Glucosamine Thioctate

INCI: GLUCOSAMINE THIOCTATE

CAS Number
Not widely published (salt of glucosamine + thioctic acid / alpha-lipoic acid)
Function
Skin conditioning, antioxidant. Combines glucosamine HA synthesis with alpha-lipoic acid's potent antioxidant and anti-glycation activity.
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR; alpha-lipoic acid is also used as a dietary supplement.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Alpha-lipoic acid is susceptible to oxidation and polymerization, requiring nitrogen blanketing, amber packaging, and antioxidant co-stabilizers. Isolated allergic contact dermatitis case reports for alpha-lipoic acid warrant patch testing in sensitization-prone populations. Shellfish-source allergen concern exists for glucosamine moiety.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Glucosamine Thioctate safe in cosmetics?

Alpha-lipoic acid is susceptible to oxidation and polymerization, requiring nitrogen blanketing, amber packaging, and antioxidant co-stabilizers. Isolated allergic contact dermatitis case reports for alpha-lipoic acid warrant patch testing in sensitization-prone populations. Shellfish-source allergen concern exists for glucosamine moiety. The EU classifies Glucosamine Thioctate as "permitted". Safety rating: GOOD.

Is Glucosamine Thioctate allowed in the EU?

Glucosamine Thioctate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glucosamine Thioctate do in cosmetics?

Glucosamine Thioctate functions as: Skin conditioning, antioxidant. Combines glucosamine HA synthesis with alpha-lipoic acid's potent antioxidant and anti-glycation activity.. It is classified as a cosmetic ingredient in our database. CAS number: Not widely published (salt of glucosamine + thioctic acid / alpha-lipoic acid).

What is the Margin of Safety for Glucosamine Thioctate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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