Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Gamma-Caprolactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.750 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.750 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Not expected to be phototoxic or photoallergenic; not PBT per IFRA Environmental Standards; environmental risk quotients below concern thresholds.
Regulatory Flags
Frequently Asked Questions
Is Gamma-Caprolactone safe in cosmetics?
Not expected to be phototoxic or photoallergenic; not PBT per IFRA Environmental Standards; environmental risk quotients below concern thresholds. The EU classifies Gamma-Caprolactone as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Gamma-Caprolactone allowed in the EU?
Gamma-Caprolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Gamma-Caprolactone do in cosmetics?
Gamma-Caprolactone functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 695-06-7.
What is the Margin of Safety for Gamma-Caprolactone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Gamma-Caprolactone?
The NOAEL (No Observed Adverse Effect Level) for Gamma-Caprolactone is ca.750 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
Check Gamma-Caprolactone compliance across multiple jurisdictions:
Related Ingredients
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