory source | - | 1 | % | rat | inhalation | 60 weeks | - | p.38 |
| Regulatory source | - | 1 | ppm | rat | inhalation | 26 weeks | - | p.38 |
| Regulatory source | - | 1 | ppm | rat | inhalation | - | - | p.39 |
| Regulatory source | - | 2 | ppm | rat | inhalation | 1 day | - | p.35 |
| Regulatory source | - | 10 | mg/kg bw/day | - | dermal | 12 months | - | p.37 |
| Regulatory source | carcinogenicity | 4 | ppm | mouse | oral | Chronic | carcinogenicity | p.37 |
| Regulatory source | carcinogenicity | 10 | ppm | rat | inhalation | - | carcinogenicity | p.39 |
| Regulatory source | carcinogenicity | 15 | mg/kg bw/day | rat | oral | - | carcinogenicity | p.11 |
| Regulatory source | carcinogenicity | 21 | mg/kg bw/day | rat | oral | chronic | carcinogenicity | p.46 |
| Regulatory source | developmental toxicity | 5 | ppm | rat | inhalation | - | developmental toxicity | p.61 |
| Regulatory source | genotoxicity | 0.3 | ppm | rat | oral | - | genotoxicity | p.10 |
| Regulatory source | genotoxicity | 0.3 | ppm | rat | dermal | - | genotoxicity | p.40 |
| Regulatory source | genotoxicity | 1 | ppm | rat | inhalation | - | genotoxicity | p.40 |
| Regulatory source | irritation | 0.08 | ppm | - | - | - | irritation | p.12 |
| Regulatory source | irritation | 0.5 | ppm | - | - | - | irritation | p.72 |
| Regulatory source | irritation | 0.5 | ppm | human | - | - | irritation | p.73 |
| Regulatory source | irritation | 1 | ppm | rat | inhalation | 13 weeks | irritation | p.36 |
| Regulatory source | irritation | 2 | ppm | mouse | inhalation | 13 weeks | irritation | p.36 |
| Regulatory source | irritation | 25 | mg/kg bw/day | rat | oral | 28 days | irritation | p.33 |
| Regulatory source | irritation | 2012 | - | - | - | - | irritation | p.12 |
| Regulatory source | repeated dose toxicity | 0.5 | ppm | rat | oral | - | repeated dose toxicity | p.10 |
| Regulatory source | repeated dose toxicity | 10 | mg/kg bw/day | rat | oral | - | repeated dose toxicity | p.10 |
| Regulatory source | repeated dose toxicity | 50 | mg/kg bw/day | rat | oral | - | repeated dose toxicity | p.39 |
| Regulatory source | reproductive toxicity | 0.4 | ppm | rat | - | developmental | reproductive toxicity | p.61 |
COSMOS DB 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 82 | mg/kg bw/day | rat | oral | 2 year | Chronic | IRIS;Munro |
| COSMOS DB | NOAEL | 9.4 | mg/kg bw/day | dog | oral | 54 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 20 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 21 | mg/kg bw/day | rat | oral | 2 year | Chronic | IRIS;Munro |
| COSMOS DB | NOAEL | 25 | mg/kg bw/day | rat | oral | 90 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 75 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 95 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | dog | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 125 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 150 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 185 | mg/kg bw/day | mouse | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 250 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 300 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 540 | mg/kg bw/day | mouse | oral | 5 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
California Proposition 65 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | SQE40 | ug/day | - | - | 1988-01-01 | No significant risk level | - |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-01-01 | California Proposition 65 listing | - |
ECHA 64 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | >9.4 | mg/kg bw/day | other: | oral: feed | - | developmental toxicity | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=424f54d4-db45-42a2-b608-260750e11b1b_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=424f54d4-db45-42a2-b608-260750e11b1b/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=false; entry_uuid=1d3b40ac-0844-42f2-ba85-55604e90f311 |
| ECHA | LOAEL | 74 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=295b26d6-49db-4af9-b9d3-3009ab2b977f_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=295b26d6-49db-4af9-b9d3-3009ab2b977f/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1980; basis=body weight and weight gain; key_result=false; entry_uuid=a8ee4cf7-8eca-4911-9b18-4f0f6872c087 |
| ECHA | LOAEL | 50 | mg/kg bw/day | rat | oral: drinking water | - | carcinogenicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=c2f2e120-a991-463f-85d9-583692c26b06_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=c2f2e120-a991-463f-85d9-583692c26b06/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1989; basis=other:; key_result=false; entry_uuid=32a34abb-1fe7-4e86-ae94-9a920b0f9b64 |
| ECHA | NOAEL | 25 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=2cd4ffe0-c951-4669-bbc5-80740c705b09_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=2cd4ffe0-c951-4669-bbc5-80740c705b09/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1989; basis=body weight and weight gain; key_result=false; entry_uuid=5bc5441b-416b-4688-9b82-3b1ca895666c |
| ECHA | NOAEL | 10 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=9590ae69-3030-4a67-a62b-eef042a4ca7b_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=9590ae69-3030-4a67-a62b-eef042a4ca7b/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1989; basis=histopathology: non-neoplastic; key_result=false; entry_uuid=ea28dc0b-82c7-4545-9d2c-df1879359219 |
| ECHA | NOAEL | <=2 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=b8c5377d-9f8c-4db2-bd43-53ac7b9b3401_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=b8c5377d-9f8c-4db2-bd43-53ac7b9b3401/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2017; basis=behaviour (functional findings); key_result=false; upper_value=2; entry_uuid=5871a7f4-b897-4ed5-a2c9-4874e37e30ec |
| ECHA | NOAEL | 82 | mg/kg bw/day | rat | oral: drinking water | - | carcinogenicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=22985779-1a96-4fc6-a315-2f6187e1daec_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=22985779-1a96-4fc6-a315-2f6187e1daec/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1989; basis=other:; key_result=false; entry_uuid=d01e67ad-31ac-4270-94c5-fbbea2dd9bc4 |
| ECHA | NOAEL | 109 | mg/kg bw/day | rat | oral: drinking water | - | carcinogenicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=22985779-1a96-4fc6-a315-2f6187e1daec_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=22985779-1a96-4fc6-a315-2f6187e1daec/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1989; basis=other:; key_result=false; entry_uuid=0e33d5ca-d889-4767-abc8-f2377ddb7be3 |
| ECHA | NOAEL | 15 | mg/kg bw/day | rat | oral: drinking water | - | carcinogenicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=22985779-1a96-4fc6-a315-2f6187e1daec_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=22985779-1a96-4fc6-a315-2f6187e1daec/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1989; basis=other:; key_result=false; entry_uuid=faed6540-21d1-4066-892e-c4d163cdbb70 |
| ECHA | NOAEL | 21 | mg/kg bw/day | rat | oral: drinking water | - | carcinogenicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=22985779-1a96-4fc6-a315-2f6187e1daec_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=22985779-1a96-4fc6-a315-2f6187e1daec/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1989; basis=other:; key_result=false; entry_uuid=91182632-53c3-4ebe-aba2-1268406f5166 |
| ECHA | NOAEL | 185 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=295b26d6-49db-4af9-b9d3-3009ab2b977f_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=295b26d6-49db-4af9-b9d3-3009ab2b977f/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1980; basis=other:; key_result=false; entry_uuid=aea25166-69ea-42bc-b4c5-eeab3bd8328f |
| ECHA | NOAEL | <=20 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=b981d3ea-1d49-4658-8dd9-030e33a93510_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=b981d3ea-1d49-4658-8dd9-030e33a93510/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; basis=histopathology: neoplastic; key_result=false; upper_value=20; entry_uuid=44eaef4b-b611-4021-a8ef-2432329e6329 |
| ECHA | NOAEL | <=50 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=e5eae057-b3ad-418d-b6df-069a8d4a1bde_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=e5eae057-b3ad-418d-b6df-069a8d4a1bde/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=water consumption and compound intake; key_result=false; upper_value=50; entry_uuid=ce3ec85c-daa2-4855-99d4-d986f1b40de4 |
| ECHA | NOAEL | 300 | mg/kg bw/day | rat | oral: drinking water | - | carcinogenicity: oral | dossier=7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6z; document=c2f2e120-a991-463f-85d9-583692c26b06_7d2fc287-88f7-49b3-87a2-258c60a3d6ca.i6d; document_key=c2f2e120-a991-463f-85d9-583692c26b06/7d2fc287-88f7-49b3-87a2-258c60a3d6ca; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1989; basis=other:; key_result=false; entry_uuid=04fc5d61-81e8-4960-b299-e3a8b8e42770 |
| ECHA | LEL | =6.01751 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/3/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15796240:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d59bf26fa95b8636c5a6db84cc0e9f2c |
| ECHA | LEL | =20000 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/3/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15796538_15797704_15798336_15798337:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9150a96fa0d55fe3bc23464df6b15e17 |
| ECHA | LEL | =38.9296 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/3/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797349_15798406:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d435af6067093b6142ca904ea968934 |
| ECHA | LEL | =17000 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/3/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15796538_15797704_15798336_15798337:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c38fdfb5352bf117600dd771c4a63ce |
| ECHA | LEL | =21000 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/3/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15796538_15797704_15798336_15798337:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8efed276c045b033a3fb9e0be906632 |
