NOAEL Studies
Active Ingredient
Hydroquinone NOAEL Studies
INCI: HYDROQUINONE
CAS: 123-31-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =1 | % | rat | oral | subchronic | general toxicity | 1, p.2 |
| CIR Safety Assessment | NOAEL | =2 | % | rabbit | dermal | 6 months | depigmentation | 1, p.2 |
| CIR Safety Assessment | NOAEL | =3840 | mg/kg | rat | dermal | 14 days | general toxicity | 2, p.3 |
| CIR Safety Assessment | NOAEL | =4800 | mg/kg | mouse | dermal | 14 days | general toxicity | 2, p.3 |
ECHA 50 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 50 | mg/kg bw/day | mouse | oral: gavage | - | chronic toxicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=3b27b410-fc2f-4726-bc42-24eb1e762d3b_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=3b27b410-fc2f-4726-bc42-24eb1e762d3b/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=false; entry_uuid=437695b5-b835-487b-b6db-35e29158f151 |
| ECHA | LOAEL | 64 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: sub-chronic oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=253e020f-2f3c-4e3a-aa86-ce38a52cb5af_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=253e020f-2f3c-4e3a-aa86-ce38a52cb5af/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=2007; basis=other:; key_result=false; entry_uuid=6b07278d-734a-45d6-9812-bef34c8c0427 |
| ECHA | LOAEL | 25 | mg/kg bw/day | rat | oral: gavage | - | chronic toxicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=cc831384-1c70-46c8-a7bf-9557aed0e555_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=cc831384-1c70-46c8-a7bf-9557aed0e555/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=false; entry_uuid=5b3b30a4-d7ed-4767-9878-430ba2bc7188 |
| ECHA | LOAEL | 100 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=5b7295cf-d65c-43a3-805b-c0a5be05f96e_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=5b7295cf-d65c-43a3-805b-c0a5be05f96e/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=false; entry_uuid=ba177f69-316c-437c-8b7d-bd5212b39bd8 |
| ECHA | LOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=b6a821f9-7986-4df7-bbd6-088d310a7898_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=b6a821f9-7986-4df7-bbd6-088d310a7898/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=false; entry_uuid=c447cca4-6826-4b97-96a4-212c5b53652b |
| ECHA | LOAEL | 250 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=1a2a7f38-a6bf-4ab0-b27c-583ebec751c2_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=1a2a7f38-a6bf-4ab0-b27c-583ebec751c2/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=false; entry_uuid=6cb245ae-9646-484a-b32c-886b7e21c600 |
| ECHA | NOAEL | 15 | mg/kg bw/day | rat | oral: gavage | - | two-generation reproductive toxicity | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=ffcf62aa-18b3-4d98-8b50-7b116448c9b2_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=ffcf62aa-18b3-4d98-8b50-7b116448c9b2/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1993; basis=clinical signs; key_result=false; entry_uuid=8a7cc5a1-f602-4e02-8e47-f36ffd2712e3 |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | two-generation reproductive toxicity | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=ffcf62aa-18b3-4d98-8b50-7b116448c9b2_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=ffcf62aa-18b3-4d98-8b50-7b116448c9b2/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1993; basis=reproductive performance; key_result=false; entry_uuid=23a84863-c1f6-4de4-89c2-3d9161ccdf72 |
| ECHA | NOAEL | 20 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: sub-chronic oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=253e020f-2f3c-4e3a-aa86-ce38a52cb5af_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=253e020f-2f3c-4e3a-aa86-ce38a52cb5af/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=2007; basis=other:; key_result=false; entry_uuid=b97b9b6d-bef7-40f8-a0bf-ab84dbce92c1 |
| ECHA | NOAEL | 73.9 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=59bc4529-ebd6-4d22-a53c-076add3336ef_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=59bc4529-ebd6-4d22-a53c-076add3336ef/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1998; basis=other:; key_result=false; entry_uuid=15dee59b-d3dc-4263-a0d1-547685689ec9 |
| ECHA | NOAEL | 109.6 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=59bc4529-ebd6-4d22-a53c-076add3336ef_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=59bc4529-ebd6-4d22-a53c-076add3336ef/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1998; basis=other:; key_result=false; entry_uuid=b275406c-cf29-46d1-a40a-6bf8fdbb1875 |
| ECHA | NOAEL | 50 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=9e9fc208-45aa-43c3-8c4e-8686ffb94bf3_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=9e9fc208-45aa-43c3-8c4e-8686ffb94bf3/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=false; entry_uuid=2116ffe3-6a79-4d7b-9312-44cb2d7f9a14 |
| ECHA | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=b6a821f9-7986-4df7-bbd6-088d310a7898_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=b6a821f9-7986-4df7-bbd6-088d310a7898/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; key_result=false; entry_uuid=9d34c0b2-99a8-432b-8629-c68d6672e880 |
| ECHA | NOAEL | 125 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=1a2a7f38-a6bf-4ab0-b27c-583ebec751c2_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=1a2a7f38-a6bf-4ab0-b27c-583ebec751c2/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; key_result=false; entry_uuid=0be95e9e-59cc-47a2-a890-87c275340042 |
