NOAEL Studies Cosmetic Ingredient

Heptanal NOAEL Studies

CAS: 111-71-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL 3500 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=945cc522-249f-459b-904e-4ddc37e31878.i6z; document=2e7a719b-3b01-42dc-b239-be7bab5c381d_945cc522-249f-459b-904e-4ddc37e31878.i6d; document_key=2e7a719b-3b01-42dc-b239-be7bab5c381d/945cc522-249f-459b-904e-4ddc37e31878; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-29; basis=other:; key_result=false; entry_uuid=a22d6404-4251-48b3-a1b8-b333cc155c5b
ECHA NOAEL <=200 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=945cc522-249f-459b-904e-4ddc37e31878.i6z; document=69402ae4-be8b-4efc-b69c-1906ee98a421_945cc522-249f-459b-904e-4ddc37e31878.i6d; document_key=69402ae4-be8b-4efc-b69c-1906ee98a421/945cc522-249f-459b-904e-4ddc37e31878; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-06-14; basis=other:; key_result=false; upper_value=200; entry_uuid=ee472164-d0cf-41f3-9b86-336c3c093191
ECHA NOAEL 1000 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=945cc522-249f-459b-904e-4ddc37e31878.i6z; document=69402ae4-be8b-4efc-b69c-1906ee98a421_945cc522-249f-459b-904e-4ddc37e31878.i6d; document_key=69402ae4-be8b-4efc-b69c-1906ee98a421/945cc522-249f-459b-904e-4ddc37e31878; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-06-14; basis=other:; key_result=false; entry_uuid=6d26669d-468b-40de-a36f-71440b2ab138
ECHA NOAEL 300 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=945cc522-249f-459b-904e-4ddc37e31878.i6z; document=04fbbffc-6b1f-494b-876e-4402f7d3c707_945cc522-249f-459b-904e-4ddc37e31878.i6d; document_key=04fbbffc-6b1f-494b-876e-4402f7d3c707/945cc522-249f-459b-904e-4ddc37e31878; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-04-23; basis=other:; key_result=false; entry_uuid=76b11a3a-7fa0-443d-99cd-a7a0d448752a
ECHA NOAEL 1750 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=945cc522-249f-459b-904e-4ddc37e31878.i6z; document=2e7a719b-3b01-42dc-b239-be7bab5c381d_945cc522-249f-459b-904e-4ddc37e31878.i6d; document_key=2e7a719b-3b01-42dc-b239-be7bab5c381d/945cc522-249f-459b-904e-4ddc37e31878; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-29; basis=other:; key_result=false; entry_uuid=c6646cae-b26c-4c2f-8cd5-dc2edb29b0d8
ECHA NOAEL =1000 mg/kg bw/day Rat oral short-term; 2 weeks short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d2204ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34385/7/6/2?documentUUID=945cc522-249f-459b-904e-4ddc37e31878; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850420:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4461e4c350fb3bd2339c885f93b90ca6
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >18.4 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=182; Record_ID=acute_inhalation_2597; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=18.4; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE acute oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =14000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1057; row=532; data_type=In Vivo; mixture=Chemical; chemical_name=Heptanal; preferred_name=Heptanal; dtxsid=DTXSID0021597; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1056; row=533; data_type=In Vivo; mixture=Chemical; chemical_name=Heptanal; preferred_name=Heptanal; dtxsid=DTXSID0021597; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021597; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =3200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1055; row=534; data_type=In Vivo; mixture=Chemical; chemical_name=Heptanal; preferred_name=Heptanal; dtxsid=DTXSID0021597; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021597; source_file=acute_oral.xlsx
NTP ICE endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 19.8348560906589 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10180; RecordID=ERPathway2016_303; DatasetName=ERPathway2016; DTXSID=DTXSID0021597; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=19.8348560906589; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE endocrine ACC 73.6087999579639 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10181; RecordID=ERPathway2016_303; DatasetName=ERPathway2016; DTXSID=DTXSID0021597; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=73.6087999579639; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10176; RecordID=ARPathway2016_576; DatasetName=ARPathway2016; DTXSID=DTXSID0021597; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE endocrine Model Score 0.0319 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=10182; RecordID=ERPathway2016_303; DatasetName=ERPathway2016; DTXSID=DTXSID0021597; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0319; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation 39 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation ET50 125 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=188; Record_ID=skin_irritation_invitro_1438; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=125; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 20.2 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=189; Record_ID=skin_irritation_invitro_1436; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=20.2; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 16.2 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=190; Record_ID=skin_irritation_invitro_1434; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=16.2; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 16.1 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=191; Record_ID=skin_irritation_invitro_1431; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=16.1; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 13.8 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=192; Record_ID=skin_irritation_invitro_1427; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=13.8; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 