NOAEL Studies Cosmetic Ingredient

Isopropyl Alcohol NOAEL Studies

INCI: ISOPROPYL ALCOHOL

CAS: 67-63-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 15 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
COSMOS DB	LOAEL	20	mg/kg bw/day	primate	oral	245 day	Subchronic	PAFA
COSMOS DB	LOAEL	480	mg/kg bw/day	rabbit	oral	6-18 Gestation day	Developmental	PAFA; Fundam Appl Toxicol 22: 139-151; 1994
COSMOS DB	NOAEL	7	mg/kg bw/day	rat	oral	84 day	Short Term Toxicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	20	mg/kg bw/day	monkey	oral	245 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	100	mg/kg bw/day	rat	oral	NA	Multigeneration Reproductive	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	240	mg/kg bw/day	rabbit	oral	6-18 Gestation day	Developmental	PAFA; Fundam Appl Toxicol 22: 139-151; 1994
COSMOS DB	NOAEL	466	mg/kg bw/day	rabbit	oral	13 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	480	mg/kg bw/day	rabbit	oral	13 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	601	mg/kg bw/day	rat	oral	1 day	Special Toxicology Study	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	625	mg/kg bw/day	rabbit	oral	13 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	800	mg/kg bw/day	rat	oral	37 day	Reproductive	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	1200	mg/kg bw/day	rat	oral	10 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	1250	mg/kg bw/day	rat	oral	NA	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	1280	mg/kg bw/day	rat	oral	10 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	2000	mg/kg bw/day	rat	oral	NA	Multigeneration Reproductive	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study

EFSA 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EFSA	NOAEL	=240	mg/kg bw/day	Rabbit	oral: gavage	13 days	reproduction toxicity	EFSA AFC - 2005 - OutputID 316 - mortality - reproductive - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Propan-2-ol as a carrier solvent for Flavourings - doi:10.2903/j.efsa.2005.202
EFSA	ADI	=2.4	mg/kg bw/day	Consumers	-	-	ADI	EFSA AFC - 2005 - OutputID 316 - Consumers - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Propan-2-ol as a carrier solvent for Flavourings - doi:10.2903/j.efsa.2005.202
EFSA	NOAEL	=240	mg/kg bw/day	Rabbit	oral	short-term; 13 days	reproduction developmental	LONG_REF=EFSA AFC (2005). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Propan-2-ol as a carrier solvent for Flavourings. doi:10.2903/j.efsa.2005.202.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Propan-2-ol as a carrier solvent for Flavourings; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2005.202; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA_dup_-_15614212_15614213:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2438909624666e90a6c990e153168682

IARC Monographs 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
IARC Monographs	IARC carcinogenicity classification	3	IARC group	-	-	1998	IARC Monographs	-

WHO/JECFA 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
WHO/JECFA	LOEL	=327	mg/m3	Rat	inhalation	-	Inhalation toxicity	document_id=ehc_ehc_ehc103; title=Propanol, 2- (EHC 103, 1990); path=mirror/documents/ehc/ehc/ehc103.htm; row_hash=f07da2c639de221c; raw_unit=mg/m 3; context=Inhalation exposure of pregnant rats to 2-propanol provided a lowest-observed-effect level (LOEL) of 18 327 mg/m 3 (7450 ppm) and a no-observed-effect level (NOEL) of 9001 mg/m 3 (3659 ppm) for maternal toxicity.
WHO/JECFA	NOEL	=3659	ppm	-	-	-	Developmental toxicity	document_id=ehc_ehc_ehc103; title=Propanol, 2- (EHC 103, 1990); path=mirror/documents/ehc/ehc/ehc103.htm; row_hash=5fec3c06737889cf; raw_unit=ppm; context=In the same study, 9001 mg/m 3 (3659 ppm) was a LOEL for developmental toxicity, with no demonstration of a NOEL.
WHO/JECFA	NOEL	=9001	mg/m3	Rat	inhalation	-	Inhalation toxicity	document_id=ehc_ehc_ehc103; title=Propanol, 2- (EHC 103, 1990); path=mirror/documents/ehc/ehc/ehc103.htm; row_hash=4dfba08d68f003c0; raw_unit=mg/m 3; context=Inhalation exposure of pregnant rats to 2-propanol provided a LOEL of 18 327 mg/m 3 (7450 ppm) and a NOEL of 9001 mg/m 3 (3659 ppm) for maternal toxicity.

