Poor Cosmetic Ingredient

Granulocyte Colony-Stimulating Factor (G-CSF)

INCI: NOT ASSIGNED

CAS Number
143011-72-7 (recombinant human G-CSF / Filgrastim)
Function
Claimed skin regeneration, wound healing stimulation (primarily pharmaceutical, not cosmetic)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status restricted
US Notes Drug classification. FDA considers growth factors like G-CSF as drug substances when claims of biological activity are made. Not listed in PCPC INCI dictionary for cosmetic use. Any product containing G-CSF making regenerative claims would be regulated as a drug.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CRITICAL: Do not use in cosmetic products. Falls under pharmaceutical regulation. Using G-CSF in cosmetics risks product reclassification as a medicinal product, regulatory enforcement, and serious safety liability. Not COSMOS/ECOCERT eligible.

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Concern Level: High

Frequently Asked Questions

Is Granulocyte Colony-Stimulating Factor (G-CSF) safe in cosmetics?

CRITICAL: Do not use in cosmetic products. Falls under pharmaceutical regulation. Using G-CSF in cosmetics risks product reclassification as a medicinal product, regulatory enforcement, and serious safety liability. Not COSMOS/ECOCERT eligible. The EU classifies Granulocyte Colony-Stimulating Factor (G-CSF) as "prohibited". Safety rating: POOR.

Is Granulocyte Colony-Stimulating Factor (G-CSF) allowed in the EU?

Granulocyte Colony-Stimulating Factor (G-CSF) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Granulocyte Colony-Stimulating Factor (G-CSF) do in cosmetics?

Granulocyte Colony-Stimulating Factor (G-CSF) functions as: Claimed skin regeneration, wound healing stimulation (primarily pharmaceutical, not cosmetic). It is classified as a cosmetic ingredient in our database. CAS number: 143011-72-7 (recombinant human G-CSF / Filgrastim).

What is the Margin of Safety for Granulocyte Colony-Stimulating Factor (G-CSF)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Granulocyte Colony-Stimulating Factor (G-CSF) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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