| ECHA | NOEL | 1486 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=d1adebc1-7e17-47c7-a843-17d6ceb3c7e7_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=d1adebc1-7e17-47c7-a843-17d6ceb3c7e7/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=21fe0b99-4d43-4e29-8a0e-81065389ddf6 |
| ECHA | NOEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=d1ec676a-b040-450f-a855-38efc50e1dcd_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=d1ec676a-b040-450f-a855-38efc50e1dcd/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=body weight and weight gain; key_result=false; entry_uuid=a194c843-b733-4926-8464-7448b5464c78 |
| ECHA | NOEL | 4800 | mg/kg bw/day | mouse | - | - | short-term repeated dose toxicity: dermal | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=a6d96739-6382-4f3b-8a05-013b666ed5bd_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=a6d96739-6382-4f3b-8a05-013b666ed5bd/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1989; ReportDate=1989-10-31; basis=other:; key_result=false; entry_uuid=8dfdd50c-2566-452d-bd6b-fbdb37aad033 |
| ECHA | NOEL | 25 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=ffcfbb78-4416-449e-9b26-9d0f3733cb0f_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=ffcfbb78-4416-449e-9b26-9d0f3733cb0f/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=false; entry_uuid=270a75aa-e785-4f77-b1a7-d8691cd318ad |
| ECHA | NOEL | 75 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=ffcfbb78-4416-449e-9b26-9d0f3733cb0f_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=ffcfbb78-4416-449e-9b26-9d0f3733cb0f/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=skeletal malformations; key_result=false; entry_uuid=4dd62ab8-c1a3-4cfb-b342-a8dfb82d9634 |
| ECHA | NOEL | 300 | mg/kg bw/day | rat | oral: gavage | - | fertility, other | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=9a1c20ab-d156-4564-80dd-06d3dd319ad6_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=9a1c20ab-d156-4564-80dd-06d3dd319ad6/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1984; ReportDate=1984-08-10; basis=reproductive performance; key_result=false; entry_uuid=4b345ec2-fef4-4bb8-99ff-1bc2088a74ba |
| ECHA | NOEL | 3840 | mg/kg bw/day | rat | - | - | short-term repeated dose toxicity: dermal | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=ed4787db-c732-4c21-b1cc-618ab3a8c0b7_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=ed4787db-c732-4c21-b1cc-618ab3a8c0b7/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1989; ReportDate=1989-10-31; basis=other:; key_result=false; entry_uuid=844278e2-1e94-4b86-840e-3f4da1550385 |
| ECHA | NOEL | 368 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=3de445ca-cd68-4353-af8e-a2c9eab13fb8_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=3de445ca-cd68-4353-af8e-a2c9eab13fb8/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=36fa3e15-6844-4621-a2bc-d594c730717e |
| ECHA | NOEL | 50 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6z; document=5b7295cf-d65c-43a3-805b-c0a5be05f96e_2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb.i6d; document_key=5b7295cf-d65c-43a3-805b-c0a5be05f96e/2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=false; entry_uuid=dad41e6e-7fbc-44dc-b04f-e4b3d8e70209 |
| ECHA | LEL | =600 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/3/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15809897_15809898:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_78587d033c4e86dc855935be0cbad754 |
| ECHA | LEL | =300 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/3/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15809897_15809898:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26df08432dfb7c1b607b9ec87fd5a8dd |
| ECHA | LEL | =351 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30ad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/8?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15816909:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7f7f9d4556c743d6b3b25adf56158781 |
| ECHA | LEL | =368 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30ad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/8?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816910_15816911:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6f42d97715716c8d50132680c5538144 |
| ECHA | LEL | =1046 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/8?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15819127:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_59d79e5e5ba27c10c168a1e850745ed0 |
| ECHA | LEL | =1486 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/8?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819128_15819129:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8851fcdc072a0c7fefa70445260dd3c5 |
| ECHA | LEL | >=25 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/8?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819620_15819622:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb703b1bd3c24d8df2c72acc8f917b30 |
| ECHA | LOAEL | =100 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/8?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15817303:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ae5f9a56035514b7c765c6144109661b |
| ECHA | LOAEL | =50 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/8?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819619_15819621:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_36d780cc8105bdb88770464cd55ace4f |
| ECHA | LOAEL | =64 | mg/kg bw/day | Rat | oral | - | repeat dose other | GUIDELINE=EPA OTS 798.6050 (Neurotoxicity Screening Battery); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4ede; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/10/1?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825634_15825635:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25541b0548bcce7c7f39aa1fe1f24cae |
