Is Ginsenoside Rg4 safe in cosmetics?
Ginsenoside Rg4 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Ginsenoside Rg4
INCI: GINSENOSIDE RG4
Ginsenoside Rg4 (CAS 126223-28-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning (antioxidant, anti-inflammatory constituent of ginseng. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 126223-28-7 →
Function
Skin conditioning (antioxidant, anti-inflammatory constituent of ginseng saponins)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2Z)-6-methylhepta-2,5-dien-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol
InChIKey
QOMBXPYXWGTFNR-KRPFXEAISA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not specifically prohibited or restricted under 21 CFR Parts 700–740; CIR concluded Panax spp. root-derived ingredients safe as used (2012)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ginsenoside Rg4.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Editorial summary
Preliminary editorial summary for Ginsenoside Rg4 — not a computed safety verdict. See the sourced toxicological data above.
Chemical Function
Antioxidant
Frequently Asked Questions
Is Ginsenoside Rg4 allowed in the EU?
Ginsenoside Rg4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ginsenoside Rg4 do in cosmetics?
Ginsenoside Rg4 functions as: Skin conditioning (antioxidant, anti-inflammatory constituent of ginseng saponins). It is classified as a cosmetic ingredient in our database. CAS number: 126223-28-7.
Compliance Tools
Check Ginsenoside Rg4 compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Fragrance ingredient
GINKGO BILOBA NUT/GLYCYRRHIZA URALENSIS ROOT/LEONURUS JAPONICUS/PSILOTUM NUDUM/PINUS KORAIENSIS LEAF FERMENT EXTRACT
GOOD
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GINSENOSIDES
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Skin Conditioning
GLASS
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Abrasive, Opacifying
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