| ECHA | LEL | =2.45613 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/3/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797349_15798406:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_daedb4db81ff96d8ae499256e0172169 |
| ECHA | LEL | =18.4209 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216dee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15816401:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3926ee041ce65dd754d85eec70cc55cf |
| ECHA | LEL | =5000 | mg/L | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e1e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15817728:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_00c8d00655c780e0b5f6494aecffac11 |
| ECHA | LEL | =12.2806 | mg/m3 | Hamster | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e2a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15818621:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_67cbab781176cfa1662ac6219294fe05 |
| ECHA | LEL | >=6.14032 | mg/m3 | Rat | inhalation | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217e96; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/10/2?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15825475:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a79d7688a64a67ee38edf045ac1f6c6 |
| ECHA | LEL | =7.36838 | mg/m3 | Rat | inhalation | short-term; 4 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827235_15827236:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_65d6c3ab614ded1f488af0276ca47a34 |
| ECHA | LEL | =3.68419 | mg/m3 | Rat | inhalation | short-term; 3 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID:15828517:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f629e57e26ae86bcaebbada229a770cc |
| ECHA | LOAEC | =12.2806 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216dde; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816202_15816203_15817929_15817930:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac0a8378f6df2fc1c5651254c08beaae |
| ECHA | LOAEC | =24.5613 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216dde; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816202_15816203_15817929_15817930:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d5c2effdb25cc5fa1e63bf083a51fb1f |
| ECHA | LOAEC | =7.36838 | mg/m3 | Mouse | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e0c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816514_15816515_15816516:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a29775c2e222caf3c914f9181467f51c |
| ECHA | LOAEC | =2.45613 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e18; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816848_15816849_15816850:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13013a0b89491d7745e3de177d395ed2 |
| ECHA | LOAEC | =2.70174 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e1a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817368_15817369_15817370_15817371_15817944_15817945_15817946_15817947_15819180_15819181:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_580d4bfd441f7e6ee33a6a241cd2a213 |
| ECHA | LOAEC | =0.512102 | mg/m3 | Rat | inhalation | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217e94; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/10/2?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=clinical biochemistry|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15825474:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3dc2f997290cb91a774249f6c28d3409 |
| ECHA | LOAEC | =14.7368 | mg/m3 | Rat | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d218534; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/10/1?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=neurons: neuropathology; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825898_15825899:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_08c81c5e397de4a365f1d905908c4598 |
| ECHA | LOAEC | =0.0982451 | mg/m3 | Mouse | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d21853e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/10/1?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825928_15825971:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1c7cb83af5e635b42193bea0296b1a47 |
| ECHA | LOAEC | =3.68419 | mg/m3 | Monkey | inhalation | chronic; 26 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fa0e4b096bca877e346; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15826952_15826953:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_21e7c4ac8e80ea6e11724e5ede4ac6a7 |
| ECHA | LOAEC | =4.91225 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828225_15828226:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2f040b8741b6e9e1b7b94496eeed1b67 |
| ECHA | LOAEC | =15.5964 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID:15828615:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_74196221bbd01af25b8bdd6e34ccbef5 |
| ECHA | LOAEC | =49.1225 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828689_15828690_15829554_15829555:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8829066779c5dda51ef5a76acc16732b |
| ECHA | LOAEL | =74 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bdd46; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/9/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15822151:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_24faaee7970a63453c2d24586e5a09a2 |
| ECHA | LOEC | =0.614032 | mg/m3 | Rat | inhalation | short-term; 10 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID:15828947:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_caab089529382a8269f90cce0c55fafb |
| ECHA | LOEL | =0.245613 | mg/m3 | Mouse | inhalation | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217e98; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/10/2?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=immune system; STUDY_GROUP=ECHA IUCLID:15825486:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_57082a0e272ecb3f3b1d45e1d14c3618 |
| ECHA | LOEL | =0.122806 | mg/m3 | Rat | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d218530; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/10/1?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15825626:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0bdd16c1b5e72160114f2e584a2b0eac |
| ECHA | LOEL | =0.859644 | mg/m3 | Rat | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d218532; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/10/1?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=clinical biochemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECHA IUCLID:15825759:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2113a165d159614369d38059ccee2061 |
| ECHA | NOAEC | =2.45613 | mg/m3 | Mouse | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e0c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816514_15816515_15816516:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50092b8f8b8c19bfca73b4212fe807b4 |
| ECHA | NOAEC | =18.4209 | mg/m3 | Mouse | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e0c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816514_15816515_15816516:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f2cad7a774224ac2acb254c092ee6a7 |
| ECHA | NOAEC | =7.36838 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e18; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816848_15816849_15816850:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5a5bc9e2f8d693b6f190a1fbc777374a |
| ECHA | NOAEC | =0.368419 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e1a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817368_15817369_15817370_15817371_15817944_15817945_15817946_15817947_15819180_15819181:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_42eb762d6ed62605dc87a39c60f67fee |
| ECHA | NOAEC | =1.22806 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e26; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816202_15816203_15817929_15817930:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5406bd2f122120f90e1a75056a0d4fe2 |
| ECHA | NOAEC | =12.2806 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1dbe4b0a7c65d2307a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/9/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15821538:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bc0bec47de699ab40a26a456dc4e2d0d |
| ECHA | NOAEC | =6.14032 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1dbe4b0a7c65d2307a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/9/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15822841:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_edee6f14debce4aa882547af6bb60bcf |
| ECHA | NOAEC | =15.5964 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828689_15828690_15829554_15829555:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_103068c7dab8ddf7f01b96a3ee1e1208 |
| ECHA | NOAEC | =0.859644 | mg/m3 | Rat | inhalation | short-term; 3 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15829131:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_feecd556a5567f8968dab08ca41f5efa |
| ECHA | NOAEC | =3.68419 | mg/m3 | Hamster | inhalation | chronic; 26 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829225_15829226:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa2375ad114604e234139f850423123d |
| ECHA | NOAEC | =4.91225 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828689_15828690_15829554_15829555:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d4573c7dbc27bdc24f66b181cffe6ab2 |
| ECHA | NOAEL | =82 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e16; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816571_15816573_15816575:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aaba1ac010e059f9550b2fb0ccfde6f6 |
| ECHA | NOAEL | =109 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e16; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816572_15816574_15816576:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8d2eaeb05823ed7def06da6d2170079b |
| ECHA | NOAEL | =21 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e16; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816572_15816574_15816576:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b61ea5ccda784aef41a9adc66a19f83a |
| ECHA | NOAEL | <9.21047 | mg/m3 | Mouse | inhalation | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/8?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15819794:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6af1d5ad55915609b237c3310e18498 |
