NOAEL Studies
Cosmetic Ingredient
Hydrogen Peroxide NOAEL Studies
INCI: HYDROGEN PEROXIDE
CAS: 7722-84-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 300 | ppm | mouse | oral | 90 day | Subchronic | PAFA; study report |
| COSMOS DB | NOAEL | 60 | mg/kg bw/day | rat | oral | 100 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | ppm | mouse | oral | 90 day | Subchronic | PAFA; study report |
| COSMOS DB | NOAEL | 150 | mg/kg bw/day | rat | oral | 245 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 250 | mg/kg bw/day | mouse | oral | 756 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 450 | mg/kg bw/day | rat | oral | 21 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 153 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | mouse | oral | 180 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2500 | mg/kg bw/day | rat | oral | 146 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =100 | mg/kg | Mouse | oral: drinking water | 90 days | subchronic | EFSA CEF - 2013 - OutputID 2206 - food consumption - systemic - Scientific Opinion on the safety evaluation of the active substances, sodium carbonate peroxyhydrate coated with sodium carbonate and sodium silicate, bentonite, sodium chloride, sodium carbonate for use in active food contact materials. - doi:10.2903/j.efsa.2013.3153 |
| EFSA | NOAEL | =100 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA CEF (2013). Scientific Opinion on the safety evaluation of the active substances, sodium carbonate peroxyhydrate coated with sodium carbonate and sodium silicate, bentonite, sodium chloride, sodium carbonate for use in active food contact materials. doi:10.2903/j.efsa.2013.3153.; TITLE=Scientific Opinion on the safety evaluation of the active substances, sodium carbonate peroxyhydrate coated with sodium carbonate and sodium silicate, bentonite, sodium chloride, sodium carbonate for use in active food contact materials.; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2013.3153; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=EFSA:15614451:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c34a529f6308812813c796f45f97255f |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | - |
NTP ICE acute dermal 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=659; Record_ID=acute_dermal_559; Data_Type=In Vivo; Formulation_ID=MIX552; Formulation_Name=Ygiene 206; Percent_Active_Ingredient=5.6; Mixture=Mixture; DTXSID=DTXSID2020715; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=660; Record_ID=acute_dermal_559; Data_Type=In Vivo; Formulation_ID=MIX552; Formulation_Name=Ygiene 206; Percent_Active_Ingredient=5.6; Mixture=Mixture; DTXSID=DTXSID2020715; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715 |
| NTP ICE acute dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=658; Record_ID=acute_dermal_559; Data_Type=In Vivo; Formulation_ID=MIX552; Formulation_Name=Ygiene 206; Percent_Active_Ingredient=5.6; Mixture=Mixture; DTXSID=DTXSID2020715; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715 |
NTP ICE acute inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | GHS Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1334; Record_ID=acute_inhalation_458; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX552; Formulation_Name=Ygiene 206; Percent_Active_Ingredient=5.6; Mixture=Mixture; DTXSID=DTXSID2020715; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715 |
| NTP ICE acute inhalation | LC50 | 2.15 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1337; Record_ID=acute_inhalation_458; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX552; Formulation_Name=Ygiene 206; Percent_Active_Ingredient=5.6; Mixture=Mixture; DTXSID=DTXSID2020715; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.15; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715 |
| NTP ICE acute inhalation | LC50 | 2 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1335; Record_ID=acute_inhalation_2774; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2020715; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715 |
