NOAEL Studies Cosmetic Ingredient

HC Orange No. 2 NOAEL Studies

INCI: HC ORANGE NO. 2

CAS: 85765-48-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 5 mg/kg bw/day rat oral 6-19 Gestation day Developmental SCCP; G. Chevalier. HC Orange N°2 (B067): Prenatal Developmental Toxicity Study by OralRoute (Gavage) in Rats. CIT Study No. 26898 RSR, 2005
SCCS Opinion 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =150 mg/kg/day rat oral 90 day dermal absorption p.5
SCCS Opinion NOAEL =500 mg/kg/day - - Chronic genotoxicity p.16
SCCS Opinion NOAEL =100 mg/kg/day rat oral developmental developmental toxicity p.21
SCCS Opinion NOAEL =20 mg/kg/day - - - NOAEL study p.21
SCCS Opinion NOAEL =0.016 mg/kg rat oral - dermal absorption p.22
SCCS Opinion NOAEL =20 mg/kg bw rat oral - dermal absorption p.22
SCCS Opinion NOAEL =150 mg/kg bw - - 90-day NOAEL study p.22
SCCS Opinion NOAEL =100 mg/kg bw/day - - 90-day NOAEL study p.22
SCCS Opinion NOAEL =500 mg/kg bw/day rabbit - developmental developmental toxicity p.23
Regulatory source 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 20 mg/kg/day - - - - p.21
Regulatory source - 500 mg/kg/day - - - - p.21
Regulatory source - 150 mg/kg bw - - 90-day - p.22
Regulatory source - 100 mg/kg bw/day - - 90-day - p.22
Regulatory source dermal absorption 150 mg/kg/day rat oral 90 day dermal absorption p.5
Regulatory source dermal absorption =0.016 mg/kg rat oral - dermal absorption p.22
Regulatory source dermal absorption =20 mg/kg bw rat oral - dermal absorption p.22
Regulatory source developmental toxicity 100 mg/kg/day rat oral developmental developmental toxicity p.21
Regulatory source developmental toxicity 20 mg/kg/day rabbit - developmental developmental toxicity p.23
Regulatory source developmental toxicity 500 mg/kg bw/day rabbit - developmental developmental toxicity p.23
Regulatory source developmental toxicity 100 mg/kg bw/day rabbit - developmental developmental toxicity p.23
Regulatory source genotoxicity 500 mg/kg/day - - Chronic genotoxicity p.16
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 86WS98470U UNII - - - chemical -