Garcinia hanburyi Sap Powder

INCI: GARCINIA HANBURYI SAP POWDER

CAS Number
Not established for crude sap; primary active gambogic acid CAS: 2752-65-0
Function
Skin conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted by default โ€” no specific CFR prohibition, but GHS hazard classifications apply

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Gamboge resin contains gambogic acid classified as toxic and carcinogenic/teratogenic with Acute Toxicity Cat. 3 (oral), liver and kidney toxicity demonstrated in rat studies, and respiratory system as target organ; caged polyprenylated xanthones are cytotoxic and pro-apoptotic; this ingredient functions as a pharmacological agent rather than a conventional cosmetic raw material and will likely be flagged as unacceptable in cosmetic product safety assessment without extensive justification and strict dose limitations.

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Concern Level: High

Frequently Asked Questions

Is Garcinia hanburyi Sap Powder safe in cosmetics?

Gamboge resin contains gambogic acid classified as toxic and carcinogenic/teratogenic with Acute Toxicity Cat. 3 (oral), liver and kidney toxicity demonstrated in rat studies, and respiratory system as target organ; caged polyprenylated xanthones are cytotoxic and pro-apoptotic; this ingredient functions as a pharmacological agent rather than a conventional cosmetic raw material and will likely be flagged as unacceptable in cosmetic product safety assessment without extensive justification and strict dose limitations. The EU classifies Garcinia hanburyi Sap Powder as "permitted". Safety rating: POOR.

Is Garcinia hanburyi Sap Powder allowed in the EU?

Garcinia hanburyi Sap Powder EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Garcinia hanburyi Sap Powder do in cosmetics?

Garcinia hanburyi Sap Powder functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not established for crude sap; primary active gambogic acid CAS: 2752-65-0.

What is the Margin of Safety for Garcinia hanburyi Sap Powder?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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