NTP ICE acute oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13220; row=3815; data_type=In Vivo; mixture=Mixture; formulation_id=MIX697; formulation_name=Greenclean 6% Liquid; chemical_name=Hydrogen peroxide; preferred_name=Hydrogen peroxide; percent_active_ingredient=5.34; dtxsid=DTXSID2020715; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13142; row=3819; data_type=In Vivo; mixture=Mixture; formulation_id=MIX552; formulation_name=Ygiene 206; chemical_name=Hydrogen Peroxide; preferred_name=Hydrogen peroxide; percent_active_ingredient=5.6; dtxsid=DTXSID2020715; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13220; row=3816; data_type=In Vivo; mixture=Mixture; formulation_id=MIX697; formulation_name=Greenclean 6% Liquid; chemical_name=Hydrogen peroxide; preferred_name=Hydrogen peroxide; percent_active_ingredient=5.34; dtxsid=DTXSID2020715; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13142; row=3817; data_type=In Vivo; mixture=Mixture; formulation_id=MIX552; formulation_name=Ygiene 206; chemical_name=Hydrogen Peroxide; preferred_name=Hydrogen peroxide; percent_active_ingredient=5.6; dtxsid=DTXSID2020715; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3129 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13142; row=3818; data_type=In Vivo; mixture=Mixture; formulation_id=MIX552; formulation_name=Ygiene 206; chemical_name=Hydrogen Peroxide; preferred_name=Hydrogen peroxide; percent_active_ingredient=5.6; dtxsid=DTXSID2020715; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715; source_file=acute_oral.xlsx |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=2448; Record_ID=cancer_3924; Data_Type=WOE; Formulation_Name=Hydrogen peroxide; Mixture=Chemical; DTXSID=DTXSID2020715; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/54; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=738; Record_ID=eye_irritation_1205; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID1059; Formulation_Name=Ygiene 206; Percent_Active_Ingredient=5.6; Mixture=Mixture; DTXSID=DTXSID2020715; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715 |
NTP ICE skin irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | EPA classification | 3 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=518; Record_ID=skin_irritation_invivo_666; Data_Type=In Vivo; Formulation_ID=MIX552; Formulation_Name=Ygiene 206; Percent_Active_Ingredient=5.6; Mixture=Mixture; DTXSID=DTXSID2020715; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020715 |
SCCNFP Opinion 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =30 | mg/kg/day | rat | oral | 6 days | NOAEL study | p.11 |
| SCCNFP Opinion | NOAEL | =30 | mg/kg bw/day | rat | oral | - | repeated dose toxicity | p.30 |
| SCCNFP Opinion | NOAEL | =56.2 | mg/kg/day | rat | oral | 6 weeks | NOAEL study | p.11 |
| SCCNFP Opinion | NOAEL | =100 | ppm | rat | oral | 2 weeks | NOAEL study | p.11 |
SCCS Opinion 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.15 | % | mouse | oral | Sub-chronic | repeated dose toxicity | p.19 |
| SCCS Opinion | NOAEL | =5 | % | mouse | oral | 25 weeks | carcinogenicity | p.34 |
| SCCS Opinion | NOAEL | =20 | mg/kg bw/day | rat | oral | 100 days | NOAEL study | p.20 |
| SCCS Opinion | NOAEL | =30 | mg/kg/day | rat | oral | 6 days | NOAEL study | p.11 |
| SCCS Opinion | NOAEL | =56.2 | mg/kg/day | rat | oral | 6 weeks | NOAEL study | p.11 |
| SCCS Opinion | NOAEL | =56.2 | mg/kg/day | rat | oral | 6 days | NOAEL study | p.20 |
| SCCS Opinion | NOAEL | =86 | mg/kg bw/day | rat | - | - | NOAEL study | p.20 |
| SCCS Opinion | NOAEL | =100 | ppm | rat | oral | 2 weeks | NOAEL study | p.11 |
| SCCS Opinion | NOAEL | =100 | ppm | rat | oral | 6 days | NOAEL study | p.20 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/d | - | - | - | NOAEL study | p.92 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/d | rabbit | dermal | 6 days | NOAEL study | p.90 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/d | - | oral | 8 days | NOAEL study | p.90 |
| SCCS Opinion | NOAEL | =1129 | - | human | oral | developmental | reproductive toxicity | p.93 |
ECHA 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =50 | mg/kg bw/day | Rat | injection | - | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c78e4b096bca8772185; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/3/5?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID:15815453:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_719d7178e31c6e840123e84eea436f19 |
| ECHA | LEL | =170 | mg/m3 | Rat | inhalation | - | acute | GUIDELINE=OECD Guideline 403 (Acute Inhalation Toxicity); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/3/3?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID:15798639:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c7c773a5ca1a6f49c1b1b0edc82538f |
