gamma-Methylbenzenehexanenitrile

INCI: GAMMA-METHYLBENZENEHEXANENITRILE

CAS Number
Requires verification — not widely catalogued in public databases
Function
Fragrance (aromatic nitrile)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Presumed permitted as fragrance under 21 CFR 700.3(e)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Significant data gap: No public RIFM, CIR, or SCCS assessment found. Nitrile group requires specific evaluation for metabolic fate and potential HCN release (unlikely at cosmetic levels for stable aliphatic nitriles but must be documented). Recommend obtaining full supplier safety dossier, DPRA/h-CLAT/KeratinoSens in vitro sensitization battery, Ames test or in silico genotoxicity assessment. Cannot complete CPSR Part B without additional data.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is gamma-Methylbenzenehexanenitrile safe in cosmetics?

Significant data gap: No public RIFM, CIR, or SCCS assessment found. Nitrile group requires specific evaluation for metabolic fate and potential HCN release (unlikely at cosmetic levels for stable aliphatic nitriles but must be documented). Recommend obtaining full supplier safety dossier, DPRA/h-CLAT/KeratinoSens in vitro sensitization battery, Ames test or in silico genotoxicity assessment. Cannot complete CPSR Part B without additional data. The EU classifies gamma-Methylbenzenehexanenitrile as "prohibited". Safety rating: MODERATE.

Is gamma-Methylbenzenehexanenitrile allowed in the EU?

gamma-Methylbenzenehexanenitrile EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does gamma-Methylbenzenehexanenitrile do in cosmetics?

gamma-Methylbenzenehexanenitrile functions as: Fragrance (aromatic nitrile). It is classified as a cosmetic ingredient in our database. CAS number: Requires verification — not widely catalogued in public databases.

What is the Margin of Safety for gamma-Methylbenzenehexanenitrile?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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