NOAEL Studies Humectant

Glycerin NOAEL Studies

INCI: GLYCERIN

CAS: 56-81-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =15 g/kg rat oral 42 days repeated dose toxicity (1; 3; 42, p.6
CIR Safety Assessment NOAEL =53.4 % rat oral 4 weeks repeated dose toxicity 6; 30; 20, p.6
CIR Safety Assessment NOAEL =10 mg/kg rat oral 1 month repeated dose toxicity 22; 1,000; 1, p.6
CIR Safety Assessment NOAEL =115 mg/ kg rat oral 44 days oral toxicity 4,30; 32; 115, p.8
CIR Safety Assessment NOAEL =950 mg/kg/d rat oral 44 days oral toxicity 2,300; 44; 33, p.8
CIR Safety Assessment NOAEL =2.2 g/kg/d rat oral 50-week inhalation toxicity 50; 80; 30, p.8
CIR Safety Assessment NOAEL >99.8 % rat inhalation 5 d inhalation toxicity (1; 10, 13; 18, 16, p.10
CIR Safety Assessment NOAEL =1 mg/kg/d rat oral - developmental toxicity 10; (9; 0, p.11
CIR Safety Assessment NOAEL =2200 mg/kg/d rat oral 3 days developmental toxicity 3; 3,800; 36, p.15
CIR Safety Assessment NOAEL =1000 mg/m3 rat oral 40 days developmental toxicity 6,300; 30; 40, p.15
CIR Safety Assessment NOAEL =1310 mg/kg/d rat oral 45 weeks developmental toxicity 0; 100; 30, p.15
CIR Safety Assessment NOAEL =1280 mg/kg/d rat oral 45 weeks developmental toxicity 30; 45; 1,000, p.15
CIR Safety Assessment NOAEL =1180 mg/kg/d rat oral 5 d developmental toxicity 1,000; 6; 5, p.15
COSMOS DB 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 1000 mg/kg bw/day dog oral 120 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1180 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1250 mg/kg bw/day dog oral 728 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1280 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1310 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2000 mg/kg bw/day rat oral 44 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 4000 mg/kg bw/day guinea pig oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5000 mg/kg bw/day rabbit oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 6000 mg/kg bw/day rabbit oral NA Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 9000 mg/kg bw/day dog oral 350 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 10000 mg/kg bw/day rat oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 12500 mg/kg bw/day mouse oral 56 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 15000 mg/kg bw/day rat oral NA Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 20000 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
WHO/JECFA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA ADI =20 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v48je16; title=ALIPHATIC ACYCLIC DIOLS, TRIOLS, AND RELATED SUBSTANCES (JECFA Food Additives Series 48); path=mirror/documents/jecfa/jecmono/v48je16.htm; row_hash=5a89a7544a8055e3; raw_unit=mg/kg bw; context=925) was considered at the seventh meeting, when an ADI of 0–20 mg/kg bw was established (Annex 1, reference 7 ); it was further considered at the seventeenth meeting, when the ADI was increased to 0–25 mg/kg bw (Annex 1, reference 32 ).
WHO/JECFA ADI =25 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v48je16; title=ALIPHATIC ACYCLIC DIOLS, TRIOLS, AND RELATED SUBSTANCES (JECFA Food Additives Series 48); path=mirror/documents/jecfa/jecmono/v48je16.htm; row_hash=98fcf558c1278b91; raw_unit=mg/kg bw; context=925) was considered at the seventh meeting, when an ADI of 0–20 mg/kg bw was established (Annex 1, reference 7 ); it was further considered at the seventeenth meeting, when the ADI was increased to 0–25 mg/kg bw (Annex 1, reference 32 ).
WHO/JECFA NOEL =1300 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v48je16; title=ALIPHATIC ACYCLIC DIOLS, TRIOLS, AND RELATED SUBSTANCES (JECFA Food Additives Series 48); path=mirror/documents/jecfa/jecmono/v48je16.htm; row_hash=71cb182bb575bc97; raw_unit=mg/kg bw per day; context=The NOEL was 1300 mg/kg bw per day (Gaunt et al., 1972).
WHO/JECFA NOEL =5000 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v48je16; title=ALIPHATIC ACYCLIC DIOLS, TRIOLS, AND RELATED SUBSTANCES (JECFA Food Additives Series 48); path=mirror/documents/jecfa/jecmono/v48je16.htm; row_hash=6bd162aed83dd918; raw_unit=mg/kg bw per day; context=The NOEL was 5% glycerol in the diet, equivalent to 5000 mg/kg bw per day (Guerrant et al., 1947).