| ECHA | LEL | =2000 | mg/m3 | Rat | inhalation | - | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/3/3?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID:15798260:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_201ccccf64bcbffec9710cd8cab9ae98 |
| ECHA | LOAEL | =0.005 | mg/kg bw/day | Rat | oral | chronic; 6 months | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c62039e4b096bca878081b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/6/5?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID:15852188:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee5841a3d358e6e080294b637a3bd939 |
| ECHA | LOAEL | =9.73821 | mg/m3 | Dog | inhalation | chronic; 6 months | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fd3e4b096bca877efdf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/6/3?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID:15827092:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c360a44eeb20cd3d0f5d99cf6751e01b |
| ECHA | LOAEL | =14.6 | mg/m3 | Rat | inhalation | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/6/3?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828181_15828182:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af0549535ba922dbc0ef2301108f3bb4 |
| ECHA | LOAEL | =30 | mg/kg bw/day | Rat | oral | chronic; 100 days | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c620ace4b096bca878252d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/6/5?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID:15853857:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c405da4a940dcbae205f5d66bf139af1 |
| ECHA | LOAEL | =3000 | ppm | Mouse | oral | short-term; 14 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd8e4b0a7c65d227c52; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/6/2?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837997_15837998:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b05126fade684d61b15cf125ba13494 |
| ECHA | NOAEL | =2.9 | mg/m3 | Rat | inhalation | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/6/3?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828181_15828182:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_409ccd1066404231094c12e40371d4e5 |
| ECHA | NOAEL | =9.8495 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/6/3?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID:15828672:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d28b5005651b1455e6c7a309c89f882 |
| ECHA | NOAEL | =1000 | ppm | Mouse | oral | short-term; 14 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd8e4b0a7c65d227c52; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/6/2?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837997_15837998:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_77442d78fec605843fcfd50fde07b0b5 |
| ECHA | NOEL | =26.5 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaef0e4b0a7c65d1cbc84; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23353/7/6/2?documentUUID=040873e4-bba7-4c88-a533-e017ef8f65ba; STUDY_GROUP=ECHA IUCLID:15834924:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_36d27e9b3fe8930ea6fa04aac3fc943d |
ToxValDB ECOTOX 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =0.0294 | mmol | European Rabbit | environmental | subchronic; 35 days | subchronic | LONG_REF=Toxicol. Pathol.29(3): 308-319 Maurer,J.K., A. Molai, R.D. Parker, L. Li, G.J. Carr, W.M. Petroll, H.D. Cavanagh, and J.V. Jester Pathology of Ocular Irritation with Bleaching Agents in the Rabbit Low-Volume Eye Test 2001; TITLE=Pathology of Ocular Irritation with Bleaching Agents in the Rabbit Low-Volume Eye Test; AUTHOR=Maurer,J.K., A. Molai, R.D. Parker, L. Li, G.J. Carr, W.M. Petroll, H.D. Cavanagh, and J.V. Jester; DOI=10.1080/019262301316905264; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=97956; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Area; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15595728:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=08d8c1cbfecabe4b8c14149916a40469 |
| ToxValDB ECOTOX | LOEL | =0.0441 | mmol | European Rabbit | environmental | acute; 1 days | acute | LONG_REF=Toxicol. Pathol.29(3): 308-319 Maurer,J.K., A. Molai, R.D. Parker, L. Li, G.J. Carr, W.M. Petroll, H.D. Cavanagh, and J.V. Jester Pathology of Ocular Irritation with Bleaching Agents in the Rabbit Low-Volume Eye Test 2001; TITLE=Pathology of Ocular Irritation with Bleaching Agents in the Rabbit Low-Volume Eye Test; AUTHOR=Maurer,J.K., A. Molai, R.D. Parker, L. Li, G.J. Carr, W.M. Petroll, H.D. Cavanagh, and J.V. Jester; DOI=10.1080/019262301316905264; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97956; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Area; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601834_15601835:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d324d333f8d2a29142dc3884b6ff07ff |