| ECHA | LOAEL | =250 | mg/kg bw/day | Mouse | oral | short-term; 12 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4ee4b0a7c65d2213eb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/6/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831515_15831516:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1baa3de28ba894762e94a5277663c89d |
| ECHA | LOAEL | =500 | mg/kg bw/day | Rat | oral | short-term; 12 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4ee4b0a7c65d2213f7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/6/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841784_15841785:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_615eb321ec3c0f64dc35a3ca9e22ad45 |
| ECHA | NOAEL | =20 | mg/kg bw/day | Rat | oral | - | repeat dose other | GUIDELINE=EPA OTS 798.6050 (Neurotoxicity Screening Battery); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4ede; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/10/1?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825634_15825635:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f779170b80ca73b1b16a1e95545a2734 |
| ECHA | NOAEL | =73.9 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e09e4b096bca877820d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/6/4?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15826388:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b5e0006263551e0f153245ecd9559861 |
| ECHA | NOAEL | =109.6 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e09e4b096bca877820d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/6/4?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15826389:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_781aac688394b362d93ad9d8ddf0cfab |
| ECHA | NOAEL | =125 | mg/kg bw/day | Mouse | oral | short-term; 12 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4ee4b0a7c65d2213eb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/6/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831515_15831516:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_95319c4bb4f6133537b0e69b29f9f2aa |
| ECHA | NOAEL | =50 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2855; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/6/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15834933:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_31d8610317ae54e8bbd58bdefd75a771 |
| ECHA | NOAEL | =250 | mg/kg bw/day | Rat | oral | short-term; 12 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4ee4b0a7c65d2213f7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/6/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841784_15841785:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_86f37601a4eeab4171dcfaaa91040311 |
| ECHA | NOAEL | =15 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/9/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=P0: clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855878_15856304_15856621:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38c8c896e15a84837b5ff221db2069dc |
| ECHA | NOAEL | =150 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/9/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855878_15856304_15856621:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3b7abf7e00844959f05638f787e437fe |
| ECHA | NOEL | =50 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/8?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15817304:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9f36cba2c00969da6640f944d2fe477f |
| ECHA | NOEL | =100 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbeae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/9/3?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821706:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2f16791b615855542e16e158c3601aab |
| ECHA | NOEL | =75 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbeb4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/9/3?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821922:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_800cee2f4a3bd319a5fc43c14fae1e68 |
| ECHA | NOEL | =25 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbeb4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/9/3?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15823187:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_af8a930c98ffbde3993f7c6486994954 |
| ECHA | NOEL | =4800 | mg/kg bw/day | Mouse | dermal | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ec3e4b096bca877af6c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/6/4?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15826631:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_57918c6c2b9aeb29d843daa0ea903d5b |
| ECHA | NOEL | =3840 | mg/kg bw/day | Rat | dermal | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f71e4b096bca877d815; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/6/4?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15826848:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_351d70a3d850141771d4eafdfcf979a2 |
| ECHA | NOEL | =300 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6231/7/9/2?documentUUID=2ffe0e01-05b2-40ec-b22b-fcda2e6c52bb; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855878_15856304_15856621:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ebd61f8d13f4576061c7d452c9eb4bd |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | - |
WHO/JECFA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOAEL | =15 | mg/kg bw/day | - | - | - | Reproductive toxicity | document_id=ehc_ehc_ehc157; title=Hydroquinone (EHC 157, 1994); path=mirror/documents/ehc/ehc/ehc157.htm; row_hash=6c374386aec24f34; raw_unit=mg/kg per day; context=The no-observed- adverse-effect level (NOAEL) for parental toxicity was determined to be 15 mg/kg per day, and for reproductive effects through two generations it was 150 mg/kg per day. |
| WHO/JECFA | NOAEL | =300 | mg/kg bw/day | Rat | - | - | Reproductive toxicity | document_id=ehc_ehc_ehc157; title=Hydroquinone (EHC 157, 1994); path=mirror/documents/ehc/ehc/ehc157.htm; row_hash=07a4650048fac8f0; raw_unit=mg/kg; context=Findings of increased resorption rates in rats given hydroquinone orally at about 100 mg/kg per day were not confirmed in this study, and, consequently, the NOAEL for maternal reproductive effects and teratogenicity was 300 mg/kg. |
| WHO/JECFA | NOAEL | =150 | mg/kg bw/day | Rat | - | two-generation | Reproductive toxicity | document_id=ehc_ehc_ehc157; title=Hydroquinone (EHC 157, 1994); path=mirror/documents/ehc/ehc/ehc157.htm; row_hash=e04dfd8333bf9b9d; raw_unit=mg/kg per day; context=In a two-generation reproduction study in rats the NOAEL for reproductive effects through two generations was 150 mg/kg per day (the highest tested dose). |
| WHO/JECFA | NOAEL | =15 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc157; title=Hydroquinone (EHC 157, 1994); path=mirror/documents/ehc/ehc/ehc157.htm; row_hash=c3a423c7322a301a; raw_unit=mg/kg; context=El nivel sin efectos adversos observados (NOAEL) fue de 15 mg/kg al día por lo que hace a la toxicidad materna, y de 150 mg/kg al día en lo referente a los efectos sobre la reproducción observados a lo largo de dos generaciones. |
| WHO/JECFA | NOEL | =25 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc157; title=Hydroquinone (EHC 157, 1994); path=mirror/documents/ehc/ehc/ehc157.htm; row_hash=81e689b0f46371f4; raw_unit=mg/kg per day; context=The NOEL for maternal toxicity was 25 mg/kg per day and the NOEL for developmental toxicity was 75 mg/kg per day. |
| WHO/JECFA | NOEL | =100 | mg/kg bw | Rat | - | - | Developmental toxicity | document_id=ehc_ehc_ehc157; title=Hydroquinone (EHC 157, 1994); path=mirror/documents/ehc/ehc/ehc157.htm; row_hash=f1fb95f9f80e7003; raw_unit=mg/kg; context=No compound-related teratogenic effects were produced at this dose level; thus, 100 mg/kg was considered the NOEL for maternal and developmental toxicity in rats. |
| WHO/JECFA | NOEL | =25 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc157; title=Hydroquinone (EHC 157, 1994); path=mirror/documents/ehc/ehc/ehc157.htm; row_hash=0d41b9a44658b8d7; raw_unit=mg/kg; context=En el conejo, el nivel sin efectos observados (NOEL) por lo que se refiere a la toxicidad materna fue de 25 mg/kg al día, y de 75 mg/kg al día en lo que respecta a la toxicidad ontogénica. |
NTP ICE cancer 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=7645; Record_ID=cancer_6244; Data_Type=WOE; Formulation_Name=Hydroquinone; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/33; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE cancer | POLY-3 lowest dose | 50 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=7642; Record_ID=cancer_6245; Data_Type=In Vivo; Formulation_Name=Hydroquinone; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=50; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Level_of_Evidence=Some evidence; Tissue=Liver; Lesion=Hepatocellular carcinoma or hepatocellular adenoma; Reference=TR-366; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr366/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE cancer | Top dose | 100 | mg/kg | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7637; Record_ID=cancer_6241; Data_Type=In Vivo; Formulation_Name=Hydroquinone; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=100; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-366; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr366/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE cancer | Top dose | 50 | mg/kg | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7647; Record_ID=cancer_6243; Data_Type=In Vivo; Formulation_Name=Hydroquinone; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=50; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Female; Route=Gavage; Reference=TR-366; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr366/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10436; RecordID=ARPathway2016_717; DatasetName=ARPathway2016; DTXSID=DTXSID7020716; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
NTP ICE skin sensitization 42 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 2.89 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2682; Record_ID=skin_sensitization_invitro_635; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=2.89; Reported_Response_Unit=ug/mL; Response=2.89; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD54, EC200 | 2.643 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2730; Record_ID=skin_sensitization_invitro_645; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=2.64299999999999; Reported_Response_Unit=ug/mL; Response=2.643; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD54, EC200 | 6.9 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3172; Record_ID=skin_sensitization_invitro_734; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=6.9; Reported_Response_Unit=ug/mL; Response=6.9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 2.13 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1992; Record_ID=skin_sensitization_invitro_502; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=2.13; Reported_Response_Unit=ug/mL; Response=2.13; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 2.1 