Hydroxymethyl Pregnacalciferol

INCI: HYDROXYMETHYL PREGNACALCIFEROL

CAS Number
Not confirmed in public databases
Function
Skin conditioning (vitamin D3 analog)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically restricted under 21 CFR; no CIR review identified

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Active vitamin D analog with potential risk of systemic calcium metabolism disruption (hypercalcemia); pharmacological activity raises classification concerns under Reg. (EC) 1223/2009 Art. 2.

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Concern Level: Moderate

Frequently Asked Questions

Is Hydroxymethyl Pregnacalciferol safe in cosmetics?

Active vitamin D analog with potential risk of systemic calcium metabolism disruption (hypercalcemia); pharmacological activity raises classification concerns under Reg. (EC) 1223/2009 Art. 2. The EU classifies Hydroxymethyl Pregnacalciferol as "permitted". Safety rating: MODERATE.

Is Hydroxymethyl Pregnacalciferol allowed in the EU?

Hydroxymethyl Pregnacalciferol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxymethyl Pregnacalciferol do in cosmetics?

Hydroxymethyl Pregnacalciferol functions as: Skin conditioning (vitamin D3 analog). It is classified as a cosmetic ingredient in our database. CAS number: Not confirmed in public databases.

What is the Margin of Safety for Hydroxymethyl Pregnacalciferol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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