NOAEL Studies
Cosmetic Ingredient
Galactomannans NOAEL Studies
INCI: GALACTOMANNANS
CAS: 11078-30-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR_vision_codex 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR_vision_codex | NOAEL | =1 | g/kg/d | rat | oral | 90 days | repeated dose toxicity | {"citation":"54; 2; 4","dose":"An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats.","effect":"ys.54 There were no treatment-related effects on the following: mortality, body weight gain, food consumption, food utilization, hemato- logical parameters, or various biochemical parameters (eg, albumin, cholesterol, and aspartate aminotransferase). Gross examination results were negative, and there were no treatment-related histopathologic changes or effects on weight in the following organs: liver, kidney, spleen, ovaries, and testes. There were also no histopathologic changes in the sto- mach or intestines. An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats. Semirefined cassia gum (in dog food) was administered to 2 groups of 4 male and 4 female Beagle dogs at dietary doses of 1 and 3.5 g/kg/d, respectively, for 90 days.68 The control group received dog food without cassia gum; however, cassia gum was replaced by a substance with similar technological char- acteristics. A dose-related increase in water consumption was the only treatment-related effect noted but was not considered toxicologically significant. Hematologica...","page":17,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_001"} |
| CIR_vision_codex | NOAEL | =0 | ppm | rat | oral | 6 weeks | developmental toxicity | {"citation":"50; 000; (5","dose":"Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum.","effect":"d not reveal any abnormalities that were related to gum administration. There was no evidence of test substance- related abnormalities after external, visceral, and skeletal examinations of fetuses were performed. Additionally, there were no differences in the sex ratios of fetuses or statistically significant differences in fetal body weights. It was concluded that C spinosa gum did not induce maternal toxicity, embry- otoxicity, or teratogenicity. Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum. In a 2-generation reproductive toxicity study (OECD Test Guideline 416), semirefined cassia gum was administered to groups of 25 female Ico: OFA.SD Sprague- Dawley rats (6 weeks old) at dietary concentrations of 0, 5000, 20 000, or 50 000 mg/kg.93 An additional group was fed a diet containing purified semirefined cassia gum (which resulted from an additional isopropano extraction step) at a dose of 50 000 mg/kg. Parental animals were dosed for approx- imately 10 weeks prior to mating and during mating...","page":21,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_002"} |
| CIR_vision_codex | NOAEL | =1000 | mg/kg body weight | rat | oral | - | developmental toxicity | {"citation":"50; 000; 12","dose":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL.","effect":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL. Groups of 12 pregnant female SD rats received oral doses of cassia gum (by gavage) at doses of 0, 250, 500, or 1000 mg/kg body weight per day on days 7 through 16 of gestation.54 There were no treatment-related effects on maternal body weight, the number of resorptions or dead embryos, or the weight and length of fetuses. Also, abnormalities were not observed at skeletal or visceral examination of the fetuses. Therefore, no adverse effects were observed in dams or offspring at doses up to and including 1000 mg/kg body weight per day. The developmental toxicity of semirefined cassia gum (in distilled water) was evaluated using grou","page":22,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_003"} |
| CIR_vision_codex | NOAEL | =1 | g/kg/d | rat | oral | 90 days | repeated dose toxicity | {"citation":"54; 2; 4","dose":"An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats.","effect":"ys.54 There were no treatment-related effects on the following: mortality, body weight gain, food consumption, food utilization, hemato- logical parameters, or various biochemical parameters (eg, albumin, cholesterol, and aspartate aminotransferase). Gross examination results were negative, and there were no treatment-related histopathologic changes or effects on weight in the following organs: liver, kidney, spleen, ovaries, and testes. There were also no histopathologic changes in the sto- mach or intestines. An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats. Semirefined cassia gum (in dog food) was administered to 2 groups of 4 male and 4 female Beagle dogs at dietary doses of 1 and 3.5 g/kg/d, respectively, for 90 days.68 The control group received dog food without cassia gum; however, cassia gum was replaced by a substance with similar technological char- acteristics. A dose-related increase in water consumption was the only treatment-related effect noted but was not considered toxicologically significant. Hematologica...","page":17,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_001"} |