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2640; Record_ID=skin_sensitization_invitro_622; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=2.1; Reported_Response_Unit=ug/mL; Response=2.1; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 1.4 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2680; Record_ID=skin_sensitization_invitro_635; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=1.4; Reported_Response_Unit=ug/mL; Response=1.4; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 1.331 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2729; Record_ID=skin_sensitization_invitro_645; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=1.331; Reported_Response_Unit=ug/mL; Response=1.331; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 2.124 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2883; Record_ID=skin_sensitization_invitro_679; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=2.1240000000000001; Reported_Response_Unit=ug/mL; Response=2.124; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 5.6 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2914; Record_ID=skin_sensitization_invitro_687; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=5.6; Reported_Response_Unit=ug/mL; Response=5.6; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | <4.3 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2979; Record_ID=skin_sensitization_invitro_700; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=4.3; Reported_Response_Unit=ug/mL; Response=4.3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 6.3 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3091; Record_ID=skin_sensitization_invitro_708; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=6.3; Reported_Response_Unit=ug/mL; Response=6.3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 3.6 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3117; Record_ID=skin_sensitization_invitro_726; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=3.6; Reported_Response_Unit=ug/mL; Response=3.6; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | <7.9 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3176; Record_ID=skin_sensitization_invitro_734; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CD86, EC150; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=7.9; Reported_Response_Unit=ug/mL; Response=7.9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 0.3 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8343; Record_ID=skin_sensitization_invitro_2313; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=2.72479564; Reported_Response_Unit=uM; Conversion_Factor_Value=110.112; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.3; Converted_Response_Unit=ug/mL; Response=0.3; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CD86, EC150 | 0.57 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8564; Record_ID=skin_sensitization_invitro_2364; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=0.57; Reported_Response_Unit=ug/mL; Response=0.57; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CV70 | 5.52 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8568; Record_ID=skin_sensitization_invitro_2364; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=U-SENS; Endpoint=CV70; Reported_Response=5.52; Reported_Response_Unit=ug/mL; Response=5.52; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CV75 | 5 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1994; Record_ID=skin_sensitization_invitro_502; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CV75; Reported_Response=5; Reported_Response_Unit=ug/mL; Response=5; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CV75 | 44 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2916; Record_ID=skin_sensitization_invitro_687; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CV75; Reported_Response=44; Reported_Response_Unit=ug/mL; Response=44; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CV75 | 12.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2977; Record_ID=skin_sensitization_invitro_700; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CV75; Reported_Response=12.7; Reported_Response_Unit=ug/mL; Response=12.7; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CV75 | 9.5 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3093; Record_ID=skin_sensitization_invitro_708; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CV75; Reported_Response=9.5; Reported_Response_Unit=ug/mL; Response=9.5; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CV75 | 6 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3119; Record_ID=skin_sensitization_invitro_726; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CV75; Reported_Response=6; Reported_Response_Unit=ug/mL; Response=6; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | CV75 | 23.6 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3174; Record_ID=skin_sensitization_invitro_734; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=h-CLAT; Endpoint=CV75; Reported_Response=23.6; Reported_Response_Unit=ug/mL; Response=23.6; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | Depletion Cys | 83.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=568; Record_ID=skin_sensitization_invitro_165; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=83.3; Reported_Response_Unit=%; Response=83.3; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | Depletion Cys | 99.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1106; Record_ID=skin_sensitization_invitro_300; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=99.6; Reported_Response_Unit=%; Response=99.