NTP ICE acute dermal 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE acute dermal	EPA classification	4	unitless	Rat	Dermal	-	In Vivo; Rat Acute Dermal Toxicity	sheet=Data; excel_row=1721; Record_ID=acute_dermal_91; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID7020762; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE acute dermal	GHS classification	5	unitless	Rat	Dermal	-	In Vivo; Rat Acute Dermal Toxicity	sheet=Data; excel_row=1723; Record_ID=acute_dermal_91; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID7020762; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE acute dermal	LD50	>5050	mg/kg	Rat	Dermal	-	In Vivo; Rat Acute Dermal Toxicity	sheet=Data; excel_row=1722; Record_ID=acute_dermal_91; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID7020762; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5050.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762

NTP ICE acute inhalation 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE acute inhalation	EPA Classification	4	unitless	-	Inhalation	-	In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=3852; Record_ID=acute_inhalation_481; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID7020762; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE acute inhalation	LC50	>2.16	mg/L	-	Inhalation	-	In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=3855; Record_ID=acute_inhalation_481; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID7020762; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.16; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE acute inhalation	LC50	39.3022	mg/L	-	Inhalation	Duration=8 hr	In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=3854; Record_ID=acute_inhalation_976; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=39.3022; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE acute inhalation	LC50	72.6	mg/L	-	Inhalation	-	In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=3856; Record_ID=acute_inhalation_1702; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=72.6; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762

NTP ICE acute oral 8 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE acute oral	EPA classification	=4	Unitless	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12331; row=11593; data_type=In Vivo; mixture=Mixture; formulation_id=MIX90; formulation_name=Cavicide 1; chemical_name=Isopropyl alcohol; preferred_name=Isopropanol; percent_active_ingredient=15.0; dtxsid=DTXSID7020762; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020762; source_file=acute_oral.xlsx
NTP ICE acute oral	GHS classification	=5	Unitless	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12331; row=11594; data_type=In Vivo; mixture=Mixture; formulation_id=MIX90; formulation_name=Cavicide 1; chemical_name=Isopropyl alcohol; preferred_name=Isopropanol; percent_active_ingredient=15.0; dtxsid=DTXSID7020762; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020762; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=4710	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9184; row=11587; data_type=In Vivo; mixture=Chemical; chemical_name=Isopropanol; preferred_name=Isopropanol; dtxsid=DTXSID7020762; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020762; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	>5000	mg/kg bw	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12331; row=11592; data_type=In Vivo; mixture=Mixture; formulation_id=MIX90; formulation_name=Cavicide 1; chemical_name=Isopropyl alcohol; preferred_name=Isopropanol; percent_active_ingredient=15.0; dtxsid=DTXSID7020762; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020762; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=5045	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9186; row=11588; data_type=In Vivo; mixture=Chemical; chemical_name=Isopropanol; preferred_name=Isopropanol; dtxsid=DTXSID7020762; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020762; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=5280	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9188; row=11589; data_type=In Vivo; mixture=Chemical; chemical_name=Isopropanol; preferred_name=Isopropanol; dtxsid=DTXSID7020762; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020762; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=5500	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9190; row=11590; data_type=In Vivo; mixture=Chemical; chemical_name=Isopropanol; preferred_name=Isopropanol; dtxsid=DTXSID7020762; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020762; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=5840	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9192; row=11591; data_type=In Vivo; mixture=Chemical; chemical_name=Isopropanol; preferred_name=Isopropanol; dtxsid=DTXSID7020762; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7020762; source_file=acute_oral.xlsx