| ToxValDB ECOTOX | LOEL | =0.6 | mM | Dog | injection | acute; 0.0417 days | acute | LONG_REF=Am. J. Physiol. Heart Circ. Physiol.275(4, Pt. 2): H1434 - H1440 Thompson,G.W., M. Horackova, and J.A. Armour Sensitivity of Canine Intrinsic Cardiac Neurons to H2O2 and Hydroxyl Radical 1998; TITLE=Sensitivity of Canine Intrinsic Cardiac Neurons to H2O2 and Hydroxyl Radical; AUTHOR=Thompson,G.W., M. Horackova, and J.A. Armour; DOI=10.1152/ajpheart.1998.275.4.H1434; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=108016; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Physiology: Neuroresponse; STUDY_GROUP=ECOTOX:15600435:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e623a2407a824a3e407bb7c8ad7bc35b |
| ToxValDB ECOTOX | LOEL | =100 | mM | Rat | oral | short-term; 14 days | short-term | LONG_REF=Toxicology227(3): 248-261 Sato,T., H. Yamamoto, N. Sawada, K. Nashiki, M. Tsuji, K. Muto, H. Kume, H. Sasaki, H. Arai, T. Nikawa, Y. Taketani, an Restraint Stress Alters the Duodenal Expression of Genes Important for Lipid Metabolism in Rat 2006; TITLE=Restraint Stress Alters the Duodenal Expression of Genes Important for Lipid Metabolism in Rat; AUTHOR=Sato,T., H. Yamamoto, N. Sawada, K. Nashiki, M. Tsuji, K. Muto, H. Kume, H. Sasaki, H. Arai, T. Nikawa, Y. Taketani, an; DOI=10.1016/j.tox.2006.08.009; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=96157; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Genetics: Cyp1A1 mRNA; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15607422:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=868c859d6962da1abb38071b57b251cf |
| ToxValDB ECOTOX | LOEL | =300 | mg/L | Mouse | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.38(7): 607-615 Weiner,M.L., C. Freeman, H. Trochimowicz, J. De Gerlache, S. Jacobi, G. Malinverno, W. Mayr, and J.F. Regnier 13-Week Drinking Water Toxicity Study of Hydrogen Peroxide with 6-Week Recovery Period in Catalase-Deficient Mice 2000; TITLE=13-Week Drinking Water Toxicity Study of Hydrogen Peroxide with 6-Week Recovery Period in Catalase-Deficient Mice; AUTHOR=Weiner,M.L., C. Freeman, H. Trochimowicz, J. De Gerlache, S. Jacobi, G. Malinverno, W. Mayr, and J.F. Regnier; DOI=10.1016/s0278-6915(00)00048-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=57046; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Histology: Hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610631_15610656:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f77a160577e7cb0f13d825458e5cc014 |
| ToxValDB ECOTOX | NOEL | =0.03 | mmol | Rat | injection | acute; 0.0208 days | acute | LONG_REF=J. Clin. Invest.88(6): 1886-1893 Salahudeen,A.K., E.C. Clark, and K.A. Nath Hydrogen Peroxide-Induced Renal Injury. A Protective Role for Pyruvate In Vitro and In Vivo 1991; TITLE=Hydrogen Peroxide-Induced Renal Injury. A Protective Role for Pyruvate In Vitro and In Vivo; AUTHOR=Salahudeen,A.K., E.C. Clark, and K.A. Nath; DOI=10.1172/JCI115511; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107749; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Immunological: Proteuria; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606506_15610614:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d36b25e76b8c7ac5f3a0f7e015436afa |
| ToxValDB ECOTOX | NOEL | =100 | mg/L | Mouse | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.38(7): 607-615 Weiner,M.L., C. Freeman, H. Trochimowicz, J. De Gerlache, S. Jacobi, G. Malinverno, W. Mayr, and J.F. Regnier 13-Week Drinking Water Toxicity Study of Hydrogen Peroxide with 6-Week Recovery Period in Catalase-Deficient Mice 2000; TITLE=13-Week Drinking Water Toxicity Study of Hydrogen Peroxide with 6-Week Recovery Period in Catalase-Deficient Mice; AUTHOR=Weiner,M.L., C. Freeman, H. Trochimowicz, J. De Gerlache, S. Jacobi, G. Malinverno, W. Mayr, and J.F. Regnier; DOI=10.1016/s0278-6915(00)00048-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=57046; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Histology: Hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610631_15610656:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9d61f0df4a251bb816c40ba046cde30c |
