NOAEL Studies
Cosmetic Ingredient
Formic Acid NOAEL Studies
INCI: FORMIC ACID
CAS: 64-18-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =945 | mg/kg body weight | rabbit | oral | 21 weeks | developmental toxicity | 945; 22; (13, p.9 |
| CIR Safety Assessment | NOAEL | =1000 | mg/kg body weight/day | rat | - | - | reproductive toxicity | 13; 0; 9, p.9 |
COSMOS DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 42 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | ADI (group) | =0.3 | mg/kg bw | Consumers | - | - | ADI (group) | EFSA CONTAM - 2012 - OutputID 602 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III - doi:10.2903/j.efsa.2012.2703 |
WHO/JECFA 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | range:0-0.10.1 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v040je10; title=906. Saturated aliphatic acyclic linear primary alcohols, aldehydes and acids (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je10.htm; row_hash=5d4387b65b9adceb; raw_unit=mg/kg bw; context=A group ADI of 0-0.1 mg/kg bw was established for ocatanal and nonanal, singly or in combination, at the twenty-eighth meeting (Annex 1, reference 66). |
| WHO/JECFA | ADI | range:0-33 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v040je10; title=906. Saturated aliphatic acyclic linear primary alcohols, aldehydes and acids (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je10.htm; row_hash=8d756f164b09ae0e; raw_unit=mg/kg bw; context=he seventeenth meeting a group ADI "not limited" was allocated to acetic acid and its potassium and sodium salts, an ADI "not limited" was allocated to propionic acid, and a group ADI of 0-3 mg/kg bw was allocated to formic acid and ethyl formate (Annex 1, reference 32). |
| WHO/JECFA | NOAEL | =577 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v040je10; title=906. Saturated aliphatic acyclic linear primary alcohols, aldehydes and acids (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je10.htm; row_hash=f3120ff6c5fbba73; raw_unit=mg/kg bw per day; context=A NOAEL of 1% (equal to 577 mg/kg bw per day) was determined from this study (Eibert, 1992). |
| WHO/JECFA | NOAEL | range:230-695695 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v040je10; title=906. Saturated aliphatic acyclic linear primary alcohols, aldehydes and acids (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je10.htm; row_hash=0aa653addd8a623a; raw_unit=mg/kg bw; context=A NOAEL of 1%, which corresponds to a daily intake of 230-695 mg/kg bw, was determined from this study (Eibert, 1992). |
| WHO/JECFA | NOAEL | =807 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v040je10; title=906. Saturated aliphatic acyclic linear primary alcohols, aldehydes and acids (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je10.htm; row_hash=8329dbb2e5f588ef; raw_unit=mg/kg bw per day; context=A NOAEL of 3% (equal to 807 mg/kg bw per day) was determined from this study (Eibert, 1992). |
| WHO/JECFA | NOEL | =50 | mg/kg bw/day | Rabbit | oral | 6 months | Toxicology study | document_id=jecfa_jecmono_v040je10; title=906. Saturated aliphatic acyclic linear primary alcohols, aldehydes and acids (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je10.htm; row_hash=aeb903e99331b8fb; raw_unit=mg/kg bw per day; context=The NOEL in rabbits given 0, 1.4, 14 or 50 mg/kg bw per day heptyl alcohol by gavage in sunflower oil for 6 months was 50 mg/kg bw per day (Voskoboinikova, 1966). |
| WHO/JECFA | NOEL | =60 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v040je10; title=906. Saturated aliphatic acyclic linear primary alcohols, aldehydes and acids (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je10.htm; row_hash=6ec17c3894598585; raw_unit=mg/kg bw per day; context=A NOEL of 60 mg/kg bw per day was determined in this study (Hillbom et al ., 1974b). |
| WHO/JECFA | NOEL | =125 | mg/kg bw/day | Rat | oral | 4 weeks | Toxicology study | document_id=jecfa_jecmono_v040je10; title=906. Saturated aliphatic acyclic linear primary alcohols, aldehydes and acids (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je10.htm; row_hash=3e2951d2e8de3604; raw_unit=mg/kg bw per day; context=2.2.2.1 Acetaldehyde A NOEL of 125 mg/kg bw per day was reported for acetaldehyde added to the drinking-water of male and female rats for 4 weeks at level of 0, 25, 125 or 625 mg/kg bw per day (Til et al., 1988); the only treatment-related effect was hyperkeratosis of the forestomach at 625 mg/kg bw per day. |
| WHO/JECFA | ADI | <=3 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afe27e4b0d99f5a87f9c9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1561; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=WHO JECFA ADI:15715522:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa81f81ce94f45e674bf26fe14718c32 |
NTP ICE acute inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 7.4 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1445; Record_ID=acute_inhalation_1693; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.4; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE acute inhalation | LC50 | 7.85 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1446; Record_ID=acute_inhalation_766; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.85; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15127/7/3/3/?documentUUID=38cca90d-e2ec-4d48-b7b4-f7ca82e30097; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE acute inhalation | LC50 | 15 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1444; Record_ID=acute_inhalation_2764; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=15; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =1100 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8831; row=4113; data_type=In Vivo; mixture=Chemical; chemical_name=Formic acid; preferred_name=Formic acid; dtxsid=DTXSID2024115; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2024115; source_file=acute_oral.xlsx |