NTP ICE adme parameters 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE adme parameters	Clint	1.102	uL/min/10^6 cells	Human	-	-	Measured; httk, Human Hepatic Intrinsic Clearance	sheet=Data; excel_row=2721; Record_ID=adme_parameters_1187; Data_Type=Measured; DTXSID=DTXSID7020762; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=1.102; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE adme parameters	Clint	5.972	uL/min/10^6 cells	Rat	-	-	Measured; httk, Rat Hepatic Intrinsic Clearance	sheet=Data; excel_row=2722; Record_ID=adme_parameters_1187; Data_Type=Measured; DTXSID=DTXSID7020762; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=5.972; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE adme parameters	Fu	0.6696	fraction	Rat	-	-	Measured; httk, Rat Plasma Fraction Unbound	sheet=Data; excel_row=2720; Record_ID=adme_parameters_1187; Data_Type=Measured; DTXSID=DTXSID7020762; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.6696; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE adme parameters	Fu	0.9214	fraction	Human	-	-	Measured; httk, Human Plasma Fraction Unbound	sheet=Data; excel_row=2719; Record_ID=adme_parameters_1187; Data_Type=Measured; DTXSID=DTXSID7020762; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.9214; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762

NTP ICE cancer 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE cancer	IARC group	3	unitless	-	-	-	WOE; IARC Carcinogenicity	sheet=Data; excel_row=7661; Record_ID=cancer_3188; Data_Type=WOE; Formulation_Name=Isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/33; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762

NTP ICE eye irritation 6 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE eye irritation	Draize rabbit irritation score	30.5	unitless	Rabbit	Ocular	-	In Vivo; Draize Eye Irritation/Corrosion Test	sheet=Data; excel_row=2013; Record_ID=eye_irritation_137; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=30.5; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE eye irritation	EPA Classification	3	unitless	Rabbit	Ocular	-	In Vivo; Draize Eye Irritation/Corrosion Test	sheet=Data; excel_row=2008; Record_ID=eye_irritation_137; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE eye irritation	GHS Classification	2	unitless	Rabbit	Ocular	-	In Vivo; Draize Eye Irritation/Corrosion Test	sheet=Data; excel_row=2009; Record_ID=eye_irritation_137; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE eye irritation	Intensity	0.3	%/sec	-	Ocular	-	In Vitro; Vitrigel	sheet=Data; excel_row=2012; Record_ID=eye_irritation_1281; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Vitrigel; Endpoint=Intensity; Response=0.3; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE eye irritation	Lag time	0	s	-	Ocular	-	In Vitro; Vitrigel	sheet=Data; excel_row=2010; Record_ID=eye_irritation_1281; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE eye irritation	Plateau level	27	%	-	Ocular	-	In Vitro; Vitrigel	sheet=Data; excel_row=2016; Record_ID=eye_irritation_1281; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Vitrigel; Endpoint=Plateau level; Response=27; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762