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >0.57 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5017; Record_ID=acute_inhalation_3002; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.57; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE acute oral 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =5570 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7712; row=15335; data_type=In Vivo; mixture=Chemical; chemical_name=Glycerol; preferred_name=Glycerol; dtxsid=DTXSID9020663; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020663; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =12600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7714; row=15333; data_type=In Vivo; mixture=Chemical; chemical_name=Glycerol; preferred_name=Glycerol; dtxsid=DTXSID9020663; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020663; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =15890 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_7716; row=15332; data_type=In Vivo; mixture=Chemical; chemical_name=Glycerol; preferred_name=Glycerol; dtxsid=DTXSID9020663; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020663; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >18315 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_7718; row=15331; data_type=In Vivo; mixture=Chemical; chemical_name=Glycerol; preferred_name=Glycerol; dtxsid=DTXSID9020663; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020663; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 <21980 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_7719; row=15330; data_type=In Vivo; mixture=Chemical; chemical_name=Glycerol; preferred_name=Glycerol; dtxsid=DTXSID9020663; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020663; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =25000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_7720; row=15329; data_type=In Vivo; mixture=Chemical; chemical_name=Glycerol; preferred_name=Glycerol; dtxsid=DTXSID9020663; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020663; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =27200 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_7721; row=15336; data_type=In Vivo; mixture=Chemical; chemical_name=Glycerol; preferred_name=Glycerol; dtxsid=DTXSID9020663; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020663; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =27500 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_7723; row=15328; data_type=In Vivo; mixture=Chemical; chemical_name=Glycerol; preferred_name=Glycerol; dtxsid=DTXSID9020663; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020663; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =27650 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_7725; row=15334; data_type=In Vivo; mixture=Chemical; chemical_name=Glycerol; preferred_name=Glycerol; dtxsid=DTXSID9020663; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020663; source_file=acute_oral.xlsx
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10008; RecordID=ARPathway2016_1335; DatasetName=ARPathway2016; DTXSID=DTXSID9020663; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE eye irritation 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation Draize rabbit irritation score 1.7 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2738; Record_ID=eye_irritation_140; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=1.7; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE eye irritation EPA Classification 4 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2736; Record_ID=eye_irritation_140; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE eye irritation Intensity 0.34 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2740; Record_ID=eye_irritation_1218; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=Vitrigel; Endpoint=Intensity; Response=0.34; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE eye irritation Lag time 0 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2737; Record_ID=eye_irritation_1218; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE eye irritation Plateau level 20.4 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2742; Record_ID=eye_irritation_1218; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=Vitrigel; Endpoint=Plateau level; Response=20.40; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation Viability 67.97 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5784; Record_ID=skin_irritation_invitro_913; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=67.97; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 85.5 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5785; Record_ID=skin_irritation_invitro_914; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=85.5; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 89.73 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5790; Record_ID=skin_irritation_invitro_924; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=89.73; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 94 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5793; Record_ID=skin_irritation_invitro_930; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=94; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 96 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5787; Record_ID=skin_irritation_invitro_918; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=96; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 97.23 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5788; Record_ID=skin_irritation_invitro_920; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=97.23; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 98.06 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5796; Record_ID=skin_irritation_invitro_936; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=98.06; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 98.16 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5794; Record_ID=skin_irritation_invitro_932; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=98.16; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 98.48 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5802; Record_ID=skin_irritation_invitro_948; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=98.48; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 99.04 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5797; Record_ID=skin_irritation_invitro_938; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=99.04; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 99.41 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5799; Record_ID=skin_irritation_invitro_942; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=99.41; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 100.58 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5786; Record_ID=skin_irritation_invitro_916; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=100.58; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 101.24 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5800; Record_ID=skin_irritation_invitro_944; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=101.24; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 101.35 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5791; Record_ID=skin_irritation_invitro_926; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=101.35; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 101.75 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5798; Record_ID=skin_irritation_invitro_940; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=101.75; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 103.3 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5792; Record_ID=skin_irritation_invitro_928; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=103.3; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 103.6 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5795; Record_ID=skin_irritation_invitro_934; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=103.6; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 103.63 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5803; Record_ID=skin_irritation_invitro_950; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=103.63; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 104.17 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5804; Record_ID=skin_irritation_invitro_952; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=104.17; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin irritation Viability 104.84 