| ECHA | NOAEL | =185 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bdd46; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/9/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15820808:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_332735ca3a0517450cf5c9bb0a97236c |
| ECHA | NOAEL | =25 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4ee4b0a7c65d1c88ec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/2?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=stomach: body weight and weight gain|food consumption and compound intake|gross pathology|haematology|organ weights and organ / body weight ratios|urinalysis|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|hematology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832676_15839607:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8615acf9dc32325dabbe6a9bf69ededa |
| ECHA | NOAEL | <50 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4ee4b0a7c65d1c88f2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/2?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=food consumption and compound intake|food efficiency; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|other; STUDY_GROUP=ECHA IUCLID:15834455:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37463262762b4e6709707a5799188ca7 |
| ECHA | NOAEL | =10 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb42e4b0a7c65d2256bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/2?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=stomach: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832676_15839607:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_86f962750b0b89406049cf4f4936dfa4 |
| ECHA | NOAEL | <20 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4ee4b0a7c65d1c8906; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/2?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|immunology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|organ weight|other; STUDY_GROUP=ECHA IUCLID:15841997:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ff1346f1d37ace7941403ba6df567771 |
| ECHA | NOEC | =2.45613 | mg/m3 | Rat | inhalation | short-term; 4 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23039/7/6/3?documentUUID=7d2fc287-88f7-49b3-87a2-258c60a3d6ca; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827235_15827236:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b6dded4bddeaa85c6ff8521e907fa956 |
EFSA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =15 | mg/kg bw/day | Rat | oral: drinking water | 728 days | chronic/long term toxicity | EFSA AFC - 2007 - OutputID 303 - histopathology non neoplastic - systemic - Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Use of formaldehyde as a preservative during the manufacture and preparation of food additives - doi:10.2903/j.efsa.2007.415 |
| EFSA | NOEL | =15 | mg/kg bw/day | Rat | - | 730 days | chronic/long term toxicity | EFSA CEF - 2010 - OutputID 2042 - Scientific Opinion on Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) - doi:10.2903/j.efsa.2010.1337 |
| EFSA | LEL | =990 | mg/kg bw/day | Chicken | oral | short-term; 28 days | short-term | LONG_REF=EFSA FEEDAP (2004). Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the Commission on safety of formaldehyde for poultry as feed additive in accordance with Council Directive 70/524/EEC. doi:10.2903/j.efsa.2004.96.; TITLE=Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on a request from the Commission on safety of formaldehyde for poultry as feed additive in accordance with Council Directive 70/524/EEC; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2004.96; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614164:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31b0ec14e09c39428ab96ce176f2048e |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 1 | IARC group | - | - | 2009 | IARC Monographs | - |
WHO/JECFA 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =15 | ppm | Rat; Mouse | - | 3 days | Toxicology study | document_id=cicads_cicads_cicad40; title=Formaldehyde (CICADS 40, 2002); path=mirror/documents/cicads/cicads/cicad40.htm; row_hash=735770155819ac31; raw_unit=ppm; context=Effect levels (mg/m 3 ) Protocol NO(A)EL LO(A)EL Critical effect [comments] Reference Short-term toxicity F344 rats and B6C3F1 mice exposed to 0, 0.5, 2, 6, or 15 ppm (0, 0.6, 2.4, 7.2, or 18 mg/m 3 ) formaldehyde for 6 h/day for 3 days. |
| WHO/JECFA | LOAEL | =125 | mg/kg bw/day | Rat | oral | 4 weeks | Toxicology study | document_id=cicads_cicads_cicad40; title=Formaldehyde (CICADS 40, 2002); path=mirror/documents/cicads/cicads/cicad40.htm; row_hash=5cd36f149159aa11; raw_unit=mg/kg body weight per day; context=Protocol Effect levels (mg/kg body weight per day) Critical effect [comments] Reference NOEL LO(A)EL Groups of 10 male and female Wistar rats administered drinking-water containing amounts of formaldehyde estimated sufficient to provide target intakes of 0, 5, 25, or 125 mg/kg body weight per day for 4 weeks. |
| WHO/JECFA | NOAEL | =0.9 | mg/L | - | oral | - | Toxicology study | document_id=cicads_cicads_cicad40; title=Formaldehyde (CICADS 40, 2002); path=mirror/documents/cicads/cicads/cicad40.htm; row_hash=035f937b4d70c841; raw_unit=ug/litre; unit_normalization=converted from micrograms; context=A drinking-water guideline for formaldehyde of 900 ug/litre has been derived based on a no-observed-adverse-effect level (NOAEL) of 15 mg/kg body weight divided by an uncertainty factor of 100, and assuming 20% intake from water (IPCS, 1996). |
| WHO/JECFA | NOEL | =260 | mg/L | Rat | oral | 2 years | Chronic toxicity | document_id=cicads_cicads_cicad40; title=Formaldehyde (CICADS 40, 2002); path=mirror/documents/cicads/cicads/cicad40.htm; row_hash=414a4327931b58d6; raw_unit=mg/litre; context=260 mg/litre is the NOEL for effects (i.e., histopathological changes) in the aerodigestive tract, including oral and gastrointestinal mucosa, of rats administered formaldehyde in drinking-water for 2 years in the most comprehensive study conducted (Til et al., 1989), and 100 is the |
| WHO/JECFA | LOAEL | =0.25 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2003_11; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 132. Formaldehyde; path=mirror/documents/kemi/kemi/ah2003_11.pdf; row_hash=89a12ed1c9b870d9; raw_unit=ppm; context=8.3 Scientific basis for an occupational exposure limit The critical effect of formaldehyde is sensory irritation (LOAEL 0.25 ppm). |
| WHO/JECFA | LOAEL | =2 | ppm | Rat | - | long-term | Toxicology study | document_id=kemi_kemi_ah2003_11; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 132. Formaldehyde; path=mirror/documents/kemi/kemi/ah2003_11.pdf; row_hash=92fe8810dd527212; raw_unit=ppm; context=However, in one long-term study in rats 2.4 mg/m3 (2 ppm) appeared to be a LOAEL (62) and in another long-term rat study a LOAEL as low as 0.36 mg/m3 (0.3 ppm) was reported (60). |
| WHO/JECFA | NOAEL | =1.2 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2003_11; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 132. Formaldehyde; path=mirror/documents/kemi/kemi/ah2003_11.pdf; row_hash=a521efa455dece04; raw_unit=mg/m3; context=Table 4 also reveals that in all studies with a NOAEL of 1.2 mg/m3 (1 ppm) the lowest observed adverse effect level (LOAEL) is higher than 2.4 mg/m3 (2 ppm), indicating a steep dose-response relation (it is possible that in these studies a NOAEL of 2.4 mg/m3 might have been obtained if this exposure concentration would have |
| WHO/JECFA | NOAEL | range:1-22 | ppm | - | inhalation | long-term | Inhalation toxicity | document_id=kemi_kemi_ah2003_11; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 132. Formaldehyde; path=mirror/documents/kemi/kemi/ah2003_11.pdf; row_hash=e42d073aa356b000; raw_unit=ppm; context=The majority of short- and long-term inhalation animal studies reveal a NOAEL of 1-2 ppm. |
| WHO/JECFA | NOAEL | =2.4 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2003_11; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 132. Formaldehyde; path=mirror/documents/kemi/kemi/ah2003_11.pdf; row_hash=add14f62ca55a52f; raw_unit=mg/m3; context=mg/m3 (1 ppm) the lowest observed adverse effect level (LOAEL) is higher than 2.4 mg/m3 (2 ppm), indicating a steep dose-response relation (it is possible that in these studies a NOAEL of 2.4 mg/m3 might have been obtained if this exposure concentration would have been included in these experiments). |
NTP ICE acute inhalation 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 0.5866 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3841; Record_ID=acute_inhalation_2240; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.5866; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE acute inhalation | LC50 | 1.0064 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3842; Record_ID=acute_inhalation_2238; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.0064; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE acute inhalation | LC50 | 1.0002 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3843; Record_ID=acute_inhalation_1653; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.0002; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE acute inhalation | LC50 | 0.3068 | mg/L | - | Inhalation | Duration=2 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3844; Record_ID=acute_inhalation_1647; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.3068; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE acute inhalation | LC50 | 0.578 | mg/L | - | Inhalation | Duration=2 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3845; Record_ID=acute_inhalation_1645; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.578; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE acute inhalation | LC50 | 0.203 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3846; Record_ID=acute_inhalation_954; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.203; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE acute inhalation | LC50 | <0.5682 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3847; Record_ID=acute_inhalation_2429; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=<; Response=0.5682; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15858/7/3/3/?documentUUID=d1a32765-e92b-4790-99da-6355ab1a22cc; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