| CIR_vision_codex | NOAEL | =0 | ppm | rat | oral | 6 weeks | developmental toxicity | {"citation":"50; 000; (5","dose":"Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum.","effect":"d not reveal any abnormalities that were related to gum administration. There was no evidence of test substance- related abnormalities after external, visceral, and skeletal examinations of fetuses were performed. Additionally, there were no differences in the sex ratios of fetuses or statistically significant differences in fetal body weights. It was concluded that C spinosa gum did not induce maternal toxicity, embry- otoxicity, or teratogenicity. Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum. In a 2-generation reproductive toxicity study (OECD Test Guideline 416), semirefined cassia gum was administered to groups of 25 female Ico: OFA.SD Sprague- Dawley rats (6 weeks old) at dietary concentrations of 0, 5000, 20 000, or 50 000 mg/kg.93 An additional group was fed a diet containing purified semirefined cassia gum (which resulted from an additional isopropano extraction step) at a dose of 50 000 mg/kg. Parental animals were dosed for approx- imately 10 weeks prior to mating and during mating...","page":21,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_002"} |
| CIR_vision_codex | NOAEL | =1000 | mg/kg body weight | rat | oral | - | developmental toxicity | {"citation":"50; 000; 12","dose":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL.","effect":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL. Groups of 12 pregnant female SD rats received oral doses of cassia gum (by gavage) at doses of 0, 250, 500, or 1000 mg/kg body weight per day on days 7 through 16 of gestation.54 There were no treatment-related effects on maternal body weight, the number of resorptions or dead embryos, or the weight and length of fetuses. Also, abnormalities were not observed at skeletal or visceral examination of the fetuses. Therefore, no adverse effects were observed in dams or offspring at doses up to and including 1000 mg/kg body weight per day. The developmental toxicity of semirefined cassia gum (in distilled water) was evaluated using grou","page":22,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_003"} |
| CIR_vision_codex | NOAEL | =1 | g/kg/d | rat | oral | 90 days | repeated dose toxicity | {"citation":"54; 2; 4","dose":"An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats.","effect":"ys.54 There were no treatment-related effects on the following: mortality, body weight gain, food consumption, food utilization, hemato- logical parameters, or various biochemical parameters (eg, albumin, cholesterol, and aspartate aminotransferase). Gross examination results were negative, and there were no treatment-related histopathologic changes or effects on weight in the following organs: liver, kidney, spleen, ovaries, and testes. There were also no histopathologic changes in the sto- mach or intestines. An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats. Semirefined cassia gum (in dog food) was administered to 2 groups of 4 male and 4 female Beagle dogs at dietary doses of 1 and 3.5 g/kg/d, respectively, for 90 days.68 The control group received dog food without cassia gum; however, cassia gum was replaced by a substance with similar technological char- acteristics. A dose-related increase in water consumption was the only treatment-related effect noted but was not considered toxicologically significant. Hematologica...","page":17,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_001"} |
| CIR_vision_codex | NOAEL | =0 | ppm | rat | oral | 6 weeks | developmental toxicity | {"citation":"50; 000; (5","dose":"Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum.","effect":"d not reveal any abnormalities that were related to gum administration. There was no evidence of test substance- related abnormalities after external, visceral, and skeletal examinations of fetuses were performed. Additionally, there were no differences in the sex ratios of fetuses or statistically significant differences in fetal body weights. It was concluded that C spinosa gum did not induce maternal toxicity, embry- otoxicity, or teratogenicity. Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum. In a 2-generation reproductive toxicity study (OECD Test Guideline 416), semirefined cassia gum was administered to groups of 25 female Ico: OFA.SD Sprague- Dawley rats (6 weeks old) at dietary concentrations of 0, 5000, 20 000, or 50 000 mg/kg.93 An additional group was fed a diet containing purified semirefined cassia gum (which resulted from an additional isopropano extraction step) at a dose of 50 000 mg/kg. Parental animals were dosed for approx- imately 10 weeks prior to mating and during mating...","page":21,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_002"} |