NTP ICE skin irritation 34 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE skin irritation	EPA classification	4	unitless	Rabbit	Dermal	-	In Vivo; Draize Skin Irritation/Corrosion Test	sheet=Data_invivo; excel_row=1341; Record_ID=skin_irritation_invivo_713; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=15; Mixture=Mixture; DTXSID=DTXSID7020762; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male/Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Positive reaction	0	%	Human	Dermal	-	In Vivo; Four-hour Human Patch Test	sheet=Data_invivo; excel_row=1342; Record_ID=skin_irritation_invivo_29; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	74.2	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4552; Record_ID=skin_irritation_invitro_1129; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=74.2; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	80.46	%	-	Dermal	-	In Vitro; EpiSkin Irritation	sheet=Data_invitro; excel_row=4553; Record_ID=skin_irritation_invitro_1130; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Irritation; Endpoint=Viability; Response=80.46; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	80.7	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4554; Record_ID=skin_irritation_invitro_1131; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=80.7; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	81.2	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4555; Record_ID=skin_irritation_invitro_1132; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=81.2; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	82.7	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4562; Record_ID=skin_irritation_invitro_1215; Data_Type=In Vitro; Formulation_Name=Isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=82.7; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	83.5	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4563; Record_ID=skin_irritation_invitro_1217; Data_Type=In Vitro; Formulation_Name=Isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=83.5; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	84.8	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4556; Record_ID=skin_irritation_invitro_1133; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=84.8; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	85.07	%	-	Dermal	-	In Vitro; EpiDerm Irritation	sheet=Data_invitro; excel_row=4557; Record_ID=skin_irritation_invitro_1134; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiDerm Irritation; Endpoint=Viability; Response=85.07; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	86.96	%	-	Dermal	-	In Vitro; EpiSkin Irritation	sheet=Data_invitro; excel_row=4547; Record_ID=skin_irritation_invitro_1089; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Irritation; Endpoint=Viability; Response=86.96; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	87.7	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4564; Record_ID=skin_irritation_invitro_1219; Data_Type=In Vitro; Formulation_Name=Isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=87.7; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	87.8	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4548; Record_ID=skin_irritation_invitro_1091; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=87.8; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	89.7	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4549; Record_ID=skin_irritation_invitro_1094; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=89.7; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	92.1	%	-	Dermal	-	In Vitro; LabCyte EPI-MODEL24 Irritation	sheet=Data_invitro; excel_row=4550; Record_ID=skin_irritation_invitro_1096; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=92.1; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	93.4	%	-	Dermal	-	In Vitro; EpiDerm Irritation	sheet=Data_invitro; excel_row=4565; Record_ID=skin_irritation_invitro_1220; Data_Type=In Vitro; Formulation_Name=Isopropanol; Concentration=99.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiDerm Irritation; Endpoint=Viability; Response=93.4; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	93.94	%	-	Dermal	-	In Vitro; EpiDerm Irritation	sheet=Data_invitro; excel_row=4551; Record_ID=skin_irritation_invitro_1098; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiDerm Irritation; Endpoint=Viability; Response=93.94; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	97.1	%	-	Dermal	-	In Vitro; EpiDerm Irritation	sheet=Data_invitro; excel_row=4566; Record_ID=skin_irritation_invitro_1221; Data_Type=In Vitro; Formulation_Name=Isopropanol; Concentration=99.