NTP ICE acute oral 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =100 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_6708; row=11568; data_type=In Vivo; mixture=Chemical; chemical_name=Formaldehyde; preferred_name=Formaldehyde; dtxsid=DTXSID7020637; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020637; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >7000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_6714; row=11570; data_type=In Vivo; mixture=Chemical; chemical_name=Formaldehyde; preferred_name=Formaldehyde; dtxsid=DTXSID7020637; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020637; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2020 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_6713; row=11571; data_type=In Vivo; mixture=Chemical; chemical_name=Formaldehyde; preferred_name=Formaldehyde; dtxsid=DTXSID7020637; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020637; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =800 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_6712; row=11572; data_type=In Vivo; mixture=Chemical; chemical_name=Formaldehyde; preferred_name=Formaldehyde; dtxsid=DTXSID7020637; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020637; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =550 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_6710; row=11574; data_type=In Vivo; mixture=Chemical; chemical_name=Formaldehyde; preferred_name=Formaldehyde; dtxsid=DTXSID7020637; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020637; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_6709; row=11575; data_type=In Vivo; mixture=Chemical; chemical_name=Formaldehyde; preferred_name=Formaldehyde; dtxsid=DTXSID7020637; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020637; source_file=acute_oral.xlsx |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 1 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=7576; Record_ID=cancer_1703; Data_Type=WOE; Formulation_Name=Formaldehyde; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=1; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/80; http://publications.iarc.fr/106; http://publications.iarc.fr/123; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE cancer | Inhalation risk unit | 0.000013 | ug/m3 | - | Inhalation | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=7573; Record_ID=cancer_1705; Data_Type=WOE; Formulation_Name=Formaldehyde; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=IRIS Carcinogenicity; Endpoint=Inhalation risk unit; Response=1.2999999999999999E-5; Response_Unit=ug/m3; Route=Inhalation; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0419_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
NTP ICE skin irritation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | TER | 6.1 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4491; Record_ID=skin_irritation_invitro_2499; Data_Type=In Vitro; Formulation_ID=MIX823; Formulation_Name=dicyanamine/formaldehyde condensate; Mixture=Mixture; DTXSID=DTXSID7020637; Assay=TER Corrosion; Endpoint=TER; Response=6.1; Response_Unit=kiloohms; Reference=Botham et al. 1992; 20732113; 10.1016/0887-2333(92)90031-l; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin irritation | TER | 12.3 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4492; Record_ID=skin_irritation_invitro_2498; Data_Type=In Vitro; Formulation_ID=MIX823; Formulation_Name=dicyanamine/formaldehyde condensate; Mixture=Mixture; DTXSID=DTXSID7020637; Assay=TER Corrosion; Endpoint=TER; Response=12.3; Response_Unit=kiloohms; Reference=Botham et al. 1992; 20732113; 10.1016/0887-2333(92)90031-l; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin irritation | TER | 6.4 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4493; Record_ID=skin_irritation_invitro_2497; Data_Type=In Vitro; Formulation_ID=MIX823; Formulation_Name=dicyanamine/formaldehyde condensate; Mixture=Mixture; DTXSID=DTXSID7020637; Assay=TER Corrosion; Endpoint=TER; Response=6.4; Response_Unit=kiloohms; Reference=Botham et al. 1992; 20732113; 10.1016/0887-2333(92)90031-l; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
NTP ICE skin sensitization 104 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 5.2 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1993; Record_ID=skin_sensitization_invitro_501; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=5.2; Reported_Response_Unit=ug/mL; Response=5.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | CD54, EC200 | 5.14 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2697; Record_ID=skin_sensitization_invitro_638; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=5.14; Reported_Response_Unit=ug/mL; Response=5.14; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | CD86, EC120 | 0.634 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; mMUSST | sheet=Data_invitro; excel_row=7792; Record_ID=skin_sensitization_invitro_1890; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=mMUSST; Endpoint=CD86, EC120; Reported_Response=21.1; Reported_Response_Unit=uM; Conversion_Factor_Value=30.026; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.634; Converted_Response_Unit=ug/mL; Response=0.634; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | CD86, EC150 | 4.3 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1991; Record_ID=skin_sensitization_invitro_501; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=4.3; Reported_Response_Unit=ug/mL; Response=4.3; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | CD86, EC150 | 1.6 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8296; Record_ID=skin_sensitization_invitro_2300; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=53.28005328; Reported_Response_Unit=uM; Conversion_Factor_Value=30.026; Conversion_Factor_Source=EPA Dashboard; Converted_Response=1.6; Converted_Response_Unit=ug/mL; Response=1.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | CD86, EC150 | 5.74 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8511; Record_ID=skin_sensitization_invitro_2346; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=5.74; Reported_Response_Unit=ug/mL; Response=5.74; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | CV75 | 5.8 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1995; Record_ID=skin_sensitization_invitro_501; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=h-CLAT; Endpoint=CV75; Reported_Response=5.8; Reported_Response_Unit=ug/mL; Response=5.8; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | CV75 | 23.3 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2688; Record_ID=skin_sensitization_invitro_636; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=h-CLAT; Endpoint=CV75; Reported_Response=23.3; Reported_Response_Unit=ug/mL; Response=23.3; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 0.1285 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7524; Record_ID=skin_sensitization_invivo_1714; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.1285; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Greif 1967; Not available; Not available|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 1.202 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7531; Record_ID=skin_sensitization_invivo_1715; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.202; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 0.4116 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7546; Record_ID=skin_sensitization_invivo_1717; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.37; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.4116; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 2.359 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7547; Record_ID=skin_sensitization_invivo_1718; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.359; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 0.9768 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7562; Record_ID=skin_sensitization_invivo_1719; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.11; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.9768; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.1028 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7522; Record_ID=skin_sensitization_invivo_1714; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.1028; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Greif 1967; Not available; Not available|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.4625 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7527; Record_ID=skin_sensitization_invivo_1715; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.4625; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.0925 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7542; Record_ID=skin_sensitization_invivo_1717; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.37; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.0925; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.222 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7558; Record_ID=skin_sensitization_invivo_1719; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.11; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.222; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 48.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=495; Record_ID=skin_sensitization_invitro_148; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=48.6; Reported_Response_Unit=%; Response=48.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 37.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=501; Record_ID=skin_sensitization_invitro_149; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=37.299999999999997; Reported_Response_Unit=%; Response=37.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 36.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=507; Record_ID=skin_sensitization_invitro_151; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=36.700000000000003; Reported_Response_Unit=%; Response=36.7; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 44.