| ToxValDB ECOTOX | NOEL | =1000 | mg/L | Mouse | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.38(7): 607-615 Weiner,M.L., C. Freeman, H. Trochimowicz, J. De Gerlache, S. Jacobi, G. Malinverno, W. Mayr, and J.F. Regnier 13-Week Drinking Water Toxicity Study of Hydrogen Peroxide with 6-Week Recovery Period in Catalase-Deficient Mice 2000; TITLE=13-Week Drinking Water Toxicity Study of Hydrogen Peroxide with 6-Week Recovery Period in Catalase-Deficient Mice; AUTHOR=Weiner,M.L., C. Freeman, H. Trochimowicz, J. De Gerlache, S. Jacobi, G. Malinverno, W. Mayr, and J.F. Regnier; DOI=10.1016/s0278-6915(00)00048-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=57046; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595918_15597786_15597787:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=11f2c9826f6a0ded6ff8d75f03dc0297 |
| ToxValDB ECOTOX | NOEL | =3000 | mg/L | Mouse | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.38(7): 607-615 Weiner,M.L., C. Freeman, H. Trochimowicz, J. De Gerlache, S. Jacobi, G. Malinverno, W. Mayr, and J.F. Regnier 13-Week Drinking Water Toxicity Study of Hydrogen Peroxide with 6-Week Recovery Period in Catalase-Deficient Mice 2000; TITLE=13-Week Drinking Water Toxicity Study of Hydrogen Peroxide with 6-Week Recovery Period in Catalase-Deficient Mice; AUTHOR=Weiner,M.L., C. Freeman, H. Trochimowicz, J. De Gerlache, S. Jacobi, G. Malinverno, W. Mayr, and J.F. Regnier; DOI=10.1016/s0278-6915(00)00048-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=57046; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595918_15597786_15597787:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d39348e5cad48a4bbd723a3b544c483b |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =1.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632649:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d292fe300247cc97b8a00536cb71817 |
Regulatory source 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 30 | mg/kg/day | rat | oral | 6 days | - | p.11 |
| Regulatory source | - | 56.2 | mg/kg/day | rat | oral | 6 weeks | - | p.11 |
| Regulatory source | - | 100 | ppm | rat | oral | 2 weeks | - | p.11 |
| Regulatory source | repeated dose toxicity | 30 | mg/kg bw/day | rat | oral | - | repeated dose toxicity | p.30 |
| Regulatory source | - | 20 | mg/kg bw/day | rat | oral | 100 days | - | p.20 |
| Regulatory source | - | 56.2 | mg/kg/day | rat | oral | 6 days | - | p.20 |
| Regulatory source | - | 86 | mg/kg bw/day | rat | - | - | - | p.20 |
| Regulatory source | - | 100 | ppm | rat | oral | 6 days | - | p.20 |
| Regulatory source | - | 100 | mg/kg bw/d | - | - | - | - | p.92 |
| Regulatory source | - | 200 | mg/kg bw/d | rabbit | dermal | 6 days | - | p.90 |
| Regulatory source | - | 1000 | mg/kg bw/d | - | oral | 8 days | - | p.90 |
| Regulatory source | - | 1000 | mg/kg bw/d | - | oral | 15 days | - | p.90 |
| Regulatory source | - | 1000 | mg/kg bw/d | rabbit | oral | 28-day | - | p.90 |
| Regulatory source | carcinogenicity | 5 | % | mouse | oral | 25 weeks | carcinogenicity | p.34 |
| Regulatory source | developmental toxicity | 100 | mg/kg bw/d | - | - | developmental | developmental toxicity | p.92 |
| Regulatory source | developmental toxicity | 100 | mg/kg bw/d | - | oral | developmental | developmental toxicity | p.92 |
| Regulatory source | genotoxicity | 200 | mg/kg bw/d | - | oral | - | genotoxicity | p.91 |
| Regulatory source | repeated dose toxicity | 0.15 | % | mouse | oral | Sub-chronic | repeated dose toxicity | p.19 |
| Regulatory source | repeated dose toxicity | 20 | mg/kg bw/day | rat | oral | Chronic | repeated dose toxicity | p.21 |
| Regulatory source | repeated dose toxicity | 20 | mg/kg bw/day | rat | oral | 90 day | repeated dose toxicity | p.21 |
| Regulatory source | repeated dose toxicity | 20 | mg/kg bw/day | rat | oral | 100 days | repeated dose toxicity | p.61 |
| Regulatory source | repeated dose toxicity | 100 | ppm | rat | oral | Chronic | repeated dose toxicity | p.21 |
| Regulatory source | repeated dose toxicity | 100 | ppm | rat | oral | 90 day | repeated dose toxicity | p.63 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/d | rat | oral | 28 day | repeated dose toxicity | p.94 |
| Regulatory source | reproductive toxicity | 100 | mg/kg bw/d | human | oral | developmental | reproductive toxicity | p.95 |
| Regulatory source | reproductive toxicity | 1129 | - | human | oral | developmental | reproductive toxicity | p.93 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | BBX060AN9V | UNII | - | - | - | chemical | - |