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiDerm Irritation; Endpoint=Viability; Response=97.1; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	97.45	%	-	Dermal	-	In Vitro; EpiSkin Irritation	sheet=Data_invitro; excel_row=4558; Record_ID=skin_irritation_invitro_1207; Data_Type=In Vitro; Formulation_Name=Isopropanol; Concentration=99.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Irritation; Endpoint=Viability; Response=97.45; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	97.88	%	-	Dermal	-	In Vitro; EpiDerm Irritation	sheet=Data_invitro; excel_row=4559; Record_ID=skin_irritation_invitro_1209; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiDerm Irritation; Endpoint=Viability; Response=97.88; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	100.41	%	-	Dermal	-	In Vitro; EpiSkin Irritation	sheet=Data_invitro; excel_row=4560; Record_ID=skin_irritation_invitro_1211; Data_Type=In Vitro; Formulation_Name=isopropanol; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Irritation; Endpoint=Viability; Response=100.41; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	104.63	%	-	Dermal	-	In Vitro; EpiSkin Irritation	sheet=Data_invitro; excel_row=4561; Record_ID=skin_irritation_invitro_1213; Data_Type=In Vitro; Formulation_Name=Isopropanol; Concentration=99.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Irritation; Endpoint=Viability; Response=104.63; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability	109.2	%	-	Dermal	-	In Vitro; EpiDerm Irritation	sheet=Data_invitro; excel_row=4567; Record_ID=skin_irritation_invitro_1222; Data_Type=In Vitro; Formulation_Name=Isopropanol; Concentration=99.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiDerm Irritation; Endpoint=Viability; Response=109.2; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (18 hours)	89.5	%	-	Dermal	-	In Vitro; Vitrolife-Skin Irritation	sheet=Data_invitro; excel_row=4543; Record_ID=skin_irritation_invitro_206; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=89.5; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (240 minutes)	80.8	%	-	Dermal	-	In Vitro; EpiSkin Corrosion	sheet=Data_invitro; excel_row=4598; Record_ID=skin_irritation_invitro_2057; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=80.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (240 minutes)	88.5	%	-	Dermal	-	In Vitro; EpiSkin Corrosion	sheet=Data_invitro; excel_row=4599; Record_ID=skin_irritation_invitro_2055; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=88.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (240 minutes)	94.7	%	-	Dermal	-	In Vitro; EpiSkin Corrosion	sheet=Data_invitro; excel_row=4597; Record_ID=skin_irritation_invitro_2059; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=94.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (3 minutes)	91.8	%	-	Dermal	-	In Vitro; EpiSkin Corrosion	sheet=Data_invitro; excel_row=4603; Record_ID=skin_irritation_invitro_2057; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=91.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (3 minutes)	98.1	%	-	Dermal	-	In Vitro; EpiSkin Corrosion	sheet=Data_invitro; excel_row=4602; Record_ID=skin_irritation_invitro_2059; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=98.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (3 minutes)	98.9	%	-	Dermal	-	In Vitro; EpiSkin Corrosion	sheet=Data_invitro; excel_row=4604; Record_ID=skin_irritation_invitro_2055; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=98.9; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (42 hours)	84.8	%	-	Dermal	-	In Vitro; Vitrolife-Skin Irritation	sheet=Data_invitro; excel_row=4545; Record_ID=skin_irritation_invitro_206; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=84.8; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (60 minutes)	84.4	%	-	Dermal	-	In Vitro; EpiSkin Corrosion	sheet=Data_invitro; excel_row=4601; Record_ID=skin_irritation_invitro_2055; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=84.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (60 minutes)	87.8	%	-	Dermal	-	In Vitro; EpiSkin Corrosion	sheet=Data_invitro; excel_row=4581; Record_ID=skin_irritation_invitro_2057; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=87.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin irritation	Viability (60 minutes)	100.2	%	-	Dermal	-	In Vitro; EpiSkin Corrosion	sheet=Data_invitro; excel_row=4600; Record_ID=skin_irritation_invitro_2059; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=100.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762

