Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
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Expert Verdict
No standalone CIR safety assessment. The palmitoyl derivative (Palmitoyl Heptapeptide-18) was included in a broader CIR scientific literature review of palmitoyl oligopeptides, which noted an absence of acute toxicity, repeated dose, genotoxicity, carcinogenicity, and reproductive toxicity data. Best known through its lipophilic derivative, Palmitoyl Heptapeptide-18, which acts as a "smart ligand" that binds neuronal cells and inhibits acetylcholine release, producing a Botox-like anti-wrinkl...
Frequently Asked Questions
Is Heptapeptide-18 safe in cosmetics?
No standalone CIR safety assessment. The palmitoyl derivative (Palmitoyl Heptapeptide-18) was included in a broader CIR scientific literature review of palmitoyl oligopeptides, which noted an absence of acute toxicity, repeated dose, genotoxicity, carcinogenicity, and reproductive toxicity data. Best known through its lipophilic derivative, Palmitoyl Heptapeptide-18, which acts as a "smart ligand" that binds neuronal cells and inhibits acetylcholine release, producing a Botox-like anti-wrinkl... The EU classifies Heptapeptide-18 as "prohibited". Safety rating: MODERATE.
Is Heptapeptide-18 allowed in the EU?
Heptapeptide-18 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Heptapeptide-18 do in cosmetics?
Heptapeptide-18 functions as: Skin conditioning (miscellaneous). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned in CosIng or major chemical databases.
What is the Margin of Safety for Heptapeptide-18?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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