NTP ICE skin irritation 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Breakthrough Time | 6.5 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=1797; Record_ID=skin_irritation_invitro_96; Data_Type=In Vitro; Concentration=96; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=Corrositex; Endpoint=Breakthrough Time; Response=6.5; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Breakthrough Time | 15.7 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=1789; Record_ID=skin_irritation_invitro_97; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=Corrositex; Endpoint=Breakthrough Time; Response=15.7; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Breakthrough Time | 18.5 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=1794; Record_ID=skin_irritation_invitro_98; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=Corrositex; Endpoint=Breakthrough Time; Response=18.5; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | TER | 1.8 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=1784; Record_ID=skin_irritation_invitro_2555; Data_Type=In Vitro; Concentration=33.9; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=TER Corrosion; Endpoint=TER; Response=1.8; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | TER | 2.7 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=1785; Record_ID=skin_irritation_invitro_2556; Data_Type=In Vitro; Concentration=33.9; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=TER Corrosion; Endpoint=TER; Response=2.7; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Viability (240 minutes) | 5.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=1780; Record_ID=skin_irritation_invitro_2027; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=5.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Viability (240 minutes) | 9.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=1777; Record_ID=skin_irritation_invitro_2025; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=9.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Viability (240 minutes) | 9.9 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=1783; Record_ID=skin_irritation_invitro_2029; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=9.9; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Viability (3 minutes) | 4.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=1782; Record_ID=skin_irritation_invitro_2025; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=4.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Viability (3 minutes) | 5.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=1781; Record_ID=skin_irritation_invitro_2027; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=5.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Viability (3 minutes) | 7.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=1776; Record_ID=skin_irritation_invitro_2029; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=7.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Viability (60 minutes) | 4.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=1778; Record_ID=skin_irritation_invitro_2027; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=4.40; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Viability (60 minutes) | 4.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=1779; Record_ID=skin_irritation_invitro_2029; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=4.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
| NTP ICE skin irritation | Viability (60 minutes) | 5.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=1788; Record_ID=skin_irritation_invitro_2025; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2024115; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=5.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024115; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024115 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =338836 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=DOE Protective Action Criteria:15515694:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f9eb3484c605d0e0431dad6de8d3eac8 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =9.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632333:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7bcaa6992505e20e99e42f703be5fdba |
ToxValDB HPVIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | LOAEL | =0.12 | mg/L | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Leach, C.L. et al.: The Toxicologist 9 (No.1), 144 (1989), abstract no. 575NTP Technical Report No. 19, Formic Acid, NIH-Publication 92-3342 (July 1992) More Details published in Zeiger et al. Environ Molec Mutagen. Vol 19 Supplement 21 2-141 (1992); EXTERNAL_SOURCE_ID=61300; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639166_15639265:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_093b91a18717d9a17bf0a46de80692cd |
| ToxValDB HPVIS | NOAEL | =0.06 | mg/L | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Leach, C.L. et al.: The Toxicologist 9 (No.1), 144 (1989), abstract no. 575NTP Technical Report No. 19, Formic Acid, NIH-Publication 92-3342 (July 1992) More Details published in Zeiger et al. Environ Molec Mutagen. Vol 19 Supplement 21 2-141 (1992); EXTERNAL_SOURCE_ID=60772; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639101_15639231:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_817fde6df9c55e1d3aa6de351827369e |
| ToxValDB HPVIS | NOAEL | =120.475 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Leach, C.L. et al.: The Toxicologist 9 (No.1), 144 (1989), abstract no. 575NTP Technical Report No. 19, Formic Acid, NIH-Publication 92-3342 (July 1992) More Details published in Zeiger et al. Environ Molec Mutagen. Vol 19 Supplement 21 2-141 (1992); EXTERNAL_SOURCE_ID=61826; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639230:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5a0f681c24423784d08c8c0bf33ffef9 |
ToxValDB PPRTV (CPHEA) 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | LOAEL (HEC) | =2.7 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=NTP 1992; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1754; TOXICOLOGICAL_EFFECT=neutropenia and increased serum alkaline phosphatase; STUDY_GROUP=PPRTV (CPHEA):15653626:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_04d52fb4973279f9ed4e0295e8f0286b |
| ToxValDB PPRTV (CPHEA) | NOAEL | =277 | mg/kg bw/day | Rat | oral | chronic; 2 years | reproduction developmental | LONG_REF=Malorny 1969; AUTHOR=Malorny; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1754; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=PPRTV (CPHEA):15654079:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d403e0654685233f75311c571d311699 |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.0009 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=NTP 1992; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1754; TOXICOLOGICAL_EFFECT=Neutropenia and increased serum alkaline phosphatase in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653625:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2262e0e9aed7ea49035a672707f652cb |
ToxValDB Pennsylvania DEP ToxValues 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfC | =0.0003 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650135:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e53ca58d9d572a808bba3afe463460d7 |
| ToxValDB Pennsylvania DEP ToxValues | RfD | =0.9 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650134:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_043790a628a033f37b160adfc390db5b |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | developmental toxicity | 945 | mg/kg body weight | rabbit | oral | 21 weeks | developmental toxicity | p.9 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg body weight/day | rat | - | - | reproductive toxicity | p.9 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 0YIW783RG1 | UNII | - | - | - | chemical | - |