Hexapeptide-26

INCI: HEXAPEPTIDE-26

CAS Number
Not publicly assigned for the bare peptide (Palmitoyl Hexapeptide-26 is the more commonly referenced acylated form)
Function
The acylated derivative (Palmitoyl Hexapeptide-26) is classified as an antimicrobial agent in CosIng
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically prohibited or restricted; generally allowed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No completed CIR safety review; antimicrobial function of acylated form warrants careful evaluation for skin microbiome impact. The palmitoyl derivative notably functions as an antimicrobial agent rather than just a skin conditioner, distinguishing it from most other peptides in this list

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Concern Level: Moderate

Frequently Asked Questions

Is Hexapeptide-26 safe in cosmetics?

No completed CIR safety review; antimicrobial function of acylated form warrants careful evaluation for skin microbiome impact. The palmitoyl derivative notably functions as an antimicrobial agent rather than just a skin conditioner, distinguishing it from most other peptides in this list The EU classifies Hexapeptide-26 as "permitted". Safety rating: MODERATE.

Is Hexapeptide-26 allowed in the EU?

Hexapeptide-26 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexapeptide-26 do in cosmetics?

Hexapeptide-26 functions as: The acylated derivative (Palmitoyl Hexapeptide-26) is classified as an antimicrobial agent in CosIng. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned for the bare peptide (Palmitoyl Hexapeptide-26 is the more commonly referenced acylated form).

What is the Margin of Safety for Hexapeptide-26?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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