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | Depletion Lys | 51.1 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=566; Record_ID=skin_sensitization_invitro_165; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=51.1; Reported_Response_Unit=%; Response=51.1; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | Depletion Lys | 53.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1105; Record_ID=skin_sensitization_invitro_300; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=53.7; Reported_Response_Unit=%; Response=53.7; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 67.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=570; Record_ID=skin_sensitization_invitro_165; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=67.2; Reported_Response_Unit=%; Response=67.2; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 77 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1107; Record_ID=skin_sensitization_invitro_300; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=77; Reported_Response_Unit=%; Response=77; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC1.5 | 9.797 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4974; Record_ID=skin_sensitization_invitro_1152; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=9.7970000000000006; Reported_Response_Unit=uM; Response=9.797; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 51.29 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4975; Record_ID=skin_sensitization_invitro_1152; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=51.287999999999997; Reported_Response_Unit=uM; Response=51.29; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 0.07 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13106; Record_ID=skin_sensitization_invivo_3107; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=7.00E-02; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lea 1999; 10594297; 10.1053/AJCD01000213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 0.08 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13107; Record_ID=skin_sensitization_invivo_3108; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=0.08; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lea 1999; 10594297; 10.1053/AJCD01000213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 1.34 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13108; Record_ID=skin_sensitization_invivo_3109; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=1.34; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lea 1999; 10594297; 10.1053/AJCD01000213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 0.11 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13109; Record_ID=skin_sensitization_invivo_3111; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=0.11; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 0.19 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13111; Record_ID=skin_sensitization_invivo_3113; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=0.19; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lea 1999; 10594297; 10.1053/AJCD01000213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 0.23 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13114; Record_ID=skin_sensitization_invivo_3116; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=0.23; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lea 1999; 10594297; 10.1053/AJCD01000213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 0.33 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13115; Record_ID=skin_sensitization_invivo_3117; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=0.33; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lea 1999; 10594297; 10.1053/AJCD01000213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 0.37 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13116; Record_ID=skin_sensitization_invivo_3118; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=0.37; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lea 1999; 10594297; 10.1053/AJCD01000213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 0.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13117; Record_ID=skin_sensitization_invivo_3119; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=0.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lea 1999; 10594297; 10.1053/AJCD01000213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | EC3 | 1.67 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13119; Record_ID=skin_sensitization_invivo_3121; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=LLNA; Endpoint=EC3; Response=1.67; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lea 1999; 10594297; 10.1053/AJCD01000213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | IC50 | 130.7 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4976; Record_ID=skin_sensitization_invitro_1152; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=130.72999999999999; Reported_Response_Unit=uM; Response=130.7; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
| NTP ICE skin sensitization | Imax | 16.39 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4977; Record_ID=skin_sensitization_invitro_1152; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020716; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=16.39; Reported_Response_Unit=Unitless; Response=16.39; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020716; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020716 |
