NOAEL Studies
Cosmetic Ingredient
Imidazole NOAEL Studies
INCI: IMIDAZOLE
CAS: 288-32-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7e38df4a-ba11-44e5-950f-7feb5c49a956_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7e38df4a-ba11-44e5-950f-7feb5c49a956/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=25705657-913c-4269-82a3-8392bd3f0dde |
| ECHA | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7e38df4a-ba11-44e5-950f-7feb5c49a956_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7e38df4a-ba11-44e5-950f-7feb5c49a956/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=06a02bd2-cfba-4d44-9596-fe37cc5bc185 |
| ECHA | NOAEL | 60 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=a483e5da-2375-4a11-a66f-90ff48e99fad_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=a483e5da-2375-4a11-a66f-90ff48e99fad/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-09-05; basis=other:; key_result=false; entry_uuid=b1343f7d-0894-4446-a1a4-954cda1b673a |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=80ce8fb5-7553-435c-8986-ebddc3447c23_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=80ce8fb5-7553-435c-8986-ebddc3447c23/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2012; ReportDate=2012-12-10; basis=other:; key_result=false; entry_uuid=4a1ff9e1-5b2f-449d-b7b7-fbf3639fd08e |
| ECHA | NOAEL | 125 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=d29b8ed6-dc54-49ec-8faa-94388720cc48_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=d29b8ed6-dc54-49ec-8faa-94388720cc48/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=dff89e17-e6e3-450d-86a8-a94df0d7f5da |
| ECHA | NOAEL | 62.5 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=19f92c3c-fd2b-4e1a-9716-ffc0c92f9e99_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=19f92c3c-fd2b-4e1a-9716-ffc0c92f9e99/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-01-23; key_result=false; entry_uuid=4b143c8f-45da-4187-afcf-6cc7bacb3627 |
| ECHA | NOAEL | 90 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=bac6103c-ca1d-4e12-842b-7f8cafe11e29_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=bac6103c-ca1d-4e12-842b-7f8cafe11e29/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; ReportDate=2016-06-20; basis=other:; key_result=false; entry_uuid=02cd87d2-53f0-4dc6-8a16-e19a98603020 |
| ECHA | NOAEL | 30 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7ea0e201-ec81-466b-aa5b-e17b86fbbcdf_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7ea0e201-ec81-466b-aa5b-e17b86fbbcdf/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=b85a8906-fe74-4068-82cb-d616ea00215e |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =220 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_5071; row=4296; data_type=In Vivo; mixture=Chemical; chemical_name=Imidazole; preferred_name=Imidazole; dtxsid=DTXSID2029616; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10568; RecordID=ARPathway2016_1104; DatasetName=ARPathway2016; DTXSID=DTXSID2029616; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616 |
NTP ICE eye irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | Draize rabbit irritation score | 59.3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=793; Record_ID=eye_irritation_155; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=59.3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616 |
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=787; Record_ID=eye_irritation_80; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616 |
| NTP ICE eye irritation | Intensity | 0.26 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=791; Record_ID=eye_irritation_1293; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Vitrigel; Endpoint=Intensity; Response=0.26; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616 |
| NTP ICE eye irritation | Lag time | 100 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=792; Record_ID=eye_irritation_1293; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Vitrigel; Endpoint=Lag time; Response=100; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616 |
| NTP ICE eye irritation | Plateau level | 22 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=789; Record_ID=eye_irritation_1293; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Vitrigel; Endpoint=Plateau level; Response=22; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616 |
ToxValDB ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =30 | mg/L | Mouse | environmental | short-term; 2 days | reproduction developmental | LONG_REF=Teratology40(6): 555-566 Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors 1989; TITLE=Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors; AUTHOR=Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer; DOI=10.1002/tera.1420400603; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92257; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX:15597694:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ebc5f218f7e6d2b1863d1a51a4649b40 |
| ToxValDB ECOTOX | NOEL | =30 | mg/L | Mouse | environmental | short-term; 2 days | developmental | LONG_REF=Teratology40(6): 555-566 Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors 1989; TITLE=Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors; AUTHOR=Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer; DOI=10.1002/tera.1420400603; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92257; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Development: Abnormal|Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX:15595387:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=86e965b6568e74e13d0f9dc880d353b6 |
| ToxValDB ECOTOX | NOEL | =210 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Teratology40(6): 555-566 Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors 1989; TITLE=Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors; AUTHOR=Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer; DOI=10.1002/tera.1420400603; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92257; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Development: Abnormal|Morphology: Length|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601040_15601253:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=09f86fbe76aa62ed638a1a71c212211b |
| ToxValDB ECOTOX | NOEL | =60 | mg/L | Rat | environmental | short-term; 2 days | reproduction developmental | LONG_REF=Teratology40(6): 555-566 Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors 1989; TITLE=Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors; AUTHOR=Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer; DOI=10.1002/tera.1420400603; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92257; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15602124:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=183f2105cdc717bd83181f3c5e4cb1bf |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =10.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632768:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5248fb6b594a6b0a120ce6ccdb65ce58 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOAEL | =60 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0ddce4b0a676289ddfd9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Deaths: There were no substance-related deaths.|Urinalysis: Transitional epithelial cells increase|Blood Chemistry: Cl decrease, Glob decrease, TP decrease, Alb decrease|Relative Organ Weight: Liver increase, Kidney increase|Histopathology: Liver: Centrilobular hypertrophy Kidney: a2u-microglobulin accumulation, proximal epithelial and luminal tubule, diffuse; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=HESS:15638554:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8d50bc9d7dc8ba0c5c281feb2e642a4f |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 7GBN705NH1 | UNII | - | - | - | chemical | - |