Excellent Active Ingredient

Hydroxypinacolone Retinoate

INCI: HYDROXYPINACOLONE RETINOATE

CAS Number
893412-73-2
Function
skin-conditioning, anti-aging
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 0.5%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes OTC cosmetic ingredient; no CIR monograph; generally considered low-irritation retinoid

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Next-generation OTC retinoid ester that binds retinoid acid receptors directly without enzymatic conversion, providing immediate biological activity comparable to prescription retinoids with minimal irritation and suitability for sensitive areas including the eye region.

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Concern Level: Low

Regulatory Flags

direct-rar-binding eye-area-safe retinoid-synergy 2025-clinical-data

Frequently Asked Questions

Is Hydroxypinacolone Retinoate safe in cosmetics?

Next-generation OTC retinoid ester that binds retinoid acid receptors directly without enzymatic conversion, providing immediate biological activity comparable to prescription retinoids with minimal irritation and suitability for sensitive areas including the eye region. The EU classifies Hydroxypinacolone Retinoate as "permitted". Safety rating: EXCELLENT.

Is Hydroxypinacolone Retinoate allowed in the EU?

Hydroxypinacolone Retinoate EU regulatory status: permitted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxypinacolone Retinoate do in cosmetics?

Hydroxypinacolone Retinoate functions as: skin-conditioning, anti-aging. It is classified as a Active Ingredient in our database. CAS number: 893412-73-2.

What is the Margin of Safety for Hydroxypinacolone Retinoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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