Ilex Guayusa Leaf Extract

INCI: ILEX GUAYUSA LEAF EXTRACT

CAS Number
Not listed in CosIng; no cosmetic-specific CAS confirmed [^1_8]
Function
Skin protecting
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR 700; FDA GRAS Notice GRN-835 exists for food use (supports safety profile)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

High caffeine content requires concentration limits in formulation; GRAS status for food supports general safety; traditional Amazonian use history supports tolerability; caffeine levels should be specified on CoA.

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Concern Level: Low

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Ilex Guayusa Leaf Extract safe in cosmetics?

High caffeine content requires concentration limits in formulation; GRAS status for food supports general safety; traditional Amazonian use history supports tolerability; caffeine levels should be specified on CoA. The EU classifies Ilex Guayusa Leaf Extract as "permitted". Safety rating: GOOD.

Is Ilex Guayusa Leaf Extract allowed in the EU?

Ilex Guayusa Leaf Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ilex Guayusa Leaf Extract do in cosmetics?

Ilex Guayusa Leaf Extract functions as: Skin protecting. It is classified as a cosmetic ingredient in our database. CAS number: Not listed in CosIng; no cosmetic-specific CAS confirmed [^1_8].

What is the Margin of Safety for Ilex Guayusa Leaf Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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