Is Hydroxypinacolone Retinoate safe in cosmetics?
Hydroxypinacolone Retinoate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
EXCELLENT
Active Ingredient
Hydroxypinacolone Retinoate
INCI: HYDROXYPINACOLONE RETINOATE
Hydroxypinacolone Retinoate (CAS 893412-73-2) is a cosmetic active ingredient functioning as skin-conditioning, anti-aging. EU Regulation 1223/2009 status: permitted, max 0.5%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 893412-73-2 →
Function
skin-conditioning, anti-aging
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.5%
US US Status
permitted
US Notes
OTC cosmetic ingredient; no CIR monograph; generally considered low-irritation retinoid
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxypinacolone Retinoate.
Calculate MoS for your specific formulation with the MoS Calculator.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: RAR, RXR
LOEC: 100 nM
EU status: under_review (RAR agonist; EU retinoid assessment)
agonist (RAR/RXR)
Editorial summary
Preliminary editorial summary for Hydroxypinacolone Retinoate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
direct-rar-binding
eye-area-safe
retinoid-synergy
2025-clinical-data
Frequently Asked Questions
Is Hydroxypinacolone Retinoate allowed in the EU?
Hydroxypinacolone Retinoate EU regulatory status: permitted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxypinacolone Retinoate do in cosmetics?
Hydroxypinacolone Retinoate functions as: skin-conditioning, anti-aging. It is classified as a Active Ingredient in our database. CAS number: 893412-73-2.
Compliance Tools
Check Hydroxypinacolone Retinoate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acetyl Tetrapeptide-5
EXCELLENT
Same category
Anti-edema peptide for periorbital ar...
Activated Charcoal
EXCELLENT
Same category
Adsorbent; skin cleanser; pore-cleans...
Adenosine
EXCELLENT
Same category
Skin-conditioning agent, anti-aging, ...
Allantoin
EXCELLENT
Same category
Skin conditioner, keratolytic, anti-i...
Alpha-Glucan Oligosaccharide
EXCELLENT
Same category
prebiotic, skin-conditioning
Ascophyllum Nodosum Extract
EXCELLENT
Same category
Skin Brightening, Tyrosinase Inhibito...
1-Methylhydantoin-2-imide (Creatinine)
EXCELLENT
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
EXCELLENT
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
EXCELLENT
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
EXCELLENT
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Antioxidant; tyrosinase inhibitor; me...
HYDRASTIS CANADENSIS EXTRACT
GOOD
Browse nearby
Fragrance, Skin Conditioning
HYDRATROPIC ALDEHYDE
GOOD
Browse nearby
Perfuming
HYDROCHLOROFLUOROCARBON 142B
GOOD
Browse nearby
Deodorant, Propellant
Is Hydroxypinacolone Retinoate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hydroxypinacolone Retinoate in your formulation.