Glyceryl Glycyrrhetinate

INCI: GLYCERYL GLYCYRRHETINATE

CAS Number
108916-85-4
Function
Emulsifier, skin conditioning (anti-inflammatory via glycyrrhetinic acid moiety)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” licorice and licorice derivatives are FDA GRAS; CIR Expert Panel concluded glycyrrhetinic acid and its salts/esters are safe for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Glycyrrhetinic acid exhibits cytotoxicity and pseudohyperaldosteronism at high systemic doses, but these effects are not relevant at cosmetic dermal-use concentrations.

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Concern Level: Low

Frequently Asked Questions

Is Glyceryl Glycyrrhetinate safe in cosmetics?

Glycyrrhetinic acid exhibits cytotoxicity and pseudohyperaldosteronism at high systemic doses, but these effects are not relevant at cosmetic dermal-use concentrations. The EU classifies Glyceryl Glycyrrhetinate as "permitted". Safety rating: GOOD.

Is Glyceryl Glycyrrhetinate allowed in the EU?

Glyceryl Glycyrrhetinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glyceryl Glycyrrhetinate do in cosmetics?

Glyceryl Glycyrrhetinate functions as: Emulsifier, skin conditioning (anti-inflammatory via glycyrrhetinic acid moiety). It is classified as a cosmetic ingredient in our database. CAS number: 108916-85-4.

What is the Margin of Safety for Glyceryl Glycyrrhetinate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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