Ginsenoside Rg1

INCI: GINSENOSIDE RG1

CAS Number
22427-39-0
Function
Skin conditioning, antioxidant (major protopanaxatriol-type ginsenoside)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not prohibited or restricted under 21 CFR; covered under CIR Panax spp. assessment (safe as used, 2015)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

High variability in content across Panax species (320โ€“58,400 ppm in root); neurostimulatory properties documented orally โ€” unlikely to be relevant at cosmetic dermal doses; estrogenic activity in vitro

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Concern Level: Low

Frequently Asked Questions

Is Ginsenoside Rg1 safe in cosmetics?

High variability in content across Panax species (320โ€“58,400 ppm in root); neurostimulatory properties documented orally โ€” unlikely to be relevant at cosmetic dermal doses; estrogenic activity in vitro The EU classifies Ginsenoside Rg1 as "permitted". Safety rating: GOOD.

Is Ginsenoside Rg1 allowed in the EU?

Ginsenoside Rg1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ginsenoside Rg1 do in cosmetics?

Ginsenoside Rg1 functions as: Skin conditioning, antioxidant (major protopanaxatriol-type ginsenoside). It is classified as a cosmetic ingredient in our database. CAS number: 22427-39-0.

What is the Margin of Safety for Ginsenoside Rg1?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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