Moderate Cosmetic Ingredient

Glucosamine Salicylate

INCI: GLUCOSAMINE SALICYLATE

CAS Number
Not widely published (salt of glucosamine + salicylic acid)
Function
Skin conditioning, keratolytic (combines glucosamine skin-conditioning with salicylate exfoliation)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
EU Max Conc. 2.0%
🇺🇸 US Status permitted
US Notes Permitted as cosmetic ingredient; salicylic acid at certain concentrations is regulated as an OTC drug active (21 CFR 333 for acne, 21 CFR 358 for dandruff); cosmetic use at low levels is permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Salicylate content must be calculated and declared against Annex III limits; prohibited for children under 3 years except in shampoos; aspirin cross-reactivity risk exists; equivalent salicylic acid concentration released from the salt must be verified analytically; systemic toxicity risk if Annex III limits are exceeded

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Concern Level: High

Frequently Asked Questions

Is Glucosamine Salicylate safe in cosmetics?

Salicylate content must be calculated and declared against Annex III limits; prohibited for children under 3 years except in shampoos; aspirin cross-reactivity risk exists; equivalent salicylic acid concentration released from the salt must be verified analytically; systemic toxicity risk if Annex III limits are exceeded The EU classifies Glucosamine Salicylate as "restricted". Safety rating: MODERATE.

Is Glucosamine Salicylate allowed in the EU?

Glucosamine Salicylate EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does Glucosamine Salicylate do in cosmetics?

Glucosamine Salicylate functions as: Skin conditioning, keratolytic (combines glucosamine skin-conditioning with salicylate exfoliation). It is classified as a cosmetic ingredient in our database. CAS number: Not widely published (salt of glucosamine + salicylic acid).

What is the Margin of Safety for Glucosamine Salicylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Glucosamine Salicylate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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