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=519; Record_ID=skin_sensitization_invitro_154; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=44.2; Reported_Response_Unit=%; Response=44.2; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 30.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=523; Record_ID=skin_sensitization_invitro_155; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=30.5; Reported_Response_Unit=%; Response=30.5; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 36.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=527; Record_ID=skin_sensitization_invitro_156; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=36.6; Reported_Response_Unit=%; Response=36.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 40.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=535; Record_ID=skin_sensitization_invitro_158; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=40.6; Reported_Response_Unit=%; Response=40.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 54.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=542; Record_ID=skin_sensitization_invitro_159; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=54.8; Reported_Response_Unit=%; Response=54.8; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 49.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=543; Record_ID=skin_sensitization_invitro_160; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=49.6; Reported_Response_Unit=%; Response=49.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 51.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=550; Record_ID=skin_sensitization_invitro_161; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=51.4; Reported_Response_Unit=%; Response=51.4; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 60.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=551; Record_ID=skin_sensitization_invitro_162; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=60.4; Reported_Response_Unit=%; Response=60.4; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Cys | 44.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=557; Record_ID=skin_sensitization_invitro_146; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=44.7; Reported_Response_Unit=%; Response=44.7; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=493; Record_ID=skin_sensitization_invitro_148; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2; Reported_Response_Unit=%; Response=2; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 1.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=499; Record_ID=skin_sensitization_invitro_149; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.8; Reported_Response_Unit=%; Response=1.8; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 1.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=506; Record_ID=skin_sensitization_invitro_151; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.3; Reported_Response_Unit=%; Response=1.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 3.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=518; Record_ID=skin_sensitization_invitro_154; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=3.6; Reported_Response_Unit=%; Response=3.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 0.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=522; Record_ID=skin_sensitization_invitro_155; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.3; Reported_Response_Unit=%; Response=0.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 3.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=526; Record_ID=skin_sensitization_invitro_156; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=3.2; Reported_Response_Unit=%; Response=3.2; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 3.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=533; Record_ID=skin_sensitization_invitro_158; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=3.8; Reported_Response_Unit=%; Response=3.8; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 2.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=540; Record_ID=skin_sensitization_invitro_159; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.4; Reported_Response_Unit=%; Response=2.4; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 2.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=541; Record_ID=skin_sensitization_invitro_160; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.2999999999999998; Reported_Response_Unit=%; Response=2.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 2.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=548; Record_ID=skin_sensitization_invitro_161; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.5; Reported_Response_Unit=%; Response=2.5; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 11.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=549; Record_ID=skin_sensitization_invitro_162; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=11.2; Reported_Response_Unit=%; Response=11.2; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys | 4.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=556; Record_ID=skin_sensitization_invitro_146; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=4.2; Reported_Response_Unit=%; Response=4.2; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 25.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=496; Record_ID=skin_sensitization_invitro_148; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=25.3; Reported_Response_Unit=%; Response=25.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 19.55 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=502; Record_ID=skin_sensitization_invitro_149; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=19.55; Reported_Response_Unit=%; Response=19.55; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 19 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=508; Record_ID=skin_sensitization_invitro_151; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=19; Reported_Response_Unit=%; Response=19; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 24 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=520; Record_ID=skin_sensitization_invitro_154; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=24; Reported_Response_Unit=%; Response=24; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 15.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=524; Record_ID=skin_sensitization_invitro_155; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=15.4; Reported_Response_Unit=%; Response=15.4; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 19.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=530; Record_ID=skin_sensitization_invitro_156; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=19.899999999999999; Reported_Response_Unit=%; Response=19.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 22.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=537; Record_ID=skin_sensitization_invitro_158; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=22.2; Reported_Response_Unit=%; Response=22.2; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 25.95 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=544; Record_ID=skin_sensitization_invitro_160; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=25.95; Reported_Response_Unit=%; Response=25.95; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 28.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=545; Record_ID=skin_sensitization_invitro_159; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=28.6; Reported_Response_Unit=%; Response=28.6; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 26.95 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=552; Record_ID=skin_sensitization_invitro_161; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=26.95; Reported_Response_Unit=%; Response=26.95; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 35.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=554; Record_ID=skin_sensitization_invitro_162; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=35.799999999999997; Reported_Response_Unit=%; Response=35.8; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 24.45 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=558; Record_ID=skin_sensitization_invitro_146; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=24.45; Reported_Response_Unit=%; Response=24.45; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC1.5 | 137 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5848; Record_ID=skin_sensitization_invitro_1378; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=137; Reported_Response_Unit=uM; Response=137; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC1.5 | 63.21 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5850; Record_ID=skin_sensitization_invitro_1377; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=63.21; Reported_Response_Unit=uM; Response=63.21; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC1.5 | 184.4 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7608; Record_ID=skin_sensitization_invitro_1847; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LuSens; Endpoint=EC1.5; Reported_Response=184.3783982; Reported_Response_Unit=uM; Response=184.4; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 72.2 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5852; Record_ID=skin_sensitization_invitro_1377; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=72.200999999999993; Reported_Response_Unit=uM; Response=72.2; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 0.7 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12805; Record_ID=skin_sensitization_invivo_2808; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=0.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 0.61 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13244; Record_ID=skin_sensitization_invivo_3317; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=0.61; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1998; 9471984; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 0.37 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13246; Record_ID=skin_sensitization_invivo_3319; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=0.37; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 0.99 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13247; Record_ID=skin_sensitization_invivo_3322; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=0.99; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 0.35 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13248; Record_ID=skin_sensitization_invivo_3323; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=0.35; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 2001; 11553118; 10.1034/j.1600-0536.2001.045002089.