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5801; Record_ID=skin_irritation_invitro_946; Data_Type=In Vitro; Formulation_Name=Glycerol; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=104.84; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization 52 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD86, EC150 >200 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8711; Record_ID=skin_sensitization_invitro_2413; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization CD86, EC150 >644.658 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8149; Record_ID=skin_sensitization_invitro_2172; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=92.094; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=644.658; Converted_Response_Unit=ug/mL; Response=644.658; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization CV75 833.3 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2717; Record_ID=skin_sensitization_invitro_642; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=h-CLAT; Endpoint=CV75; Reported_Response=833.3; Reported_Response_Unit=ug/mL; Response=833.3; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization CV75 >5000 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2244; Record_ID=skin_sensitization_invitro_551; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=h-CLAT; Endpoint=CV75; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=5000; Reported_Response_Unit=ug/mL; Response=5000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Cys -3.8 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=582; Record_ID=skin_sensitization_invitro_169; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-3.8; Reported_Response_Unit=%; Response=-3.8; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Cys -1.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1076; Record_ID=skin_sensitization_invitro_293; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-1.1000000000000001; Reported_Response_Unit=%; Response=-1.1; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Cys -0.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=588; Record_ID=skin_sensitization_invitro_170; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-0.7; Reported_Response_Unit=%; Response=-0.7; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Cys 1.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=599; Record_ID=skin_sensitization_invitro_173; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=1.2; Reported_Response_Unit=%; Response=1.2; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Cys 1.8 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1068; Record_ID=skin_sensitization_invitro_290; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=1.8; Reported_Response_Unit=%; Response=1.8; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Cys 2.5 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=595; Record_ID=skin_sensitization_invitro_172; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=2.5; Reported_Response_Unit=%; Response=2.5; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys -4.8 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1074; Record_ID=skin_sensitization_invitro_293; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-4.8; Reported_Response_Unit=%; Response=-4.8; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys 0 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=598; Record_ID=skin_sensitization_invitro_173; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys 0.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1064; Record_ID=skin_sensitization_invitro_290; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.1; Reported_Response_Unit=%; Response=0.1; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys 0.8 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=593; Record_ID=skin_sensitization_invitro_172; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.8; Reported_Response_Unit=%; Response=0.8; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys 1.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=587; Record_ID=skin_sensitization_invitro_170; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.3; Reported_Response_Unit=%; Response=1.3; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys 2.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=580; Record_ID=skin_sensitization_invitro_169; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.1; Reported_Response_Unit=%; Response=2.1; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys + Cys 0.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=589; Record_ID=skin_sensitization_invitro_170; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.3; Reported_Response_Unit=%; Response=0.3; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys + Cys 0.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=600; Record_ID=skin_sensitization_invitro_173; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.6; Reported_Response_Unit=%; Response=0.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys + Cys 0.95 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1070; Record_ID=skin_sensitization_invitro_290; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.95; Reported_Response_Unit=%; Response=0.95; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys + Cys 1.05 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=584; Record_ID=skin_sensitization_invitro_169; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.05; Reported_Response_Unit=%; Response=1.05; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Depletion Lys + Cys 1.65 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=596; Record_ID=skin_sensitization_invitro_172; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.65; Reported_Response_Unit=%; Response=1.65; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization EC1.5 1793.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6046; Record_ID=skin_sensitization_invitro_1436; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1793.9; Reported_Response_Unit=uM; Response=1793.9; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization EC1.5 >2000 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6040; Record_ID=skin_sensitization_invitro_1423; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response=No induction; Reported_Response_Unit=Unitless; Conversion_Factor=Text to numeric; Conversion_Factor_Value=No induction assumed >2000 uM; Conversion_Factor_Source=Manually calculated; Converted_Response_Modifier=>; Converted_Response=2000; Converted_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization IC50 >2400 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7628; Record_ID=skin_sensitization_invitro_1796; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2400; Reported_Response_Unit=uM; Response=2400; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.024 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6225; Record_ID=skin_sensitization_invitro_1428; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.024; Reported_Response_Unit=Unitless; Response=1.024; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.032 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6227; Record_ID=skin_sensitization_invitro_1431; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.032; Reported_Response_Unit=Unitless; Response=1.032; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.1 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6229; Record_ID=skin_sensitization_invitro_1441; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1000000000000001; Reported_Response_Unit=Unitless; Response=1.1; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.12 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6231; Record_ID=skin_sensitization_invitro_1433; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1200000000000001; Reported_Response_Unit=Unitless; Response=1.12; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.127 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6233; Record_ID=skin_sensitization_invitro_1434; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.127; Reported_Response_Unit=Unitless; Response=1.127; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.13 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6235; Record_ID=skin_sensitization_invitro_1416; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1299999999999999; Reported_Response_Unit=Unitless; Response=1.13; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.134 