Gynostemma Pentaphyllum Leaf/Stem Extract

INCI: GYNOSTEMMA PENTAPHYLLUM LEAF/STEM EXTRACT

CAS Number
Not specifically assigned (gypenoside-rich extract; general species extract may cite 223748-39-8)
Function
Astringent, antioxidant, hair conditioning, skin conditioning emollient
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not prohibited or restricted under 21 CFR Parts 250, 700; botanical ingredient under general cosmetic provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Botanical extract containing gypenosides (saponins) with antioxidant and conditioning properties; may cause mild irritation at high concentrations; no genotoxicity reported; recommended use level 0.5โ€“2%.

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Concern Level: Low

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Gynostemma Pentaphyllum Leaf/Stem Extract safe in cosmetics?

Botanical extract containing gypenosides (saponins) with antioxidant and conditioning properties; may cause mild irritation at high concentrations; no genotoxicity reported; recommended use level 0.5โ€“2%. The EU classifies Gynostemma Pentaphyllum Leaf/Stem Extract as "permitted". Safety rating: GOOD.

Is Gynostemma Pentaphyllum Leaf/Stem Extract allowed in the EU?

Gynostemma Pentaphyllum Leaf/Stem Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Gynostemma Pentaphyllum Leaf/Stem Extract do in cosmetics?

Gynostemma Pentaphyllum Leaf/Stem Extract functions as: Astringent, antioxidant, hair conditioning, skin conditioning emollient. It is classified as a cosmetic ingredient in our database. CAS number: Not specifically assigned (gypenoside-rich extract; general species extract may cite 223748-39-8).

What is the Margin of Safety for Gynostemma Pentaphyllum Leaf/Stem Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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