Ginsenoside Rg4

INCI: GINSENOSIDE RG4

CAS Number
126223-28-7
Function
Skin conditioning (antioxidant, anti-inflammatory constituent of ginseng saponins)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not specifically prohibited or restricted under 21 CFR Parts 700โ€“740; CIR concluded Panax spp. root-derived ingredients safe as used (2012)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Minor ginsenoside formed during steaming/processing of red/black ginseng; limited standalone toxicological data but oral bioavailability of related ginsenosides is very low.

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Concern Level: Moderate

Frequently Asked Questions

Is Ginsenoside Rg4 safe in cosmetics?

Minor ginsenoside formed during steaming/processing of red/black ginseng; limited standalone toxicological data but oral bioavailability of related ginsenosides is very low. The EU classifies Ginsenoside Rg4 as "permitted". Safety rating: MODERATE.

Is Ginsenoside Rg4 allowed in the EU?

Ginsenoside Rg4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ginsenoside Rg4 do in cosmetics?

Ginsenoside Rg4 functions as: Skin conditioning (antioxidant, anti-inflammatory constituent of ginseng saponins). It is classified as a cosmetic ingredient in our database. CAS number: 126223-28-7.

What is the Margin of Safety for Ginsenoside Rg4?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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