Hexapeptide-37

INCI: HEXAPEPTIDE-37

CAS Number
Not assigned independently; acetylated form (Acetyl Hexapeptide-37) = 1447824-16-9
Function
Skin conditioning — enhances Aquaporin-3 expression, improves transepidermal water flux and barrier function
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — not listed as prohibited or restricted in 21 CFR; no CIR monograph exists.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No CIR review available. Safety assessment relies on read-across from Acetyl Hexapeptide-8 class and supplier-generated safety data.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Hexapeptide-37 safe in cosmetics?

No CIR review available. Safety assessment relies on read-across from Acetyl Hexapeptide-8 class and supplier-generated safety data. The EU classifies Hexapeptide-37 as "permitted". Safety rating: MODERATE.

Is Hexapeptide-37 allowed in the EU?

Hexapeptide-37 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexapeptide-37 do in cosmetics?

Hexapeptide-37 functions as: Skin conditioning — enhances Aquaporin-3 expression, improves transepidermal water flux and barrier function. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned independently; acetylated form (Acetyl Hexapeptide-37) = 1447824-16-9.

What is the Margin of Safety for Hexapeptide-37?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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