NOAEL Studies Cosmetic Ingredient

HC Orange No. 3 NOAEL Studies

INCI: HC ORANGE NO. 3

CAS: 81612-54-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 91 day Subchronic SCCNFP; Toxicol Labs Ltd, UK. Report No. LRL/34/94 (March 1995)
SCCNFP Opinion 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =100 mg/kg bw/day rat - subchronic repeated dose toxicity p.7
SCCNFP Opinion NOAEL =300 mg/kg bw/day rat - subchronic repeated dose toxicity p.7
Regulatory source 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source repeated dose toxicity 100 mg/kg bw/day rat - subchronic repeated dose toxicity p.7
Regulatory source repeated dose toxicity 300 mg/kg bw/day rat - subchronic repeated dose toxicity p.7
Regulatory source sensitisation 100 mg/kg bw/day rat oral 13-week sensitisation p.15
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 428754S94Z UNII - - - chemical -