NOAEL Studies Active Ingredient

Genistein NOAEL Studies

INCI: GENISTEIN

CAS: 446-72-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE adme parameters 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 68 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=1989; Record_ID=adme_parameters_345; Data_Type=Measured; DTXSID=DTXSID5022308; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=68.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE adme parameters Clint 18.69 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=1990; Record_ID=adme_parameters_345; Data_Type=Measured; DTXSID=DTXSID5022308; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=18.69; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE adme parameters Fu 0.0085 fraction Rat - - Measured; httk, Rat Plasma Fraction Unbound sheet=Data; excel_row=1987; Record_ID=adme_parameters_345; Data_Type=Measured; DTXSID=DTXSID5022308; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.0085; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE adme parameters Fu 0.02426 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=1988; Record_ID=adme_parameters_345; Data_Type=Measured; DTXSID=DTXSID5022308; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.02426; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer POLY-3 lowest dose 500 ppm Rat Dosed feed - In Vivo; Two year cancer bioassay sheet=Data; excel_row=5853; Record_ID=cancer_1621; Data_Type=In Vivo; Formulation_Name=Genistein; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=500; Response_Unit=ppm; Species=Rat; Strain=Sprague Dawley; Sex=Female; Route=Dosed feed; Level_of_Evidence=Some evidence; Tissue=Pituitary gland; Location=Pars distalis or unspecified site; Lesion=Carcinoma or adenoma; Reference=TR-545; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr545/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE cancer Top dose 500 ppm Rat Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=5852; Record_ID=cancer_1619; Data_Type=In Vivo; Formulation_Name=Genistein; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=500; Response_Unit=ppm; Species=Rat; Strain=Sprague Dawley; Sex=Male; Route=Dosed feed; Reference=TR-545; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr545/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine 56 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 0.33676788105873 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9958; RecordID=ERPathway2016_156; DatasetName=ERPathway2016; DTXSID=DTXSID5022308; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=0.33676788105873; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine AC50/EC50/IC50 84500 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=128; Record_ID=endocrine_invitro_122; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=84500; Reported_Response_Unit=nM; Response=84500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine AC50/EC50/IC50 100000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=131; Record_ID=endocrine_invitro_125; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=100000; Reported_Response_Unit=nM; Response=100000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Pfitscher et al. 2008; 18809497; 10.1016/j.jsbmb.2008.08.007; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine AC50/EC50/IC50 3.7 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=191; Record_ID=endocrine_invitro_185; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1000; Reported_Response_Unit=ng/L; Conversion_Factor=Molecular Weight; Conversion_Factor_Value=270.24; Conversion_Factor_Source=EPA Dashboard; Converted_Response=3.7004144464179989; Converted_Response_Unit=nM; Response=3.7; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine AC50/EC50/IC50 140000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=232; Record_ID=endocrine_invitro_226; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=140000; Reported_Response_Unit=nM; Response=140000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Ahr 2004; 14751668; 10.1016/j.tox.2003.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine AC50/EC50/IC50 155000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=233; Record_ID=endocrine_invitro_227; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=155000; Reported_Response_Unit=nM; Response=155000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Ahr 2004; 14751668; 10.1016/j.tox.2003.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine AC50/EC50/IC50 270000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=478; Record_ID=endocrine_invitro_472; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=270000; Reported_Response_Unit=nM; Response=270000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ichige et al. 2013; 23402539; 10.1021/jf305233t; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine AC50/EC50/IC50 239.9 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7847; Record_ID=endocrine_invitro_3468; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=239.88329189999999; Reported_Response_Unit=nM; Response=239.9; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bartonkova et al. 2015; 25811655; 10.1371/journal.pone.0121316; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine AC50/EC50/IC50 162.2 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7848; Record_ID=endocrine_invitro_3469; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=162.1810097; Reported_Response_Unit=nM; Response=162.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bartonkova et al. 2015; 25811655; 10.1371/journal.pone.0121316; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine AC50/EC50/IC50 1300000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13274; Record_ID=endocrine_invitro_4113; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=1300000; Reported_Response_Unit=nM; Response=1300000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine ACC 0.0615586769783145 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9959; RecordID=ERPathway2016_156; DatasetName=ERPathway2016; DTXSID=DTXSID5022308; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=0.0615586769783145; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine EC50 271 nM - - - In Vitro; ER Transactivation-Agonist (VM7Luc Assay) sheet=Data_invitro; excel_row=16617; Record_ID=endocrine_invitro_4456; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=ER Transactivation-Agonist (VM7Luc Assay); Endpoint=EC50; Reported_Response=2.7099999999999998E-7; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=270.99999999999903; Converted_Response_Unit=nM; Response=271; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LEL 