NTP ICE skin sensitization 61 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE skin sensitization	CD86, EC150	>200	ug/mL	-	Dermal	-	In Vitro; CE_USENSE2018; U-SENS	sheet=Data_invitro; excel_row=8724; Record_ID=skin_sensitization_invitro_2417; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	CD86, EC150	>420.672	ug/mL	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; U-SENS	sheet=Data_invitro; excel_row=8188; Record_ID=skin_sensitization_invitro_2211; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=60.096; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=420.672; Converted_Response_Unit=ug/mL; Response=420.672; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	CV75	2000	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2851; Record_ID=skin_sensitization_invitro_673; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=h-CLAT; Endpoint=CV75; Reported_Response=2000; Reported_Response_Unit=ug/mL; Response=2000; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	CV75	>5000	ug/mL	-	Dermal	-	In Vitro; CE_hCLAT2018; h-CLAT	sheet=Data_invitro; excel_row=2252; Record_ID=skin_sensitization_invitro_553; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=h-CLAT; Endpoint=CV75; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=5000; Reported_Response_Unit=ug/mL; Response=5000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	-10	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=650; Record_ID=skin_sensitization_invitro_186; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-10; Reported_Response_Unit=%; Response=-10; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064\|Jaworska 2011; 23670904; 10.1002/jat.2869\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	-2	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=630; Record_ID=skin_sensitization_invitro_181; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-2; Reported_Response_Unit=%; Response=-2; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	0.3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=662; Record_ID=skin_sensitization_invitro_189; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.3; Reported_Response_Unit=%; Response=0.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	1	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=666; Record_ID=skin_sensitization_invitro_190; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=1; Reported_Response_Unit=%; Response=1; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	1.5	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=674; Record_ID=skin_sensitization_invitro_192; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=1.5; Reported_Response_Unit=%; Response=1.5; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	5	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=646; Record_ID=skin_sensitization_invitro_185; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=5; Reported_Response_Unit=%; Response=5; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	6.1	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=670; Record_ID=skin_sensitization_invitro_191; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=6.1; Reported_Response_Unit=%; Response=6.1; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	9.3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=654; Record_ID=skin_sensitization_invitro_187; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=9.3000000000000007; Reported_Response_Unit=%; Response=9.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	9.9	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=634; Record_ID=skin_sensitization_invitro_182; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=9.9; Reported_Response_Unit=%; Response=9.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Cys	10.8	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=658; Record_ID=skin_sensitization_invitro_188; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=10.8; Reported_Response_Unit=%; Response=10.8; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys	-1.7	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=629; Record_ID=skin_sensitization_invitro_181; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-1.7; Reported_Response_Unit=%; Response=-1.7; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys	0.2	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=653; Record_ID=skin_sensitization_invitro_187; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.2; Reported_Response_Unit=%; Response=0.2; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys	0.5	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=633; Record_ID=skin_sensitization_invitro_182; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.5; Reported_Response_Unit=%; Response=0.5; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys	0.6	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=665; Record_ID=skin_sensitization_invitro_190; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.6; Reported_Response_Unit=%; Response=0.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys	0.7	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=657; Record_ID=skin_sensitization_invitro_188; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.7; Reported_Response_Unit=%; Response=0.7; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys	0.9	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=677; Record_ID=skin_sensitization_invitro_193; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.9; Reported_Response_Unit=%; Response=0.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys	2.3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=645; Record_ID=skin_sensitization_invitro_185; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.2999999999999998; Reported_Response_Unit=%; Response=2.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys	2.8	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=689; Record_ID=skin_sensitization_invitro_196; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.8; Reported_Response_Unit=%; Response=2.8; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006\|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	0	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=631; Record_ID=skin_sensitization_invitro_181; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	0.25	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=651; Record_ID=skin_sensitization_invitro_186; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.25; Reported_Response_Unit=%; Response=0.25; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064\|Jaworska 2011; 23670904; 10.1002/jat.2869\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	0.4	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=663; Record_ID=skin_sensitization_invitro_189; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.4; Reported_Response_Unit=%; Response=0.4; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	0.45	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=679; Record_ID=skin_sensitization_invitro_193; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.45; Reported_Response_Unit=%; Response=0.45; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	0.8	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=667; Record_ID=skin_sensitization_invitro_190; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.8; Reported_Response_Unit=%; Response=0.8; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	0.85	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=675; Record_ID=skin_sensitization_invitro_192; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.85; Reported_Response_Unit=%; Response=0.85; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	1.4	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=691; Record_ID=skin_sensitization_invitro_196; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.4; Reported_Response_Unit=%; Response=1.4; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006\|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	3.05	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=671; Record_ID=skin_sensitization_invitro_191; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=3.05; Reported_Response_Unit=%; Response=3.05; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	3.65	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=647; Record_ID=skin_sensitization_invitro_185; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=3.65; Reported_Response_Unit=%; Response=3.65; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	4.75	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=655; Record_ID=skin_sensitization_invitro_187; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=4.75; Reported_Response_Unit=%; Response=4.75; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	5.2	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=635; Record_ID=skin_sensitization_invitro_182; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=5.2; Reported_Response_Unit=%; Response=5.2; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Depletion