NOAEL Studies Cosmetic Ingredient

Galactomannans NOAEL Studies

INCI: GALACTOMANNANS

CAS: 11078-30-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =1 g/kg/d rat oral 90 days repeated dose toxicity 54; 2; 4, p.17
CIR Safety Assessment NOAEL =0 ppm rat oral 6 weeks developmental toxicity 50; 000; (5, p.21
CIR Safety Assessment NOAEL =1000 mg/kg body weight rat oral - developmental toxicity 50; 000; 12, p.22
EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOEL =230 mg/kg bw/day Rat oral short-term; 28 days short-term LONG_REF=EFSA AFC (2006). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to an application on the use of cassia gum as a food additive. doi:10.2903/j.efsa.2006.389.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to an application on the use of cassia gum as a food additive; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2006.389; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15614260:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_492908d73a8648887f0e00bb37ab4528
Regulatory source 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 0 ppm rat oral 6 weeks developmental toxicity p.21
Regulatory source developmental toxicity 1000 mg/kg body weight rat oral - developmental toxicity p.22
Regulatory source repeated dose toxicity 1 g/kg/d rat oral 90 days repeated dose toxicity p.17