Regulatory Status
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Safety Data
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Expert Verdict
No formal CIR review; melanogenesis-stimulating activity requires caution in individuals with melanoma risk; amino acid sequence not specified in CosIng, with sequence ambiguity noted as a general peptide concern.
Frequently Asked Questions
Is Hexapeptide-1 safe in cosmetics?
No formal CIR review; melanogenesis-stimulating activity requires caution in individuals with melanoma risk; amino acid sequence not specified in CosIng, with sequence ambiguity noted as a general peptide concern. The EU classifies Hexapeptide-1 as "permitted". Safety rating: MODERATE.
Is Hexapeptide-1 allowed in the EU?
Hexapeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-1 do in cosmetics?
Hexapeptide-1 functions as: Skin Conditioning — α-MSH biomimetic peptide; promotes melanin transfer, photoprotection, tan acceleration. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned for base peptide (Acetyl Hexapeptide-1: CAS 448944-47-6).
What is the Margin of Safety for Hexapeptide-1?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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