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 0.44 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13249; Record_ID=skin_sensitization_invivo_3324; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=0.44; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 2003; Not available; 10.1081/CUS-120026299; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 0.27 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13251; Record_ID=skin_sensitization_invivo_3326; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=0.27; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Ryan et al. 2002; 12176099; 10.1016/s0278-6915(02)00116-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 0.11 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13252; Record_ID=skin_sensitization_invivo_3327; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=0.11; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1996; 8690318; 10.1016/0278-6915(96)00012-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 0.3 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13253; Record_ID=skin_sensitization_invivo_3328; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=0.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Ryan et al. 2002; 12176099; 10.1016/s0278-6915(02)00116-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 14.5 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13254; Record_ID=skin_sensitization_invivo_3330; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=14.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Ryan et al. 2002; 12176099; 10.1016/s0278-6915(02)00116-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 3.6 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13255; Record_ID=skin_sensitization_invivo_3332; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=3.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 2003; Not available; 10.1081/CUS-120026299; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 4.2 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13257; Record_ID=skin_sensitization_invivo_3334; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=4.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Ryan et al. 2002; 12176099; 10.1016/s0278-6915(02)00116-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 3.8 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13259; Record_ID=skin_sensitization_invivo_3337; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=3.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ECPA personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 8 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13261; Record_ID=skin_sensitization_invivo_3339; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ECPA personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 5.6 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13262; Record_ID=skin_sensitization_invivo_3340; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=5.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ECPA personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 8.2 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13264; Record_ID=skin_sensitization_invivo_3343; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=8.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ECPA personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | EC3 | 12.3 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13265; Record_ID=skin_sensitization_invivo_3346; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LLNA; Endpoint=EC3; Response=12.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ECPA personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | IC50 | 201.63 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5854; Record_ID=skin_sensitization_invitro_1377; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=201.63; Reported_Response_Unit=uM; Response=201.63; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | IC50 | 385.9 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5856; Record_ID=skin_sensitization_invitro_1378; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=385.9; Reported_Response_Unit=uM; Response=385.9; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | IC50 | >288 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7677; Record_ID=skin_sensitization_invitro_1847; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=288; Reported_Response_Unit=uM; Response=288; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Imax | 16.92 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5858; Record_ID=skin_sensitization_invitro_1377; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=16.920000000000002; Reported_Response_Unit=Unitless; Response=16.92; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Imax | 4.1 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5860; Record_ID=skin_sensitization_invitro_1378; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=4.0999999999999996; Reported_Response_Unit=Unitless; Response=4.1; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Imax | 3.99 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7581; Record_ID=skin_sensitization_invitro_1847; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=LuSens; Endpoint=Imax; Reported_Response=3.989754477; Reported_Response_Unit=Unitless; Response=3.99; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Incidence of positive responses | 72 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7520; Record_ID=skin_sensitization_invivo_1714; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=72; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Greif 1967; Not available; Not available|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7530; Record_ID=skin_sensitization_invivo_1716; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.037; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Incidence of positive responses | 4.494 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7538; Record_ID=skin_sensitization_invivo_1717; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.37; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=4.494; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Incidence of positive responses | 7.843 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7539; Record_ID=skin_sensitization_invivo_1718; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=7.843; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Incidence of positive responses | 5.682 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7554; Record_ID=skin_sensitization_invivo_1719; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.11; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=5.682; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Incidence of positive responses | 7.692 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7570; Record_ID=skin_sensitization_invivo_1715; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=7.692; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area | 1148 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7518; Record_ID=skin_sensitization_invivo_1714; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1148; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Greif 1967; Not available; Not available|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area | 28.68 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7528; Record_ID=skin_sensitization_invivo_1716; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.037; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=28.68; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area | 286.8 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7536; Record_ID=skin_sensitization_invivo_1717; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.37; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=286.8; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area | 2868 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7537; Record_ID=skin_sensitization_invivo_1718; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=2868; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area | 860.3 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7552; Record_ID=skin_sensitization_invivo_1719; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.11; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=860.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area | 1434 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7568; Record_ID=skin_sensitization_invivo_1715; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1434; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 79.74 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7525; Record_ID=skin_sensitization_invivo_1714; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=79.74; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Greif 1967; Not available; Not available|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 931.9 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7533; Record_ID=skin_sensitization_invivo_1715; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=931.9; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 319 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7548; Record_ID=skin_sensitization_invivo_1717; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.37; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=319; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 1828 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7549; Record_ID=skin_sensitization_invivo_1718; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1828; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 757 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7564; Record_ID=skin_sensitization_invivo_1719; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.11; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=757; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 63.79 