10000 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10384; Record_ID=endocrine_invitro_3665; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=10000; Reported_Response_Unit=nM; Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Stroheker et al. 2004; 15110097; 10.1016/j.fct.2004.01.012; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LEL 500 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10847; Record_ID=endocrine_invitro_3655; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=500; Reported_Response_Unit=nM; Response=500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LEL 1 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14871; Record_ID=endocrine_invitro_4243; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=1; Reported_Response_Unit=nM; Response=1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Stroheker et al. 2004; 15110097; 10.1016/j.fct.2004.01.012; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LEL 10 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=15018; Record_ID=endocrine_invitro_4254; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=10; Reported_Response_Unit=nM; Response=10; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LEL 100000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=15043; Record_ID=endocrine_invitro_4238; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=100000; Reported_Response_Unit=nM; Response=100000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Gao et al. 2004; 15042621; 10.1002/pros.10375; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 20 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=819; Record_ID=endocrine_invivo_132; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=20; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=20; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Yamasaki et al. 2002; 12415423; 10.1007/s00204-002-0383-1|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 100 mg/kg bw/day Rat Oral Treatment_Duration=4 days; Age_at_First_Dose=PND 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=820; Record_ID=endocrine_invivo_127; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Oral; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Stroheker et al. 2003; 12849853; 10.1016/s0890-6238(03)00044-3|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 15 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=821; Record_ID=endocrine_invivo_135; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=15; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=80; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 10 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=825; Record_ID=endocrine_invivo_145; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=10; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=10; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 6; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 60 mg/kg bw/day Rat Oral Treatment_Duration=7 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=828; Record_ID=endocrine_invivo_118; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=60; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Oral; Maximum_Dose=300; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol D; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 2.5 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=5 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=830; Record_ID=endocrine_invivo_120; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=2.5; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=10; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 2; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 200 mg/kg bw/day Mouse Oral Treatment_Duration=7 days; Age_at_First_Dose=PND 56; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=2 weeks; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=831; Record_ID=endocrine_invivo_122; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=200; Response_Unit=mg/kg/day; Species=Mouse; Reported_Strain=C57BL/6J; Strain=C57BL/6; Sex=Female (ovariectomized); Route=Oral; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Ohta et al. 2012; 23037998; 10.2131/jts.37.879|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 1 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=838; Record_ID=endocrine_invivo_128; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=1; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=80; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 5 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=842; Record_ID=endocrine_invivo_131; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=5; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=20; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Yamasaki et al. 2002; 12415423; 10.1007/s00204-002-0383-1|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine LOEL 35 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=847; Record_ID=endocrine_invivo_136; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=35; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=50; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9954; RecordID=ARPathway2016_1213; DatasetName=ARPathway2016; DTXSID=DTXSID5022308; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Model Score 0.538 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=9960; RecordID=ERPathway2016_156; DatasetName=ERPathway2016; DTXSID=DTXSID5022308; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.538; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine PC50 24.5 nM - - - In Vitro; ER Transactivation-Agonist (STTA Assay) sheet=Data_invitro; excel_row=16526; Record_ID=endocrine_invitro_4456; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=ER Transactivation-Agonist (STTA Assay); Endpoint=PC50; Reported_Response=2.4500000000000001E-8; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=24.5; Converted_Response_Unit=nM; Response=24.5; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine RBA 0.003631 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1896; Record_ID=endocrine_invitro_655; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=RBA; Reported_Response=-2.44; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=3.630780547701011E-3; Converted_Response_Unit=Unitless; Response=0.003631; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Hong et al. 2003; 14758981; 10.1080/10629360310001623962; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine RBA 0.0039 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2075; Record_ID=endocrine_invitro_226; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=RBA; Reported_Response=3.8999999999999998E-3; Reported_Response_Unit=Unitless; Response=0.0039; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Ahr 2004; 14751668; 10.1016/j.tox.2003.