| CIR_vision_codex | NOAEL | =1000 | mg/kg body weight | rat | oral | - | developmental toxicity | {"citation":"50; 000; 12","dose":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL.","effect":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL. Groups of 12 pregnant female SD rats received oral doses of cassia gum (by gavage) at doses of 0, 250, 500, or 1000 mg/kg body weight per day on days 7 through 16 of gestation.54 There were no treatment-related effects on maternal body weight, the number of resorptions or dead embryos, or the weight and length of fetuses. Also, abnormalities were not observed at skeletal or visceral examination of the fetuses. Therefore, no adverse effects were observed in dams or offspring at doses up to and including 1000 mg/kg body weight per day. The developmental toxicity of semirefined cassia gum (in distilled water) was evaluated using grou","page":22,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_003"} |
| CIR_vision_codex | NOAEL | =1 | g/kg/d | rat | oral | 90 days | repeated dose toxicity | {"citation":"54; 2; 4","dose":"An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats.","effect":"ys.54 There were no treatment-related effects on the following: mortality, body weight gain, food consumption, food utilization, hemato- logical parameters, or various biochemical parameters (eg, albumin, cholesterol, and aspartate aminotransferase). Gross examination results were negative, and there were no treatment-related histopathologic changes or effects on weight in the following organs: liver, kidney, spleen, ovaries, and testes. There were also no histopathologic changes in the sto- mach or intestines. An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats. Semirefined cassia gum (in dog food) was administered to 2 groups of 4 male and 4 female Beagle dogs at dietary doses of 1 and 3.5 g/kg/d, respectively, for 90 days.68 The control group received dog food without cassia gum; however, cassia gum was replaced by a substance with similar technological char- acteristics. A dose-related increase in water consumption was the only treatment-related effect noted but was not considered toxicologically significant. Hematologica...","page":17,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_001"} |
| CIR_vision_codex | NOAEL | =0 | ppm | rat | oral | 6 weeks | developmental toxicity | {"citation":"50; 000; (5","dose":"Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum.","effect":"d not reveal any abnormalities that were related to gum administration. There was no evidence of test substance- related abnormalities after external, visceral, and skeletal examinations of fetuses were performed. Additionally, there were no differences in the sex ratios of fetuses or statistically significant differences in fetal body weights. It was concluded that C spinosa gum did not induce maternal toxicity, embry- otoxicity, or teratogenicity. Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum. In a 2-generation reproductive toxicity study (OECD Test Guideline 416), semirefined cassia gum was administered to groups of 25 female Ico: OFA.SD Sprague- Dawley rats (6 weeks old) at dietary concentrations of 0, 5000, 20 000, or 50 000 mg/kg.93 An additional group was fed a diet containing purified semirefined cassia gum (which resulted from an additional isopropano extraction step) at a dose of 50 000 mg/kg. Parental animals were dosed for approx- imately 10 weeks prior to mating and during mating...","page":21,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_002"} |