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6056; Record_ID=skin_sensitization_invitro_1425; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1339999999999999; Reported_Response_Unit=Unitless; Response=1.134; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.146 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6057; Record_ID=skin_sensitization_invitro_1420; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1459999999999999; Reported_Response_Unit=Unitless; Response=1.146; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.156 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7525; Record_ID=skin_sensitization_invitro_1796; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=LuSens; Endpoint=Imax; Reported_Response=1.155674771; Reported_Response_Unit=Unitless; Response=1.156; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.16 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6058; Record_ID=skin_sensitization_invitro_1430; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1599999999999999; Reported_Response_Unit=Unitless; Response=1.16; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.162 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6059; Record_ID=skin_sensitization_invitro_1423; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1619999999999999; Reported_Response_Unit=Unitless; Response=1.162; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.17 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6060; Record_ID=skin_sensitization_invitro_1442; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.17; Reported_Response_Unit=Unitless; Response=1.17; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.193 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6061; Record_ID=skin_sensitization_invitro_1435; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1930000000000001; Reported_Response_Unit=Unitless; Response=1.193; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.2 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6062; Record_ID=skin_sensitization_invitro_1414; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2; Reported_Response_Unit=Unitless; Response=1.2; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.208 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6065; Record_ID=skin_sensitization_invitro_1432; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.208; Reported_Response_Unit=Unitless; Response=1.208; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.212 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6066; Record_ID=skin_sensitization_invitro_1422; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.212; Reported_Response_Unit=Unitless; Response=1.212; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.216 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6067; Record_ID=skin_sensitization_invitro_1417; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.216; Reported_Response_Unit=Unitless; Response=1.216; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.217 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6068; Record_ID=skin_sensitization_invitro_1421; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2170000000000001; Reported_Response_Unit=Unitless; Response=1.217; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.22 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6069; Record_ID=skin_sensitization_invitro_1418; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.22; Reported_Response_Unit=Unitless; Response=1.22; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.238 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6070; Record_ID=skin_sensitization_invitro_1419; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.238; Reported_Response_Unit=Unitless; Response=1.238; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.269 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6071; Record_ID=skin_sensitization_invitro_1429; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2689999999999999; Reported_Response_Unit=Unitless; Response=1.269; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.3 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6072; Record_ID=skin_sensitization_invitro_1439; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.3; Reported_Response_Unit=Unitless; Response=1.3; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.353 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6073; Record_ID=skin_sensitization_invitro_1427; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.353; Reported_Response_Unit=Unitless; Response=1.353; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.4 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6074; Record_ID=skin_sensitization_invitro_1437; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4; Reported_Response_Unit=Unitless; Response=1.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.568 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6075; Record_ID=skin_sensitization_invitro_1426; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.5680000000000001; Reported_Response_Unit=Unitless; Response=1.568; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Imax 1.634 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6076; Record_ID=skin_sensitization_invitro_1436; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.6339999999999999; Reported_Response_Unit=Unitless; Response=1.634; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=8212; Record_ID=skin_sensitization_invivo_1856; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Ryan et al. 2000; 10945748; 10.1034/j.1600-0536.2000.043002095.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
NTP ICE skin sensitization Relative reliability score 5 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=8216; Record_ID=skin_sensitization_invivo_1856; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID9020663; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=5; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Ryan et al. 2000; 10945748; 10.1034/j.1600-0536.2000.043002095.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020663; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020663
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =1180 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be1e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13661/7/9/3?documentUUID=36fabf14-e66d-449e-8e83-0eb6fc266aeb; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15823644:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f3806a861ee71b6d8d10307a42a420fb
ECHA NOAEL =1280 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd210; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/14285?documentUUID=61f7aee5-57e9-47bb-84b8-5dc8cd600c5d; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15824658:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d99f88ed71930726f40e033978f1f367
ECHA NOAEL =1310 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd21a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/14285?documentUUID=61f7aee5-57e9-47bb-84b8-5dc8cd600c5d; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15824660:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_58661f545af5edebb0eccaa8c2fefe34
Regulatory source 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 1 mg/kg/d rat oral - developmental toxicity p.11
Regulatory source developmental toxicity 1 mg/kg/d mouse oral - developmental toxicity p.11
Regulatory source developmental toxicity 2200 mg/kg/d rat oral 3 days developmental toxicity p.15
Regulatory source developmental toxicity 1000 mg/m3 rat oral 40 days developmental toxicity p.15
Regulatory source developmental toxicity 1310 mg/kg/d rat oral 45 weeks developmental toxicity p.15
Regulatory source developmental toxicity 1280 mg/kg/d rat oral 45 weeks developmental toxicity p.15
Regulatory source developmental toxicity 1180 mg/kg/d rat oral 5 d developmental toxicity p.15
Regulatory source inhalation toxicity 2.2 g/kg/d rat oral 50-week inhalation toxicity p.8
Regulatory source inhalation toxicity >99.8 % rat inhalation 5 d inhalation toxicity p.10
Regulatory source oral toxicity 115 mg/ kg rat oral 44 days oral toxicity p.8
Regulatory source oral toxicity 950 mg/kg/d rat oral 44 days oral toxicity p.8
Regulatory source repeated dose toxicity 15 g/kg rat oral 42 days repeated dose toxicity p.6
Regulatory source repeated dose toxicity 53.4 % rat oral 4 weeks repeated dose toxicity p.6
Regulatory source repeated dose toxicity 10 mg/kg rat oral 1 month repeated dose toxicity p.6
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier PDC6A3C0OX UNII - - - chemical -