NOAEL Studies Cosmetic Ingredient

Histidine NOAEL Studies

CAS: 71-00-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 7 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 382.92 mg/kg bw/day - - - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=961c746f-92a5-469f-b208-8eea50caf418_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=961c746f-92a5-469f-b208-8eea50caf418/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; basis=body weight and weight gain; key_result=false; entry_uuid=8133f0b4-16b4-48f5-996f-b756f3c7b8b1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 452.19 mg/kg bw/day - - - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=961c746f-92a5-469f-b208-8eea50caf418_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=961c746f-92a5-469f-b208-8eea50caf418/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; basis=body weight and weight gain; key_result=false; entry_uuid=ed5f30b1-62bb-4dcf-b80e-eb7609f6f80c
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 382.92 mg/kg bw/day - - - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=961c746f-92a5-469f-b208-8eea50caf418_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=961c746f-92a5-469f-b208-8eea50caf418/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; basis=body weight and weight gain; key_result=false; entry_uuid=8133f0b4-16b4-48f5-996f-b756f3c7b8b1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 452.19 mg/kg bw/day - - - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=961c746f-92a5-469f-b208-8eea50caf418_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=961c746f-92a5-469f-b208-8eea50caf418/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; basis=body weight and weight gain; key_result=false; entry_uuid=ed5f30b1-62bb-4dcf-b80e-eb7609f6f80c
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 382.92 mg/kg bw/day - - - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=961c746f-92a5-469f-b208-8eea50caf418_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=961c746f-92a5-469f-b208-8eea50caf418/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; basis=body weight and weight gain; key_result=false; entry_uuid=8133f0b4-16b4-48f5-996f-b756f3c7b8b1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 452.19 mg/kg bw/day - - - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=961c746f-92a5-469f-b208-8eea50caf418_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=961c746f-92a5-469f-b208-8eea50caf418/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; basis=body weight and weight gain; key_result=false; entry_uuid=ed5f30b1-62bb-4dcf-b80e-eb7609f6f80c
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 472.9 mg/kg bw/day rat oral: feed - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=3ec05c6f-935c-4e5d-bbff-4f768a203313_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=3ec05c6f-935c-4e5d-bbff-4f768a203313/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=body weight and weight gain; key_result=false; entry_uuid=0305cf3b-e156-4b1a-8267-15f7f3f0555a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 558.45 mg/kg bw/day rat oral: feed - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=3ec05c6f-935c-4e5d-bbff-4f768a203313_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=3ec05c6f-935c-4e5d-bbff-4f768a203313/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=body weight and weight gain; key_result=false; entry_uuid=6054f7d0-f49e-4685-8df3-081ea90332e1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 472.9 mg/kg bw/day rat oral: feed - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=3ec05c6f-935c-4e5d-bbff-4f768a203313_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=3ec05c6f-935c-4e5d-bbff-4f768a203313/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=body weight and weight gain; key_result=false; entry_uuid=0305cf3b-e156-4b1a-8267-15f7f3f0555a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 558.45 mg/kg bw/day rat oral: feed - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=3ec05c6f-935c-4e5d-bbff-4f768a203313_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=3ec05c6f-935c-4e5d-bbff-4f768a203313/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=body weight and weight gain; key_result=false; entry_uuid=6054f7d0-f49e-4685-8df3-081ea90332e1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 472.9 mg/kg bw/day rat oral: feed - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=3ec05c6f-935c-4e5d-bbff-4f768a203313_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=3ec05c6f-935c-4e5d-bbff-4f768a203313/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=body weight and weight gain; key_result=false; entry_uuid=0305cf3b-e156-4b1a-8267-15f7f3f0555a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 558.45 mg/kg bw/day rat oral: feed - chronic toxicity: oral dossier=f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6z; document=3ec05c6f-935c-4e5d-bbff-4f768a203313_f4f7b546-54cf-4d28-bf1b-bd246cf6bb17.i6d; document_key=3ec05c6f-935c-4e5d-bbff-4f768a203313/f4f7b546-54cf-4d28-bf1b-bd246cf6bb17; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=body weight and weight gain; key_result=false; entry_uuid=6054f7d0-f49e-4685-8df3-081ea90332e1
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >15000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9571; row=15530; data_type=In Vivo; mixture=Chemical; chemical_name=Histidine; preferred_name=L-Histidine; dtxsid=DTXSID9023126; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9023126; source_file=acute_oral.xlsx
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =83.38 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632564:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_427518329866ce0cf204df7a365ad8fd
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 4QD397987E UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H9N3O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4QD397987E"}
openFDA substances FDA UNII substance identifier 4QD397987E UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H9N3O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4QD397987E"}
openFDA substances FDA UNII substance identifier 4QD397987E UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H9N3O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4QD397987E"}
openFDA substances FDA UNII substance identifier 4QD397987E UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H9N3O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4QD397987E"}