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine RBA 0.0029 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2076; Record_ID=endocrine_invitro_227; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=RBA; Reported_Response=2.8999999999999998E-3; Reported_Response_Unit=Unitless; Response=0.0029; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Ahr 2004; 14751668; 10.1016/j.tox.2003.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine RBA 0.0036 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2077; Record_ID=endocrine_invitro_122; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=AR Binding; Endpoint=RBA; Reported_Response=3.5999999999999999E-3; Reported_Response_Unit=Unitless; Response=0.0036; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 200 % Rat Oral Treatment_Duration=4 days; Age_at_First_Dose=PND 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=466; Record_ID=endocrine_invivo_127; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=200; Response_Unit=%; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Oral; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Stroheker et al. 2003; 12849853; 10.1016/s0890-6238(03)00044-3|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 179 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=468; Record_ID=endocrine_invivo_130; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=179; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=80; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 250 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=469; Record_ID=endocrine_invivo_132; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=250; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=20; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Yamasaki et al. 2002; 12415423; 10.1007/s00204-002-0383-1|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 153 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=471; Record_ID=endocrine_invivo_135; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=153; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=80; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 157 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=473; Record_ID=endocrine_invivo_137; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=157; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=80; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 210 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=476; Record_ID=endocrine_invivo_140; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=210; Response_Unit=%; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=750; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Zhang et al. 2008; 19239007; Not available|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 167 % Rat Subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=477; Record_ID=endocrine_invivo_142; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=167; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=80; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol D; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 180 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=478; Record_ID=endocrine_invivo_145; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=180; Response_Unit=%; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=10; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 6; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 136 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=480; Record_ID=endocrine_invivo_117; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=136; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=500; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 183 % Rat Oral Treatment_Duration=7 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=481; Record_ID=endocrine_invivo_118; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=183; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Oral; Maximum_Dose=300; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol D; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 120 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=5 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=483; Record_ID=endocrine_invivo_120; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=120; Response_Unit=%; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=10; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 2; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 260 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=485; Record_ID=endocrine_invivo_123; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=260; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=20; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Yamasaki et al. 2002; 12415423; 10.1007/s00204-002-0383-1|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 148 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=487; Record_ID=endocrine_invivo_125; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=148; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=50; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 118 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=491; Record_ID=endocrine_invivo_128; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=118; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=80; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 230 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=495; Record_ID=endocrine_invivo_131; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=230; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=20.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 245 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=497; Record_ID=endocrine_invivo_133; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=245; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Yamasaki et al. 2002; 11750080; 10.1016/s0300-483x(01)00505-4|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 249 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=502; Record_ID=endocrine_invivo_134; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=249; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=300.