Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
CIR conclusion applies only to Val-Gly-Val-Ala-Pro-Gly sequence; alternative sequence Ala-Pro-Gly-Val-Gly-Val under same INCI lacks coverage and sufficient data; moderate conjunctival irritation noted in rabbit eye study for palmitoyl derivative
Frequently Asked Questions
Is Hexapeptide-12 safe in cosmetics?
CIR conclusion applies only to Val-Gly-Val-Ala-Pro-Gly sequence; alternative sequence Ala-Pro-Gly-Val-Gly-Val under same INCI lacks coverage and sufficient data; moderate conjunctival irritation noted in rabbit eye study for palmitoyl derivative The EU classifies Hexapeptide-12 as "permitted". Safety rating: GOOD.
Is Hexapeptide-12 allowed in the EU?
Hexapeptide-12 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-12 do in cosmetics?
Hexapeptide-12 functions as: Skin Conditioning — elastin-derived peptide with defined sequence Val-Gly-Val-Ala-Pro-Gly. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned for base peptide (Palmitoyl Hexapeptide-12 has supplier-specific identifiers).
What is the Margin of Safety for Hexapeptide-12?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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