Hydrolyzed Glycyrrhizinate

INCI: HYDROLYZED GLYCYRRHIZINATE

CAS Number
Not specifically assigned (parent Glycyrrhizic Acid CAS 1405-86-3; sodium salt CAS 56649-78-6; dipotassium salt CAS 68797-35-3)
Function
Skin conditioning, soothing, anti-inflammatory (licorice-derived)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR Parts 700โ€“740

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Glycyrrhetinic acid (hydrolysis product of glycyrrhizin) can exhibit pseudo-aldosterone activity at high systemic doses โ€” not a concern at typical cosmetic use levels (<1%). Confirm hydrolysis degree and composition with supplier CoA.

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Concern Level: Low

Frequently Asked Questions

Is Hydrolyzed Glycyrrhizinate safe in cosmetics?

Glycyrrhetinic acid (hydrolysis product of glycyrrhizin) can exhibit pseudo-aldosterone activity at high systemic doses โ€” not a concern at typical cosmetic use levels (<1%). Confirm hydrolysis degree and composition with supplier CoA. The EU classifies Hydrolyzed Glycyrrhizinate as "permitted". Safety rating: GOOD.

Is Hydrolyzed Glycyrrhizinate allowed in the EU?

Hydrolyzed Glycyrrhizinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydrolyzed Glycyrrhizinate do in cosmetics?

Hydrolyzed Glycyrrhizinate functions as: Skin conditioning, soothing, anti-inflammatory (licorice-derived). It is classified as a cosmetic ingredient in our database. CAS number: Not specifically assigned (parent Glycyrrhizic Acid CAS 1405-86-3; sodium salt CAS 56649-78-6; dipotassium salt CAS 68797-35-3).

What is the Margin of Safety for Hydrolyzed Glycyrrhizinate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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