Glycol Ethylhexanoate

INCI: GLYCOL ETHYLHEXANOATE

CAS Number
Not confirmed (structurally: ethylene glycol mono-2-ethylhexanoate)
Function
Emollient, skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

2-Ethylhexanoic acid is a known reproductive toxicant (Repr. Cat. 2, H361d) at systemic doses โ€” relevant if significant hydrolysis and absorption occur. Must demonstrate negligible systemic exposure for CPSR adequacy. Ethylene glycol moiety adds theoretical concern for nephrotoxicity at impossible cosmetic exposure levels.

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Concern Level: Moderate

Frequently Asked Questions

Is Glycol Ethylhexanoate safe in cosmetics?

2-Ethylhexanoic acid is a known reproductive toxicant (Repr. Cat. 2, H361d) at systemic doses โ€” relevant if significant hydrolysis and absorption occur. Must demonstrate negligible systemic exposure for CPSR adequacy. Ethylene glycol moiety adds theoretical concern for nephrotoxicity at impossible cosmetic exposure levels. The EU classifies Glycol Ethylhexanoate as "permitted". Safety rating: MODERATE.

Is Glycol Ethylhexanoate allowed in the EU?

Glycol Ethylhexanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glycol Ethylhexanoate do in cosmetics?

Glycol Ethylhexanoate functions as: Emollient, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not confirmed (structurally: ethylene glycol mono-2-ethylhexanoate).

What is the Margin of Safety for Glycol Ethylhexanoate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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