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7523; Record_ID=skin_sensitization_invivo_1714; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=63.79; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Greif 1967; Not available; Not available|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 358.4 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7529; Record_ID=skin_sensitization_invivo_1715; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=358.4; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 71.69 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7544; Record_ID=skin_sensitization_invivo_1717; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.37; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=71.69; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 172.1 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7560; Record_ID=skin_sensitization_invivo_1719; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.11; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=172.1; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7526; Record_ID=skin_sensitization_invivo_1714; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Greif 1967; Not available; Not available|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7534; Record_ID=skin_sensitization_invivo_1716; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.037; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7535; Record_ID=skin_sensitization_invivo_1715; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.85; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020637; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020637; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020637 |
SCCS Opinion 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.08 | ppm | - | - | - | irritation | p.12 |
| SCCS Opinion | NOAEL | =0.3 | ppm | rat | oral | - | genotoxicity | p.10 |
| SCCS Opinion | NOAEL | =0.4 | ppm | rat | - | developmental | reproductive toxicity | p.61 |
| SCCS Opinion | NOAEL | =0.5 | ppm | rat | oral | - | repeated dose toxicity | p.10 |
| SCCS Opinion | NOAEL | =1 | ppm | rat | inhalation | 13 weeks | irritation | p.36 |
| SCCS Opinion | NOAEL | =1 | % | rat | inhalation | 60 weeks | NOAEL study | p.38 |
| SCCS Opinion | NOAEL | =2 | ppm | rat | inhalation | 1 day | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =4 | ppm | mouse | oral | Chronic | carcinogenicity | p.37 |
| SCCS Opinion | NOAEL | =5 | ppm | rat | inhalation | - | developmental toxicity | p.61 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/day | rat | oral | - | repeated dose toxicity | p.10 |
| SCCS Opinion | NOAEL | =10 | ppm | rat | inhalation | - | carcinogenicity | p.39 |
| SCCS Opinion | NOAEL | =15 | mg/kg bw/day | rat | oral | - | carcinogenicity | p.11 |
| SCCS Opinion | NOAEL | =21 | mg/kg bw/day | rat | oral | chronic | carcinogenicity | p.46 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/day | rat | oral | 28 days | irritation | p.33 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw/day | rat | oral | - | repeated dose toxicity | p.39 |
| SCCS Opinion | NOAEL | =2012 | - | - | - | - | irritation | p.12 |
ToxValDB ATSDR MRLs 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =0.491225 | mg/m3 | Human | inhalation | acute; 2 hours | clinical | LONG_REF=Pazdrak, K, Gorski, P, Krakowiak, A and Urszula, R (1993). Changes in Nasal Lavage Fluid Due to Formaldehyde Inhalation. Int Arch Occup Environ Health 64: 515-519.; TITLE=Changes in Nasal Lavage Fluid Due to Formaldehyde Inhalation; AUTHOR=Pazdrak, K; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp111.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447614:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cf1fbad1107b9e6129b2b99265cec7a0 |
| ToxValDB ATSDR MRLs | LOAEL | =0.294735 | mg/m3 | Human | inhalation | chronic; 1 years | occupational | LONG_REF=Holmstrom M, Wilhelmsson B, Hellquist H, et al. 1989c. Histological changes in the nasal mucosa in persons occupationally exposed to formaldehyde alone and in combination with wood dust. Acta Otolaryngol (Stockh) 107:120-129.; TITLE=Histological changes in the nasal mucosa in persons occupationally exposed to formaldehyde alone and in combination with wood dust; AUTHOR=Holmstrom M; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp111.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447616:unknown:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_841fde9e4b22207961a471ca954b8195 |
| ToxValDB ATSDR MRLs | MRL | =0.0491225 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15447082_15447083_15447084:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89141b522e30730324a216f42e22f17f |
| ToxValDB ATSDR MRLs | MRL | =0.0368419 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=respiratory in male monkeys; STUDY_GROUP=ATSDR MRLs_dup_-_15447082_15447083_15447084:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26f94965b523a5a12e389150600eb9cc |
| ToxValDB ATSDR MRLs | MRL | =0.00982451 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15447082_15447083_15447084:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_981d4a6391523c8fc2654c80bf523bdd |
| ToxValDB ATSDR MRLs | MRL | =0.3 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=gastrointestinal in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447085_15447086:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bee33c9e35f442cbb39f1e5c47ca6b49 |
| ToxValDB ATSDR MRLs | MRL | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=gastrointestinal in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447085_15447086:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0cec744cd9d1dfc23a489dc85ace52b |
| ToxValDB ATSDR MRLs | NOAEL | =1.2035 | mg/m3 | Monkey | inhalation | chronic; 26 weeks | chronic | LONG_REF=Rusch, G, Clary, JJ, Rinehart WE and Bolte, HF (1983). A 26 Week Inhalation Toxicity Study with Formaldehyde in the Monkey, Rat and Hamster. Toxicol Appl Pharmacol 68: 329-343.; TITLE=A 26 Week Inhalation Toxicity Study with Formaldehyde in the Monkey, Rat and Hamster; AUTHOR=Rusch, G; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp111.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447615:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b7d7b46c4a865558144112b38efa6ac1 |
| ToxValDB ATSDR MRLs | NOAEL | =25 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | LONG_REF=Til HP, Woutersen RA, Feron VJ, Clary JJ (1988b). Evaluation of the oral toxicity of acetaldehyde and formaldehyde in a 4-week drinking-water study in rats. Fd. Chem. Toxic 26: 447-452.; TITLE=Evaluation of the oral toxicity of acetaldehyde and formaldehyde in a 4-week drinking-water study in rats; AUTHOR=Til HP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp111.pdf; TOXICOLOGICAL_EFFECT=gastrointestinal; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447617:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_50039a1b2b335c71d69bf7afa34958dd |
| ToxValDB ATSDR MRLs | NOAEL | =15 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=Til HP, Woutersen RA, Feron VJ, Hollanders VHM, Falke HE, Clary JJ (1989). Two-year drinking-water study of formaldehyde in rats. Fd. Chem. Toxic 27: 77-86.; TITLE=Two-year drinking-water study of formaldehyde in rats; AUTHOR=Til HP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585770; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp111.pdf; TOXICOLOGICAL_EFFECT=gastrointestinal; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447618:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_35d04e01cc2a7478f85cff5cd4c4dcf4 |
ToxValDB Cal OEHHA REL derivations 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | BMCL (05) | =0.540348 | mg/m3 | Human | inhalation | acute; 3 hours | clinical | LONG_REF=Kulle TJ, Sauder LR, Hebel JR, Green DJ and Chatham MD (1987). Formaldehyde dose-response in healthy nonsmokers. Japca 37(8): 919-24.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd1final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=mild and moderate eye irritation; STUDY_GROUP=Cal OEHHA REL derivations_dup_-_15951882_15951883:-:-nonasthmatic, nonsmoking; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6c7a35bbbda621f86c5e13726c8f7699 |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =0.614032 | mg/m3 | Human | inhalation | acute; 3 hours | clinical | LONG_REF=Kulle TJ, Sauder LR, Hebel JR, Green DJ and Chatham MD (1987). Formaldehyde dose-response in healthy nonsmokers. Japca 37(8): 919-24.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd1final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=mild and moderate eye irritation; STUDY_GROUP=Cal OEHHA REL derivations_dup_-_15951882_15951883:-:-nonasthmatic, nonsmoking; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7fdfb396e5f3a076e6816abc7e188fbf |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =0.09 | mg/m3 | Human | inhalation | chronic; 10 years | occupational | LONG_REF=Wilhelmsson and Holmstrom, 1992; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd1final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Nasal obstruction and discomfort, lower airway discomfort, and eye irritation.; STUDY_GROUP=Cal OEHHA REL derivations:15951885:-:-adult chemical plant workers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4b259bb3933bf7825377a13857c0ed5c |
ToxValDB DOE Wildlife Benchmarks 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =9.4 | mg/kg bw/day | Dog | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks:15511634:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02f8fded7a1da607cc1c7d0e33c9d5e8 |
ToxValDB ECOTOX 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =0.006 | mg/mL | Rat | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599395_15599396_15599397_15599399:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8e9660defa19d3e4c1e8f213c1653090 |
| ToxValDB ECOTOX | LOEL | =0.003 | mg/mL | Rat | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Development: Normal|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599394_15599398_15599400:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=db521d36a409825d9da7807acdbb2a76 |
| ToxValDB ECOTOX | LOEL | =30 | % w/v | Mouse | dermal | short-term; 3 days | short-term | LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601842_15601843_15601844_15601845:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f2e3bfafea2b550e7902fba1ea1f820c |