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 156 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=506; Record_ID=endocrine_invivo_136; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=156; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=50; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 161 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=509; Record_ID=endocrine_invivo_138; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=161; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:ApfSD; Strain=Alderley Park; Sex=Female; Route=Oral; Maximum_Dose=500; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 240 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=511; Record_ID=endocrine_invivo_139; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=240; Response_Unit=%; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=50; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 1; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 206 % Rat Subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=514; Record_ID=endocrine_invivo_141; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=206; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=80; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol D; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
NTP ICE endocrine Uterine weight increase vs control 142 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=519; Record_ID=endocrine_invivo_144; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5022308; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=142; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=500; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022308; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5022308
SCCS Opinion 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.02 % rat oral developmental reproductive toxicity p.71
SCCS Opinion NOAEL =0.3 % rat - developmental reproductive toxicity p.37
SCCS Opinion NOAEL =4 mg/kg bw/day - oral 2 weeks NOAEL study p.32
SCCS Opinion NOAEL =5 mg/kg bw/d human - - reproductive toxicity p.37
SCCS Opinion NOAEL =5 mg/kg rat oral - reproductive toxicity p.71
SCCS Opinion NOAEL =5 - rat - 30 days NOAEL study p.153
SCCS Opinion NOAEL =7.4 mg/kg bw human oral - NOAEL study p.70
SCCS Opinion NOAEL =15 mg/kg bw - oral - NOAEL study p.119
SCCS Opinion NOAEL =16 mg/kg bw/d pig oral Chronic carcinogenicity p.28
SCCS Opinion NOAEL =19 mg/kg bw/d rat oral - reproductive toxicity p.34
SCCS Opinion NOAEL =20 - - - - NOAEL study p.119
SCCS Opinion NOAEL =25 % human oral - NOAEL study p.70
SCCS Opinion NOAEL =35 mg/kg rat - 3 months reproductive toxicity p.67
SCCS Opinion NOAEL =40 mg/kg/day - - - NOAEL study p.32
SCCS Opinion NOAEL =50 mg/kg/day - - 13 weeks reproductive toxicity p.60
SCCS Opinion NOAEL =100 mg/kg bw/d pig oral 28-day repeated dose toxicity p.27
SCCS Opinion NOAEL =100 ppm rat oral developmental reproductive toxicity p.37
SCCS Opinion NOAEL =100 % rat oral 90-day NOAEL study p.72
SCCS Opinion NOAEL =119 - - - - NOAEL study p.119
SCCS Opinion NOAEL =1250 ppm - oral - NOAEL study p.119
SCCS Opinion NOAEL =2000 mg/kg bw/day rat - developmental developmental toxicity p.37
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOEL =50 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0deee4b0a676289de876; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Body Weight Changes: decrease|Food Consumption: decrease|Hematology: RBC decrease, Ret increase, , Hgb decrease|Blood Chemistry: gamma-GTP increase, , Cho decrease, TP decrease; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|hematology; STUDY_GROUP=HESS:15638543:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9e202fd70154e0290403826d4288f81e
ToxValDB Uterotrophic Hershberger DB 30 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Uterotrophic Hershberger DB LEL =100 mg/kg bw/day Rat oral short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713265_15713463_15713534_15713575_15713579_15713610:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0acad158d3a7ef6804a97253a36db2b8
ToxValDB Uterotrophic Hershberger DB LEL =0.62 mg Rat injection acute; 1 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713287:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_37e7e9ce594e3c95fd0667a19c7a5c6d
ToxValDB Uterotrophic Hershberger DB LEL =5.77 mg Mouse oral short-term; 6 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713298:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_35988c9512ed126434fd60506256f120
ToxValDB Uterotrophic Hershberger DB LEL =1.25 mg/day Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713350:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_300630ae3524427436e582b157500e1d
ToxValDB Uterotrophic Hershberger DB LEL =2 mg/day Mouse injection short-term; 4 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713355:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3917739ddbe32455025e1a7f8bf31f9b
ToxValDB Uterotrophic Hershberger DB LEL =2.5 mg/day Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713359_15713370:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d5d927360d5a67af2817106a4beab58
ToxValDB Uterotrophic Hershberger DB LEL =3 mg/day Mouse injection short-term; 14 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713357_15713363_15713367:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b7e3c3a234e21a8b30c102e7f0db0d0
ToxValDB Uterotrophic Hershberger DB LEL =5 mg/day Mouse injection short-term; 14 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713357_15713363_15713367:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60d0338333c1da444aa3fae919abd985
ToxValDB Uterotrophic Hershberger DB LEL =6 mg/day Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713359_15713370:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9e7fe150dc9d27959542091055f0b297
ToxValDB Uterotrophic Hershberger DB LEL =0.0025 mg/kg bw/day Rat injection short-term; 7 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713409_15713524:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4915b738822e0727db98cc58d8337f4f
ToxValDB Uterotrophic Hershberger DB LEL =1 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713459_15713480_15713494_15713509_15713523_15713532_15713549_15713555_15713983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_176e56d5a0a844a1b53b5834316d960d
ToxValDB Uterotrophic Hershberger DB LEL =2.5 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713459_15713480_15713494_15713509_15713523_15713532_15713549_15713555_15713983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_edfe44b08b825db0e1203660df7d145f
ToxValDB Uterotrophic Hershberger DB LEL =5 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713459_15713480_15713494_15713509_15713523_15713532_15713549_15713555_15713983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_55cf8f72e8374d4388adf631831c6cea
