Horseradish Peroxidase

INCI: HORSERADISH PEROXIDASE

CAS Number
9003-99-0
Function
Skin conditioning; enzyme-catalyzed antioxidant and detoxifier
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted and not specifically restricted under 21 CFR; no CIR monograph exists

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Reactive catalytic enzyme requiring H2O2 co-substrate with potential for uncontrolled oxidative reactions in poorly formulated products; potential immunogenic response in sensitive skin.

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Concern Level: Moderate

Regulatory Flags

eu_children_restricted

Frequently Asked Questions

Is Horseradish Peroxidase safe in cosmetics?

Reactive catalytic enzyme requiring H2O2 co-substrate with potential for uncontrolled oxidative reactions in poorly formulated products; potential immunogenic response in sensitive skin. The EU classifies Horseradish Peroxidase as "permitted". Safety rating: MODERATE.

Is Horseradish Peroxidase allowed in the EU?

Horseradish Peroxidase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Horseradish Peroxidase do in cosmetics?

Horseradish Peroxidase functions as: Skin conditioning; enzyme-catalyzed antioxidant and detoxifier. It is classified as a cosmetic ingredient in our database. CAS number: 9003-99-0.

What is the Margin of Safety for Horseradish Peroxidase?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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