| CIR_vision_codex | NOAEL | =1000 | mg/kg body weight | rat | oral | - | developmental toxicity | {"citation":"50; 000; 12","dose":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL.","effect":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL. Groups of 12 pregnant female SD rats received oral doses of cassia gum (by gavage) at doses of 0, 250, 500, or 1000 mg/kg body weight per day on days 7 through 16 of gestation.54 There were no treatment-related effects on maternal body weight, the number of resorptions or dead embryos, or the weight and length of fetuses. Also, abnormalities were not observed at skeletal or visceral examination of the fetuses. Therefore, no adverse effects were observed in dams or offspring at doses up to and including 1000 mg/kg body weight per day. The developmental toxicity of semirefined cassia gum (in distilled water) was evaluated using grou","page":22,"pdf":"PRS600.pdf","row_type":"noael_study","study_id":"PRS600_noael_003"} |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOEL | =230 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=EFSA AFC (2006). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to an application on the use of cassia gum as a food additive. doi:10.2903/j.efsa.2006.389.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to an application on the use of cassia gum as a food additive; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2006.389; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15614260:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_492908d73a8648887f0e00bb37ab4528 |
UnifiedCodex:CIR:beta.noael_studies 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 0 | ppm | rat | oral | 6 weeks | developmental toxicity | SOURCE_SUBDIR=PRS600; REPORT_TITLE=Safety Assessment of Galactomannans as Used in Cosmetics Wilbur Johnson Jr1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks Jr3, Ronald C. Shank3,; OPINION_NUMBER=PRS600; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Toxicology 2015; VALUE_TEXT=000; DOSE=Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum.; EFFECT=d not reveal any abnormalities that were related to gum administration. There was no evidence of test substance- related abnormalities after external, visceral, and skeletal examinations of fetuses were performed. Additionally, there were no differences in the sex ratios of fetuses or statistically significant differences in fetal body weights. It was concluded that C spinosa gum did not induce maternal toxicity, embry- otoxicity, or teratogenicity. Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum. In a 2-generation reproductive toxicity study (OECD Test Guideline 416), semirefined cassia gum was administered to groups of 25 female Ico: OFA.SD Sprague- Dawley rats (6 weeks old) at dietary concentrations of 0, 5000, 20 000, or 50 000 mg/kg.93 An additional group was fed a diet containing purified semirefined cassia gum (which resulted from an additional isopropano extraction step) at a dose of 50 000 mg/kg. Parental animals were dosed for approx- imately 10 weeks prior to mating and during mating...; CITATION=50; 000; (5; CITATION_NUMBERS=[50,5]; REFERENCE=50; 000; (5; DETAILS_JSON={"cas_number":"9000-30-0","citation":"50; 000; (5","dose":"Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum.","duration":"6 weeks","effect":"d not reveal any abnormalities that were related to gum administration. There was no evidence of test substance- related abnormalities after external, visceral, and skeletal examinations of fetuses were performed. Additionally, there were no differences in the sex ratios of fetuses or statistically significant differences in fetal body weights. It was concluded that C spinosa gum did not induce maternal toxicity, embry- otoxicity, or teratogenicity. Based on the results from this study and the preceding study, the NOAEL was considered to be >50 000 ppm (5%) in the diet.92 Cassia gum. In a 2-generation reproductive toxicity study (OECD Test Guideline 416), semirefined cassia gum was administered to groups of 25 female Ico: OFA.SD Sprague- Dawley rats (6 weeks old) at dietary concentrations of 0, 5000, 20 000, or 50 000 mg/kg.93 An additional group was fed a diet containing purified semirefined cassia gum (which resulted from an additional isopropano extraction step) at a dose of 50 000 mg/kg. Parental animals were dosed for approx- imately 10 weeks prior to mating and during mating...","endpoint":"developmental toxicity","ingredient":"Galactomannans","loael_value":"","noael_unit":"ppm","noael_value":"000","page":21,"route":"oral","species":"rat","study_id":"PRS600_noael_002"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 1000 | mg/kg body weight | rat | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS600; REPORT_TITLE=Safety Assessment of Galactomannans as Used in Cosmetics Wilbur Johnson Jr1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks Jr3, Ronald C. Shank3,; OPINION_NUMBER=PRS600; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Toxicology 2015; VALUE_TEXT=1000; DOSE=These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL.; EFFECT=These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL. Groups of 12 pregnant female SD rats received oral doses of cassia gum (by gavage) at doses of 0, 250, 500, or 1000 mg/kg body weight per day on days 7 through 16 of gestation.54 There were no treatment-related effects on maternal body weight, the