EPA ToxRefDB v3 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =50 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5622; toxval_study_source_id=studyid5622_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight|in life observation-mortality-mortality|pathology microscopic-kidney-regeneration|pathology microscopic-kidney-nephropathy|in life observation-clinical signs-lethargy|pathology microscopic-kidney-degeneration|in life observation-clinical signs-convulsions|in life observation-clinical signs-tremors|in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth; dose_level=2; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Rat subchronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =100 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5623; toxval_study_source_id=studyid5623_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-lethargy|organ weight-liver-relative to body weight|in life observation-clinical signs-tremors|in life observation-mortality-mortality|organ weight-liver-absolute|in life observation-clinical signs-convulsions|pathology microscopic-stomach-ulcer|pathology microscopic-stomach-inflammation|pathology microscopic-stomach-hyperplasia; dose_level=3; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Mouse subchronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =25 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5623; toxval_study_source_id=studyid5623_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-liver-absolute|in life observation-clinical signs-lethargy|in life observation-clinical signs-tremors|in life observation-mortality-mortality|in life observation-clinical signs-convulsions|pathology microscopic-stomach-ulcer|pathology microscopic-stomach-inflammation|pathology microscopic-stomach-hyperplasia; dose_level=1; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Mouse subchronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =200 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5622; toxval_study_source_id=studyid5622_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-regeneration|in life observation-clinical signs-lethargy|pathology microscopic-stomach-inflammation|pathology microscopic-kidney-degeneration|pathology microscopic-stomach-hyperplasia|pathology microscopic-kidney-nephropathy; dose_level=4; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Rat subchronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =50 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=5624; toxval_study_source_id=studyid5624_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-atrophy|pathology microscopic-kidney-regeneration|pathology microscopic-kidney-fibrosis|organ weight-kidney-relative to body weight|pathology microscopic-kidney-degeneration|pathology microscopic-kidney-dilatation|pathology microscopic-kidney-glomerulosclerosis|in life observation-body weight-body weight|pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-casts protein|pathology microscopic-kidney-inflammation; dose_level=2; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Rat chronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =100 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5625; toxval_study_source_id=studyid5625_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-thyroid gland-hyperplasia|in life observation-body weight-body weight; dose_level=2; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Mouse chronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =25 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5622; toxval_study_source_id=studyid5622_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|in life observation-mortality-mortality|pathology microscopic-kidney-regeneration|in life observation-clinical signs-lethargy|in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth|organ weight-liver-relative to body weight|organ weight-liver-absolute|in life observation-clinical signs-tremors|in life observation-clinical signs-convulsions|pathology microscopic-kidney-degeneration; dose_level=1; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Rat subchronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5622; toxval_study_source_id=studyid5622_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight|pathology microscopic-kidney-regeneration|pathology microscopic-stomach-inflammation|in life observation-clinical signs-lethargy|in life observation-mortality-mortality|pathology microscopic-stomach-hyperplasia|organ weight-liver-absolute|pathology microscopic-kidney-nephropathy|in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth|pathology microscopic-kidney-degeneration; dose_level=0; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Rat subchronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =50 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5623; toxval_study_source_id=studyid5623_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|in life observation-clinical signs-tremors|organ weight-liver-absolute|in life observation-clinical signs-lethargy|pathology microscopic-stomach-ulcer|in life observation-clinical signs-convulsions|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-inflammation|organ weight-liver-relative to body weight; dose_level=2; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Mouse subchronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =100 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5622; toxval_study_source_id=studyid5622_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight|in life observation-clinical signs-lethargy|pathology microscopic-stomach-inflammation|pathology microscopic-kidney-regeneration|in life observation-mortality-mortality|organ weight-liver-absolute|pathology microscopic-kidney-nephropathy|pathology microscopic-stomach-hyperplasia|in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth|pathology microscopic-kidney-degeneration; dose_level=3; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Rat