NOAEL Studies Cosmetic Ingredient

Hexyl Propionate NOAEL Studies

INCI: HEXYL PROPIONATE

CAS: 2445-76-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_4467; row=9422; data_type=In Vivo; mixture=Chemical; chemical_name=Hexyl propanoate; preferred_name=Hexyl propanoate; dtxsid=DTXSID5047582; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5047582; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=6271; Record_ID=skin_sensitization_invivo_1438; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5047582; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1988; Not available; 10.1016/0278-6915(88)90178-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5047582
NTP_ICE_skin_sensitization Induction dose per skin area 8100 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=6325; Record_ID=skin_sensitization_invivo_1438; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5047582; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=8100; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1988; Not available; 10.1016/0278-6915(88)90178-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5047582
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=6275; Record_ID=skin_sensitization_invivo_1438; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5047582; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1988; Not available; 10.1016/0278-6915(88)90178-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5047582
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=75 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b79b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27349?documentUUID=33c27743-6611-4d65-a574-2dd42dd09b17; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855036_15856645:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e248e0bc6b0d3a80eb7e9e7508932f4
ToxValDB_ECHA_IUCLID NOAEL =15 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b79b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27349?documentUUID=33c27743-6611-4d65-a574-2dd42dd09b17; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855036_15856645:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e1f65a9e2b042a2057daf386ced24fbe
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8R2W3UA8JV UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8R2W3UA8JV"}
openFDA substances FDA UNII substance identifier 8R2W3UA8JV UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8R2W3UA8JV"}
openFDA substances FDA UNII substance identifier 8R2W3UA8JV UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8R2W3UA8JV"}
openFDA substances FDA UNII substance identifier 8R2W3UA8JV UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8R2W3UA8JV"}