number of resorptions or dead embryos, or the weight and length of fetuses. Also, abnormalities were not observed at skeletal or visceral examination of the fetuses. Therefore, no adverse effects were observed in dams or offspring at doses up to and including 1000 mg/kg body weight per day. The developmental toxicity of semirefined cassia gum (in distilled water) was evaluated using grou; CITATION=50; 000; 12; CITATION_NUMBERS=[50,12]; REFERENCE=50; 000; 12; DETAILS_JSON={"cas_number":"9000-30-0","citation":"50; 000; 12","dose":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL.","duration":"","effect":"These effects were observed at the highest dose level (both groups), and therefore, 50 000 mg/kg feed (equal to 5280 mg/kg body weight per day) was considered the no- observed-effect level NOEL. Groups of 12 pregnant female SD rats received oral doses of cassia gum (by gavage) at doses of 0, 250, 500, or 1000 mg/kg body weight per day on days 7 through 16 of gestation.54 There were no treatment-related effects on maternal body weight, the number of resorptions or dead embryos, or the weight and length of fetuses. Also, abnormalities were not observed at skeletal or visceral examination of the fetuses. Therefore, no adverse effects were observed in dams or offspring at doses up to and including 1000 mg/kg body weight per day. The developmental toxicity of semirefined cassia gum (in distilled water) was evaluated using grou","endpoint":"developmental toxicity","ingredient":"Galactomannans","loael_value":"","noael_unit":"mg/kg body weight","noael_value":"1000","page":22,"route":"oral","species":"rat","study_id":"PRS600_noael_003"} |
| UnifiedCodex:CIR:beta.noael_studies | repeated dose toxicity | 1 | g/kg/d | rat | oral | 90 days | repeated dose toxicity | SOURCE_SUBDIR=PRS600; REPORT_TITLE=Safety Assessment of Galactomannans as Used in Cosmetics Wilbur Johnson Jr1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks Jr3, Ronald C. Shank3,; OPINION_NUMBER=PRS600; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Toxicology 2015; VALUE_TEXT=1; 3.5; DOSE=An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats.; EFFECT=ys.54 There were no treatment-related effects on the following: mortality, body weight gain, food consumption, food utilization, hemato- logical parameters, or various biochemical parameters (eg, albumin, cholesterol, and aspartate aminotransferase). Gross examination results were negative, and there were no treatment-related histopathologic changes or effects on weight in the following organs: liver, kidney, spleen, ovaries, and testes. There were also no histopathologic changes in the sto- mach or intestines. An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats. Semirefined cassia gum (in dog food) was administered to 2 groups of 4 male and 4 female Beagle dogs at dietary doses of 1 and 3.5 g/kg/d, respectively, for 90 days.68 The control group received dog food without cassia gum; however, cassia gum was replaced by a substance with similar technological char- acteristics. A dose-related increase in water consumption was the only treatment-related effect noted but was not considered toxicologically significant. Hematologica...; CITATION=54; 2; 4; CITATION_NUMBERS=[54,2,4]; REFERENCE=54; 2; 4; DETAILS_JSON={"cas_number":"9000-30-0","citation":"54; 2; 4","dose":"An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats.","duration":"90 days","effect":"ys.54 There were no treatment-related effects on the following: mortality, body weight gain, food consumption, food utilization, hemato- logical parameters, or various biochemical parameters (eg, albumin, cholesterol, and aspartate aminotransferase). Gross examination results were negative, and there were no treatment-related histopathologic changes or effects on weight in the following organs: liver, kidney, spleen, ovaries, and testes. There were also no histopathologic changes in the sto- mach or intestines. An no-observable-adverse-effect-level (NOAEL) of 1000 mg/kg body weight was reported for cassia gum in rats. Semirefined cassia gum (in dog food) was administered to 2 groups of 4 male and 4 female Beagle dogs at dietary doses of 1 and 3.5 g/kg/d, respectively, for 90 days.68 The control group received dog food without cassia gum; however, cassia gum was replaced by a substance with similar technological char- acteristics. A dose-related increase in water consumption was the only treatment-related effect noted but was not considered toxicologically significant. Hematologica...","endpoint":"repeated dose toxicity","ingredient":"Galactomannans","loael_value":"","noael_unit":"g/kg/d","noael_value":"1; 3.5","page":17,"route":"oral","species":"rat","study_id":"PRS600_noael_001"} |