subchronic); dsstox_substance_id=DTXSID7020716; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =64 | mg/kg bw/day | Rat | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.45(1): 70-78 Topping,D.C., L.G. Bernard, J.L. O\\\'Donoghue, and J.C. English Hydroquinone: Acute and Subchronic Toxicity Studies with Emphasis on Neurobehavioral and Nephrotoxic Effects 2007; TITLE=Hydroquinone: Acute and Subchronic Toxicity Studies with Emphasis on Neurobehavioral and Nephrotoxic Effects; AUTHOR=Topping,D.C., L.G. Bernard, J.L. O\'Donoghue, and J.C. English; DOI=10.1016/j.fct.2006.07.019; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=115077; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Intoxication: Intoxication, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15612620:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=6f03f5c89f25e510308cd34204014fd0 |
| ToxValDB ECOTOX | NOEL | =80 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603883_15607230:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a0ef2c6aa5bc4553ba853b8ce9b48d25 |
| ToxValDB ECOTOX | NOEL | =120 | mg/kg bw/day | Mouse | oral | short-term; 2 days | short-term | LONG_REF=Mutat. Res.343(2/3): 157-183 Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens 1995; TITLE=The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens; AUTHOR=Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa; DOI=10.1016/0165-1218(95)90082-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75052; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15608304:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e3cc4f5539d7f4b26d65f9f0b0ccb708 |
| ToxValDB ECOTOX | NOEL | =20 | mg/kg bw/day | Rat | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.45(1): 70-78 Topping,D.C., L.G. Bernard, J.L. O\\\'Donoghue, and J.C. English Hydroquinone: Acute and Subchronic Toxicity Studies with Emphasis on Neurobehavioral and Nephrotoxic Effects 2007; TITLE=Hydroquinone: Acute and Subchronic Toxicity Studies with Emphasis on Neurobehavioral and Nephrotoxic Effects; AUTHOR=Topping,D.C., L.G. Bernard, J.L. O\'Donoghue, and J.C. English; DOI=10.1016/j.fct.2006.07.019; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=115077; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Intoxication: Intoxication, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15612621:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=cf521ce2de3b9920a698bb2394bce0ba |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =2.1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631255:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b3c13a67f4f05f675b626155a37bef30 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | =25 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e0ae4b0a676289df20d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=reduced body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=HESS:15638552:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_db2fa7d1bb0eac26c6f15cc03c4e5bf2 |
ToxValDB PPRTV (CPHEA) 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | NOAEL | =4.3 | mg/kg bw/day | Human | oral | chronic; 5 months | clinical | LONG_REF=Carlson and Brewer 1953; AUTHOR=Carlson and Brewer; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1769; TOXICOLOGICAL_EFFECT=Hematologic, Urinary; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=PPRTV (CPHEA):15653846:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4195cd552ce41acef53fd1a3620dec15 |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.4 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Carlson and Brewer 1953; AUTHOR=Carlson and Brewer; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1769; TOXICOLOGICAL_EFFECT=Urinary, Hematologic; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653556_15653711:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0066f3effef845bb3851143f6fef866a |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfD | =0.04 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650168:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b10eab98dcdf896f98a7aa5e6090b573 |
ToxValDB ToxRefDB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =25 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=(1989). \'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Mouse subchronic); TITLE=NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5623; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-lethargy|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: in life observation-clinical signs-tremors|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-convulsions|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-ulcer|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB:15709715:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a230a9217cb34b0b0221f07589eeb0f7 |
| ToxValDB ToxRefDB | LOAEL | =200 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=(1989). \'NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 366: 1-248. (Rat subchronic); TITLE=NTP Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5622; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-regeneration|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-kidney-nephropathy|systemic: in life observation-clinical signs-lethargy|systemic: pathology microscopic-kidney-degeneration|systemic: pathology microscopic-stomach-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709710_15709711_15709712:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f4bbecdb864e4645686c5e08b98b6966 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | XV74C1N1AE | UNII | - | - | - | chemical | - |