NOAEL Studies Cosmetic Ingredient

HC Blue No. 12 NOAEL Studies

INCI: HC BLUE NO. 12

CAS: 132885-85-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =30 mg/kg bw rat oral 90-day irritation p.5
SCCS Opinion NOAEL =140 mg/kg bw rat dermal 90-day dermal absorption p.5
SCCS Opinion NOAEL =316 mg/kg bw/d - - 28 day NOAEL study p.18
SCCS Opinion NOAEL =60 mg/kg bw/d rat oral 13 weeks NOAEL study p.19
SCCS Opinion NOAEL =140 mg/kg bw/d human - developmental developmental toxicity p.27
SCCS Opinion NOAEL =0.253 mg/kg rat oral 13-week dermal absorption p.29
SCCS Opinion NOAEL =60 mg/kg bw rat oral 13-week dermal absorption p.29
SCCS Opinion NOAEL =1668 mg/kg bw rat - 28 day repeated dose toxicity p.29
Regulatory source 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 316 mg/kg bw/d - - 28 day - p.18
Regulatory source - 60 mg/kg bw/d rat oral 13 weeks - p.19
Regulatory source dermal absorption 140 mg/kg bw rat dermal 90-day dermal absorption p.5
Regulatory source dermal absorption =0.253 mg/kg rat oral 13-week dermal absorption p.29
Regulatory source dermal absorption =60 mg/kg bw rat oral 13-week dermal absorption p.29
Regulatory source developmental toxicity 140 mg/kg bw/d human - developmental developmental toxicity p.27
Regulatory source irritation 30 mg/kg bw rat oral 90-day irritation p.5
Regulatory source repeated dose toxicity 60 mg/kg bw/d - - sub-chronic repeated dose toxicity p.20
Regulatory source repeated dose toxicity 1668 mg/kg bw rat - 28 day repeated dose toxicity p.29
Regulatory source repeated dose toxicity 60 mg/kg bw/d rat - 28 day repeated dose toxicity p.29
Regulatory source repeated dose toxicity 140 mg/kg bw/d rat - 28 day repeated dose toxicity p.29
Regulatory source repeated dose toxicity 1668 mg/kg bw rat dermal 28 day repeated dose toxicity p.29
Regulatory source repeated dose toxicity 60 mg/kg bw/d rat dermal 28 day repeated dose toxicity p.29
Regulatory source repeated dose toxicity 140 mg/kg bw/d rat dermal 28 day repeated dose toxicity p.29