8.3 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=193; Record_ID=skin_irritation_invitro_1424; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=8.3; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 8.1 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=194; Record_ID=skin_irritation_invitro_1423; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=8.1; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 7.3 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=195; Record_ID=skin_irritation_invitro_1420; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=7.3; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 6.5 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=196; Record_ID=skin_irritation_invitro_1418; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=6.5; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 4.5 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=197; Record_ID=skin_irritation_invitro_1416; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=4.5; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation ET50 4.2 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=199; Record_ID=skin_irritation_invitro_1414; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=ET50; Response=4.2; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Positive reaction 58.6 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=101; Record_ID=skin_irritation_invivo_12; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=58.6; Response_Unit=%; Species=Human; Reference=Jirova et al. 2010; 20136894; 10.1111/j.1600-0536.2009.01640.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 29.44 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=200; Record_ID=skin_irritation_invitro_330; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=29.44; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 14.2 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=201; Record_ID=skin_irritation_invitro_373; Data_Type=In Vitro; Formulation_Name=Heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=Viability; Response=14.2; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 7.1 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=202; Record_ID=skin_irritation_invitro_372; Data_Type=In Vitro; Formulation_Name=Heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=Viability; Response=7.1; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 5.4 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=203; Record_ID=skin_irritation_invitro_371; Data_Type=In Vitro; Formulation_Name=Heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=Viability; Response=5.4; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 20.4 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=204; Record_ID=skin_irritation_invitro_369; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=20.40; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 19.2 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=205; Record_ID=skin_irritation_invitro_368; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=19.2; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 14.9 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=206; Record_ID=skin_irritation_invitro_366; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=14.9; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 13.3 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=207; Record_ID=skin_irritation_invitro_364; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=13.3; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 10 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=208; Record_ID=skin_irritation_invitro_362; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=10; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 8.2 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=209; Record_ID=skin_irritation_invitro_358; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=8.20; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 19.9 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=210; Record_ID=skin_irritation_invitro_357; Data_Type=In Vitro; Formulation_Name=Heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=19.90; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 18.2 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=211; Record_ID=skin_irritation_invitro_355; Data_Type=In Vitro; Formulation_Name=Heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=18.2; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 13.7 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=212; Record_ID=skin_irritation_invitro_352; Data_Type=In Vitro; Formulation_Name=Heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=13.7; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 25 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=214; Record_ID=skin_irritation_invitro_351; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=25; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 9.8 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=215; Record_ID=skin_irritation_invitro_341; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=9.80; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 8.1 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=216; Record_ID=skin_irritation_invitro_339; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=8.1; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 12.8 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=217; Record_ID=skin_irritation_invitro_338; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=Viability; Response=12.8; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 10.4 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=218; Record_ID=skin_irritation_invitro_335; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=Viability; Response=10.4; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 9.1 