| ToxValDB ECOTOX | LOEL | =0.004 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607286_15607289_15607290:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b1aa204cd0ff8d5da40a11e07c8daa61 |
| ToxValDB ECOTOX | LOEL | =0.001 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607286_15607289_15607290:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=837a12c39b7bbe2bfb8b0e9792934c53 |
| ToxValDB ECOTOX | LOEL | =5 | % | Mouse | dermal | short-term; 16 days | short-term | LONG_REF=Contact Dermatitis15(1): 17-23 Maisey,J., and K. Miller Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers 1986; TITLE=Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers; AUTHOR=Maisey,J., and K. Miller; DOI=10.1111/j.1600-0536.1986.tb01255.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Immunological: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15608373:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5fe845f863a34899fe9f1a2a45bebab4 |
| ToxValDB ECOTOX | LOEL | =0.000003 | mg | Mouse | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Development: Normal|Genetics: DNA concentration|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|other; STUDY_GROUP=ECOTOX:15610905:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=58c44e892c795b9d2c575e5102c8e300 |
| ToxValDB ECOTOX | LOEL | =0.00101 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610906_15610907_15610908_15610909:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b39ad9123a5aa0a21bb5a4d6c57c9831 |
| ToxValDB ECOTOX | LOEL | =0.00151 | mg | Rat | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610968_15610972:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c3083169da9c0aa2b1ceac91076c1eb0 |
| ToxValDB ECOTOX | NOEL | =0.006 | mg/mL | Rat | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Development: Organ/tissue formation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599394_15599398_15599400:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4beb10e8fc018531f709b3158b86706c |
| ToxValDB ECOTOX | NOEL | =0.004 | mg/mL | Rat | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599395_15599396_15599397_15599399:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f9e004c7969d494b19dd6d77bd7e7ffb |
| ToxValDB ECOTOX | NOEL | =0.003 | mg/mL | Rat | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599395_15599396_15599397_15599399:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5cc3477425e47e93993d0b7c25febca6 |
| ToxValDB ECOTOX | NOEL | =0.001 | mg/mL | Rat | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Development: Normal|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599394_15599398_15599400:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7bc7d36072605b797898c802ca43d3a3 |
| ToxValDB ECOTOX | NOEL | =15 | % w/v | Mouse | dermal | short-term; 3 days | short-term | LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601842_15601843_15601844_15601845:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3ea542c5b00699a304f158eb034e37d2 |
| ToxValDB ECOTOX | NOEL | =7.5 | % w/v | Mouse | dermal | short-term; 3 days | short-term | LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601842_15601843_15601844_15601845:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=056d13c336e7d9d03e2febaa318892e4 |
| ToxValDB ECOTOX | NOEL | =0.05 | % org | European Rabbit | injection | acute; 0.0556 days | acute | LONG_REF=J. Evol. Biochem. Physiol.37(6): 634-641 Kassil,V.G., I.P. Butkevich, and V.A. Mikhailenko Interaction of Tonic and Phasic Pain in Rabbit Ontogenesis 2001; TITLE=Interaction of Tonic and Phasic Pain in Rabbit Ontogenesis; AUTHOR=Kassil,V.G., I.P. Butkevich, and V.A. Mikhailenko; DOI=10.1023/A:1014474412031; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=189765; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Behavior: Flight|Physiology: Electrophysiological response|Physiology: Energy charge potential; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602880_15602881:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=49ab0c1fe088d6d5c1b92bff8cc68026 |
| ToxValDB ECOTOX | NOEL | =0.000501 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610906_15610907_15610908_15610909:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0757006ac506edba29a95d6b3ef0f722 |
| ToxValDB ECOTOX | NOEL | =0.000003 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610906_15610907_15610908_15610909:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c7d429bc55299aec8ed7cebf59c4dc8a |
| ToxValDB ECOTOX | NOEL | =0.00151 | mg | Rat | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Organ/tissue formation|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=development|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610969_15610970_15610971:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e32e0d4c8395ab6f9ca3e1b2ee23021c |
| ToxValDB ECOTOX | NOEL | =0.00101 | mg | Rat | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610968_15610972:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=360075f8fec2d0879ac26e13c1db094b |
ToxValDB EPA TSCA 8e 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | >20 | mg/L | Rat | inhalation | acute; 7 hours | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=2010-12-8EHQ-10-18217A_8ehq_1210_18217a.pdf; TOXICOLOGICAL_EFFECT=mortality, escape behavior, watery eyes, nasal secretion, dyspnea, staggered gait, and ruffled fur, but the exposure duration was not specified, dilation of the heart, hyperemia, lung edema; STUDY_GROUP=EPA TSCA 8e_dup_-_15957186_15957187_15957189:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_41c4d59562c5b9c519cd7028a8e12597 |
| ToxValDB EPA TSCA 8e | LEL | <21 | mg/L | Rat | inhalation | acute; 7 hours | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=2010-12-8EHQ-10-18217A_8ehq_1210_18217a.pdf; TOXICOLOGICAL_EFFECT=mortality, escape behavior, watery eyes, nasal secretion, dyspnea, staggered gait, and ruffled fur, but the exposure duration was not specified, dilation of the heart, hyperemia, lung edema; STUDY_GROUP=EPA TSCA 8e_dup_-_15957186_15957187_15957189:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cbdfebdc5c0546c4cab9e1909c187cfb |
| ToxValDB EPA TSCA 8e | LEL | =17 | mg/L | Rat | inhalation | acute; 7 hours | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=2010-12-8EHQ-10-18217A_8ehq_1210_18217a.pdf; TOXICOLOGICAL_EFFECT=mortality, watery and reddened nasal secretion, watery eyes, dyspnea, wheeze and tremor, staggering gail, ruffled fur, reddened nose with eschar formation, dilation of heart, hyperemia, lung edema; STUDY_GROUP=EPA TSCA 8e_dup_-_15957186_15957187_15957189:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ebc77709cb8b79eda478c9411246329d |
| ToxValDB EPA TSCA 8e | LEL | =12.2806 | mg/m3 | Rat | inhalation | short-term (developmental); 10 days | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010941_50000_4829E435803F4FBB85256930004F2801.pdf; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=P0: decreased body weight, decreased body weight gain, reduced food consumption; STUDY_GROUP=EPA TSCA 8e:15957190:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_374616b3c83ce7b89ad6eec565cd8f5e |
| ToxValDB EPA TSCA 8e | LEL | =1.28 | ppm | Human | oral | - | clinical | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=2009-11-8EHQ-09-17729A_8ehq_1109_17729a.pdf; TOXICOLOGICAL_EFFECT=reduced total white blood cell counts, lower levels of granulocytes, platelets, red blood cell counts, lymphocyte counts, increased leukemia-specific chromosomal aneuploidy in hematopoietic progenitor cells; STUDY_GROUP=EPA TSCA 8e:15957191:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_75e786a503accb738b813ccaefae56c1 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.375 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632317_15632318:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c921fa5ec871f6e41ec6e4e0559433d |
| ToxValDB GESTIS DNEL | DNEL systemic | =9 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632317_15632318:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50209cad3a75151a271ba03347211d73 |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfC | =0.009 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650132:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fb9833636935eec4d6dbd94a96f3ca8 |
ToxValDB RSL 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfC | =0.0098 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_ATSDR_15656489_15663461_15663463:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee53d47def7c03a83a306c8efa6d4a5f |
| ToxValDB RSL | RfC | =0.00982577 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_ATSDR_15656489_15663461_15663463:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9692f7e44284cab966a771878b155c6a |
| ToxValDB RSL | RfC | =0.0368466 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_ATSDR_15656489_15663461_15663463:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_103291bef604a5b56daac5862a202a53 |
ToxValDB TX TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | LOAEL | =0.5 | mg/m3 | Human | inhalation | acute; 2 hours | clinical | LONG_REF=Pazdrak K, Gorski P, Krakowiak A, et al. 1993. Changes in nasal lavage fluid due to formaldehyde inhalation. Int Arch Occup Environ Health 64:515-519. Krakowiak A, Gorski P, Pazdrak K, et al. 1998. Airway response to formaldehyde inhalation in asthmatic subjects with suspected respiratory formaldehyde sensitization. Am J Ind Med 33:274-281; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b01; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/formaldehyde.pdf; YEAR=August 7, 2008; Accessible 2013 24-Hour Reference Value: September 14, 2015; ORIGINAL_YEAR=August 7, 2008; Accessible 2013 24-Hour Reference Value: September 14, 2015; TOXICOLOGICAL_EFFECT=Eye and nose irritation, symptoms of rhinitis; STUDY_GROUP=TX TCEQ:15954459:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f33bb81dbd6351d8c662a4c01319c282 |
openFDA substances 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 1HG84L3525 | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | T0H3L6C7I5 | UNII | - | - | - | specifiedSubstanceG1 | - |