Hydrolyzed Nettle Leaf Extract

INCI: HYDROLYZED URTICA DIOICA LEAF EXTRACT

CAS Number
Not confirmed — parent *Urtica dioica* extract CAS: 84012-40-8 (verify hydrolysed variant)
Function
Skin conditioning, hair conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted, not prohibited or restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Data-poor ingredient with limited published safety data. Parent plant contains urticating compounds (histamine, acetylcholine, formic acid) that should be degraded by hydrolysis, but no published confirmation available. No CIR report exists. Recommend supplier certificate of analysis and HRIPT data before use.

⚠️
Concern Level: Moderate

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is Hydrolyzed Nettle Leaf Extract safe in cosmetics?

Data-poor ingredient with limited published safety data. Parent plant contains urticating compounds (histamine, acetylcholine, formic acid) that should be degraded by hydrolysis, but no published confirmation available. No CIR report exists. Recommend supplier certificate of analysis and HRIPT data before use. The EU classifies Hydrolyzed Nettle Leaf Extract as "permitted". Safety rating: MODERATE.

Is Hydrolyzed Nettle Leaf Extract allowed in the EU?

Hydrolyzed Nettle Leaf Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydrolyzed Nettle Leaf Extract do in cosmetics?

Hydrolyzed Nettle Leaf Extract functions as: Skin conditioning, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not confirmed — parent *Urtica dioica* extract CAS: 84012-40-8 (verify hydrolysed variant).

What is the Margin of Safety for Hydrolyzed Nettle Leaf Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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