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=219; Record_ID=skin_irritation_invitro_333; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiDerm Irritation; Endpoint=Viability; Response=9.1; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 6.49 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=223; Record_ID=skin_irritation_invitro_322; Data_Type=In Vitro; Formulation_Name=Heptanal; Concentration=95; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=EpiSkin Irritation; Endpoint=Viability; Response=6.49; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 8 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=224; Record_ID=skin_irritation_invitro_323; Data_Type=In Vitro; Formulation_Name=heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=8; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 8.4 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=226; Record_ID=skin_irritation_invitro_325; Data_Type=In Vitro; Formulation_Name=heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=8.4; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 8.6 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=227; Record_ID=skin_irritation_invitro_326; Data_Type=In Vitro; Formulation_Name=heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=8.6; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 14 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=228; Record_ID=skin_irritation_invitro_327; Data_Type=In Vitro; Formulation_Name=heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=14; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability 23.3 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=230; Record_ID=skin_irritation_invitro_329; Data_Type=In Vitro; Formulation_Name=heptanal; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=23.3; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability (18 hours) 9.7 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=247; Record_ID=skin_irritation_invitro_214; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=9.7; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin irritation Viability (42 hours) 6.6 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=221; Record_ID=skin_irritation_invitro_214; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=6.6; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3659; Record_ID=skin_sensitization_invivo_910; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90183-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3657; Record_ID=skin_sensitization_invivo_910; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90183-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3663; Record_ID=skin_sensitization_invivo_910; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021597; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90183-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021597; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021597
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =98.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632437:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_811d442c14f65781ab9df711079e8b69
ToxValDB HPVIS 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HPVIS LOAEL =150 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=Gaunt, I.F., G. Wright, R. Cottrell and S. D. Gangolli (1983) Short-term toxicity of 2,6-dimethylhept-5-en-1-al in rats. Journal of Food and Chemical Toxicology, 21(5): 543-549.; TITLE=Short-term toxicity of 2,6-dimethylhept-5-en-1-al in rats; AUTHOR=Gaunt, I.F., G. Wright, R. Cottrell and S. D. Gangolli; QUALITY=1; EXTERNAL_SOURCE_ID=62083; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT_CATEGORY=-|multiple; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639768_15639836:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6398a9462d820f9cfeaea1f47a3009d4
ToxValDB HPVIS NOAEL =500 mg/kg bw/day Rabbit dermal short-term; 2 weeks short-term LONG_REF=Auletta C. (1981) A 28-day toxicity study in rabbits. Project No.6510-80. Unpublished report to FFHPVC.; TITLE=A 28-day toxicity study in rabbits; AUTHOR=Auletta, C. S; QUALITY=2; EXTERNAL_SOURCE_ID=63919; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS:15639462:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_004c119705fdbadf85071ce746287d85
ToxValDB HPVIS NOAEL =37 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=Gaunt, I.F., G. Wright, R. Cottrell and S. D. Gangolli (1983) Short-term toxicity of 2,6-dimethylhept-5-en-1-al in rats. Journal of Food and Chemical Toxicology, 21(5): 543-549.; TITLE=Short-term toxicity of 2,6-dimethylhept-5-en-1-al in rats; AUTHOR=Gaunt, I.F., G. Wright, R. Cottrell and S. D. Gangolli; QUALITY=1; EXTERNAL_SOURCE_ID=61575; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639768_15639836:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_05c487342c27384b9f02bfb661e7cd21
ToxValDB HPVIS NOAEL =2050 mg/kg bw/day Rat oral - reproduction developmental LONG_REF=Carruthers C. and Stowall R.E. (1941) Influence of heptaldehyde on the pregnancy in rats. Cancer Research, 1(9):724-728.; TITLE=Influence of heptaldehyde on the pregnancy in rats; AUTHOR=Carruthers C. and Stowall R.E; QUALITY=3; EXTERNAL_SOURCE_ID=64428; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1941; ORIGINAL_YEAR=1941; STUDY_GROUP=HPVIS:15643019:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_478f06b0fe2980eea040cc664766087c
ToxValDB RSL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB RSL RfC =0.003 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15656631:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af259c39385ec39f47a8a0f2642efeaa
ToxValDB RSL RfC =0.03 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663488:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_59253affcad7eab4876573f09d98223c
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 92N104S3HF UNII - - - chemical -