ToxValDB Uterotrophic Hershberger DB LEL =10 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0 |::| 1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713459_15713480_15713494_15713509_15713523_15713532_15713549_15713555_15713983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d64cb6a75fdff5e68796834139379592
ToxValDB Uterotrophic Hershberger DB LEL =15 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713459_15713480_15713494_15713509_15713523_15713532_15713549_15713555_15713983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ebcb7f51b41c0259e650f2ae77b7b969
ToxValDB Uterotrophic Hershberger DB LEL =20 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713459_15713480_15713494_15713509_15713523_15713532_15713549_15713555_15713983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1467dcc9c5353d8aeaac79ee8fa90c0
ToxValDB Uterotrophic Hershberger DB LEL =25 mg/kg bw/day Mouse injection short-term; 28 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713548:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_820d53c8b3928dafa3623aca0d4b8f6c
ToxValDB Uterotrophic Hershberger DB LEL =30 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713459_15713480_15713494_15713509_15713523_15713532_15713549_15713555_15713983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_75444e7cb6f88068ef30790f3428ee80
ToxValDB Uterotrophic Hershberger DB LEL =35 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0 |::| 1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713459_15713480_15713494_15713509_15713523_15713532_15713549_15713555_15713983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c474e5d636776b16da5c9dfca245ed8f
ToxValDB Uterotrophic Hershberger DB LEL =50 mg/kg bw/day Rat oral short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713265_15713463_15713534_15713575_15713579_15713610:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58a73199077536859d98d60cb0a4e254
ToxValDB Uterotrophic Hershberger DB LEL =60 mg/kg bw/day Rat oral short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713265_15713463_15713534_15713575_15713579_15713610:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa8adb46bc9e0f9596b88db72325294f
ToxValDB Uterotrophic Hershberger DB LEL =125 mg/kg bw/day Rat oral short-term; 30 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713621:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c56c0722e211ab176726c5dfd83f391
ToxValDB Uterotrophic Hershberger DB LEL =200 mg/kg bw/day Mouse oral short-term; 7 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713650:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_888c23ee1d3078e2c4796f2a46bd12c2
ToxValDB Uterotrophic Hershberger DB LEL =250 mg/kg bw/day Rat injection short-term; 14 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713655:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c1f2f923d75962cc4ea142c6af282526
ToxValDB Uterotrophic Hershberger DB LEL =0.00027024 mg Mouse injection acute; 0.17 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713695:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f55d0467f3acb308ff4365187f5a20d0
ToxValDB Uterotrophic Hershberger DB LEL =0.4 mg Rat injection acute; 1 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713778:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9ca13a9196f3327673dfbf3881796c07
ToxValDB Uterotrophic Hershberger DB LEL =0.8 mg Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713780:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1239d8a561d7b6d33ae7e952c455c5b3
ToxValDB Uterotrophic Hershberger DB LEL =0.5 mg/day Mouse injection short-term; 10 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713895:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_073273dc259ed7ffbe71f5c989703717
ToxValDB Uterotrophic Hershberger DB LEL =375 mg/kg bw/day Rat oral short-term; 5 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713902:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_601656b99a9880b1f69baf3a68868f9d
ToxValDB Uterotrophic Hershberger DB LEL =0.02 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713459_15713480_15713494_15713509_15713523_15713532_15713549_15713555_15713983:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_256d6d030adf5a9b87e8ec84558badb0
Regulatory source 32 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 4 mg/kg bw/day - oral 2 weeks - p.32
Regulatory source - 4 mg/kg bw/day rat - - - p.69
Regulatory source - =5 - rat - 30 days - p.153
Regulatory source - 7.4 mg/kg bw human oral - - p.70
Regulatory source - 15 mg/kg bw - oral - - p.119
Regulatory source - 20 - - - - - p.119
Regulatory source - 25 % human oral - - p.70
Regulatory source - =35 mg/kg rat - 30 days - p.153
Regulatory source - =35 mg/kg rat - 12 months - p.153
Regulatory source - 40 mg/kg/day - - - - p.32
Regulatory source - 40 mg/kg/day rat - 12 weeks - p.60
Regulatory source - 40 mg/kg/day rat - 52 weeks - p.60
Regulatory source - =100 % rat oral 90-day - p.72
Regulatory source - 100 ppm rat - - - p.119
Regulatory source - 119 - - - - - p.119
Regulatory source - 1250 ppm - oral - - p.119
Regulatory source carcinogenicity 16 mg/kg bw/d pig oral Chronic carcinogenicity p.28
Regulatory source developmental toxicity 2000 mg/kg bw/day rat - developmental developmental toxicity p.37
Regulatory source repeated dose toxicity 100 mg/kg bw/d pig oral 28-day repeated dose toxicity p.27
Regulatory source repeated dose toxicity 100 mg/kg bw/d rat oral 28-day repeated dose toxicity p.74
Regulatory source reproductive toxicity 0.02 % rat oral developmental reproductive toxicity p.71
Regulatory source reproductive toxicity 0.3 % rat - developmental reproductive toxicity p.37
Regulatory source reproductive toxicity 5 mg/kg bw/d human - - reproductive toxicity p.37
Regulatory source reproductive toxicity 5 mg/kg bw/d rat - - reproductive toxicity p.38
Regulatory source reproductive toxicity 5 mg/kg rat oral - reproductive toxicity p.71
Regulatory source reproductive toxicity 5 mg/kg rat oral developmental reproductive toxicity p.71
Regulatory source reproductive toxicity 5 ppm rat oral Developmental reproductive toxicity p.119
Regulatory source reproductive toxicity 19 mg/kg bw/d rat oral - reproductive toxicity p.34
Regulatory source reproductive toxicity 19 mg/kg bw/d rat - - reproductive toxicity p.38
Regulatory source reproductive toxicity 35 mg/kg rat - 3 months reproductive toxicity p.67
Regulatory source reproductive toxicity 50 mg/kg/day - - 13 weeks reproductive toxicity p.60
Regulatory source reproductive toxicity 100 ppm rat oral developmental reproductive toxicity p.37
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier DH2M523P0H UNII - - - chemical -