Hexanediol Disalicylate

INCI: HEXANEDIOL DISALICYLATE

CAS Number
Not widely listed (ester of hexanediol + salicylic acid)
Function
Skin conditioning agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.5%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific 21 CFR restriction; salicylate-release must comply with OTC monograph if drug claims are made

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hydrolysis product (salicylic acid) is a regulated substance under EU Annex III; must quantify free salicylic acid release in finished product; note hexyl salicylate (a related substance) was recently classified CMR Cat. 2 (Repr.) and restricted to Annex III Entry 380 per EU 2026/78 โ€” verify no regulatory confusion; not for use in children's products due to salicylate restriction.

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Concern Level: Moderate

Frequently Asked Questions

Is Hexanediol Disalicylate safe in cosmetics?

Hydrolysis product (salicylic acid) is a regulated substance under EU Annex III; must quantify free salicylic acid release in finished product; note hexyl salicylate (a related substance) was recently classified CMR Cat. 2 (Repr.) and restricted to Annex III Entry 380 per EU 2026/78 โ€” verify no regulatory confusion; not for use in children's products due to salicylate restriction. The EU classifies Hexanediol Disalicylate as "restricted". Safety rating: MODERATE.

Is Hexanediol Disalicylate allowed in the EU?

Hexanediol Disalicylate EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexanediol Disalicylate do in cosmetics?

Hexanediol Disalicylate functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: Not widely listed (ester of hexanediol + salicylic acid).

What is the Margin of Safety for Hexanediol Disalicylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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