Is Hexapeptide-37 safe in cosmetics?
Hexapeptide-37 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexapeptide-37
INCI: HEXAPEPTIDE-37
Hexapeptide-37 (CAS Not assigned independently; acetylated form (Acetyl Hexapeptide-37) = 1447824-16-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning — enhances Aquaporin-3 expression, improves transepidermal. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
Not assigned independently; acetylated form (Acetyl Hexapeptide-37) = 1447824-16-9
View industrial chemical safety profile →
Function
Skin conditioning — enhances Aquaporin-3 expression, improves transepidermal water flux and barrier function
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not listed as prohibited or restricted in 21 CFR; no CIR monograph exists.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-37.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-37.
Frequently Asked Questions
Is Hexapeptide-37 allowed in the EU?
Hexapeptide-37 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-37 do in cosmetics?
Hexapeptide-37 functions as: Skin conditioning — enhances Aquaporin-3 expression, improves transepidermal water flux and barrier function. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned independently; acetylated form (Acetyl Hexapeptide-37) = 1447824-16-9.
Compliance Tools
Check Hexapeptide-37 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Is Hexapeptide-37 in Your Products?
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