NOAEL Studies Cosmetic Ingredient

HC Blue No. 15 NOAEL Studies

INCI: HC BLUE NO. 15

CAS: 74578-10-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 4 mg/kg bw/day rat oral 90 day Subchronic SCCS; scientific report
COSMOS DB NOAEL 1 mg/kg bw/day rat oral 90 day Subchronic SCCS; scientific report
SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =4 mg/kg bw/day - - Chronic genotoxicity p.16
SCCS Opinion NOAEL =3 mg/kg bw/day rat - - dermal absorption p.22
SCCS Opinion NOAEL =4 mg/kg bw - oral 28 d NOAEL study p.23
SCCS Opinion NOAEL =0.02 mg/kg bw/d rat oral 90 day dermal absorption p.25
SCCS Opinion NOAEL =4 mg/kg bw/d rat oral 90 day dermal absorption p.25
SCCS Opinion NOAEL =1.76 μg/cm - oral sub-chronic repeated dose toxicity p.25
SCCS Opinion NOAEL =0.0003 mg/kg bw/d rat oral 90 day dermal absorption p.29
Regulatory source 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 4 mg/kg bw - oral 28 d - p.23
Regulatory source dermal absorption 3 mg/kg bw/day rat - - dermal absorption p.22
Regulatory source dermal absorption =0.02 mg/kg bw/d rat oral 90 day dermal absorption p.25
Regulatory source dermal absorption =4 mg/kg bw/d rat oral 90 day dermal absorption p.25
Regulatory source dermal absorption =0.0003 mg/kg bw/d rat oral 90 day dermal absorption p.29
Regulatory source genotoxicity 4 mg/kg bw/day - - Chronic genotoxicity p.16
Regulatory source repeated dose toxicity 1.76 μg/cm - oral sub-chronic repeated dose toxicity p.25
Regulatory source repeated dose toxicity 4 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.25
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 62LA9436UJ UNII - - - chemical -