NOAEL Studies Cosmetic Ingredient

Gamma-Cyclodextrin NOAEL Studies

INCI: GAMMA-CYCLODEXTRIN

CAS: 17465-86-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9906; RecordID=ARPathway2016_937; DatasetName=ARPathway2016; DTXSID=DTXSID5047033; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5047033
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL >3750 mg/kg bw/day Rat injection - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c78e4b096bca877216d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10815/7/3/5?documentUUID=f50ab308-94ef-4b0d-a4c0-0355ebe038f4; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15815451:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2f00069b36628e0cba542feb15209c18
ToxValDB_ECHA_IUCLID LEL >4600 mg/kg bw/day Rat injection - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c14e4b096bca877095b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10815/7/3/5?documentUUID=f50ab308-94ef-4b0d-a4c0-0355ebe038f4; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15815225:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_65afabe2a977f019f51f409096863a5f
ToxValDB_ECHA_IUCLID LEL =10000 mg/kg bw/day Mouse injection - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c56e4b096bca8771a1f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10815/7/3/5?documentUUID=f50ab308-94ef-4b0d-a4c0-0355ebe038f4; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15815388:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d2ff5eb446262b201aede0ab1e925b7
ToxValDB_ECHA_IUCLID NOAEL =120 mg/kg bw/day Rat injection subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c62039e4b096bca878082f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10815/7/6/5?documentUUID=f50ab308-94ef-4b0d-a4c0-0355ebe038f4; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15852196:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9758583ecbd5644d46aa6ee889abf6d2
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier KZJ0BYZ5VA UNII - - - chemical {"approval_status":null,"molecular_formula":"C48H80O40","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KZJ0BYZ5VA"}
openFDA substances FDA UNII substance identifier KZJ0BYZ5VA UNII - - - chemical {"approval_status":null,"molecular_formula":"C48H80O40","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KZJ0BYZ5VA"}
openFDA substances FDA UNII substance identifier KZJ0BYZ5VA UNII - - - chemical {"approval_status":null,"molecular_formula":"C48H80O40","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KZJ0BYZ5VA"}
openFDA substances FDA UNII substance identifier KZJ0BYZ5VA UNII - - - chemical {"approval_status":null,"molecular_formula":"C48H80O40","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KZJ0BYZ5VA"}