Lys + Cys	5.75	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=659; Record_ID=skin_sensitization_invitro_188; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=5.75; Reported_Response_Unit=%; Response=5.75; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	EC1.5	>2000	uM	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=6450; Record_ID=skin_sensitization_invitro_1539; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868\|Joint Research Centre of the European Union 2014\|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	IC50	>3000	uM	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; LuSens	sheet=Data_invitro; excel_row=7636; Record_ID=skin_sensitization_invitro_1804; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=3000; Reported_Response_Unit=uM; Response=3000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6494; Record_ID=skin_sensitization_invitro_1540; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1; Reported_Response_Unit=Unitless; Response=1; Response_Unit=Ratio; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.006	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6495; Record_ID=skin_sensitization_invitro_1538; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.006; Reported_Response_Unit=Unitless; Response=1.006; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.1	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6496; Record_ID=skin_sensitization_invitro_1528; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1000000000000001; Reported_Response_Unit=Unitless; Response=1.1; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.107	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6497; Record_ID=skin_sensitization_invitro_1531; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.107; Reported_Response_Unit=Unitless; Response=1.107; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.151	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6498; Record_ID=skin_sensitization_invitro_1541; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.151; Reported_Response_Unit=Unitless; Response=1.151; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.17	ratio	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=6499; Record_ID=skin_sensitization_invitro_1539; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.17; Reported_Response_Unit=Unitless; Response=1.17; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868\|Joint Research Centre of the European Union 2014\|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.182	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6500; Record_ID=skin_sensitization_invitro_1532; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1819999999999999; Reported_Response_Unit=Unitless; Response=1.182; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.196	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6501; Record_ID=skin_sensitization_invitro_1542; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.196; Reported_Response_Unit=Unitless; Response=1.196; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.198	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6502; Record_ID=skin_sensitization_invitro_1537; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.198; Reported_Response_Unit=Unitless; Response=1.198; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.2	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6503; Record_ID=skin_sensitization_invitro_1519; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2; Reported_Response_Unit=Unitless; Response=1.2; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.212	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6504; Record_ID=skin_sensitization_invitro_1521; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.212; Reported_Response_Unit=Unitless; Response=1.212; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.233	ratio	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; LuSens	sheet=Data_invitro; excel_row=7538; Record_ID=skin_sensitization_invitro_1804; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LuSens; Endpoint=Imax; Reported_Response=1.233182024; Reported_Response_Unit=Unitless; Response=1.233; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.241	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6505; Record_ID=skin_sensitization_invitro_1522; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2410000000000001; Reported_Response_Unit=Unitless; Response=1.241; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.248	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6506; Record_ID=skin_sensitization_invitro_1535; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.248; Reported_Response_Unit=Unitless; Response=1.248; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.258	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6507; Record_ID=skin_sensitization_invitro_1520; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.258; Reported_Response_Unit=Unitless; Response=1.258; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.286	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6508; Record_ID=skin_sensitization_invitro_1530; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.286; Reported_Response_Unit=Unitless; Response=1.286; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.3	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6510; Record_ID=skin_sensitization_invitro_1524; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.3; Reported_Response_Unit=Unitless; Response=1.3; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.329	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6514; Record_ID=skin_sensitization_invitro_1523; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.329; Reported_Response_Unit=Unitless; Response=1.329; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.4	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6516; Record_ID=skin_sensitization_invitro_1526; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4; Reported_Response_Unit=Unitless; Response=1.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.41	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6518; Record_ID=skin_sensitization_invitro_1529; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.41; Reported_Response_Unit=Unitless; Response=1.41; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.419	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6520; Record_ID=skin_sensitization_invitro_1536; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.419; Reported_Response_Unit=Unitless; Response=1.419; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.5	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6521; Record_ID=skin_sensitization_invitro_1527; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.5; Reported_Response_Unit=Unitless; Response=1.5; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.879	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6522; Record_ID=skin_sensitization_invitro_1533; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.879; Reported_Response_Unit=Unitless; Response=1.879; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Imax	1.945	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6523; Record_ID=skin_sensitization_invitro_1534; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.9450000000000001; Reported_Response_Unit=Unitless; Response=1.945; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762
NTP ICE skin sensitization	Max stimulation index	1.7	ratio	Mouse	Dermal	-	In Vivo; LLNA2013; LLNA	sheet=Data_invivo; excel_row=12845; Record_ID=skin_sensitization_invivo_482; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID7020762; Assay=LLNA; Endpoint=Max stimulation index; Response=1.7; Response_Unit=Ratio; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020762; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020762

ToxValDB Cal OEHHA REL derivations 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB Cal OEHHA REL derivations	NOAEL	=491.585	mg/m3	Human	inhalation	acute; 5 minutes	clinical	LONG_REF=Nelson KW, Ege JF Jr, Ross M, Woodman LE, Silverman L. Sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 1943;25(7):282-285; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=Cal OEHHA REL derivations:15951945:-:-subjects; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d54d7567e32ad1f08605cdbd415fc0aa
ToxValDB Cal OEHHA REL derivations	NOAEL	=1238.79	mg/m3	Mouse	inhalation	chronic; 78 weeks	chronic	LONG_REF=Burleigh-Flayer H, Garman R, Neptun D, Bevan C, Gardiner T, Kapp R, Tyler T, Wright G. 1997. Isopropanol vapor inhalation oncogenicity study in Fischer 344 rats and CD-1 mice. Fundam. Appl. Toxicol. 36(2):95-111.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Kidney lesions in mice and rats; STUDY_GROUP=Cal OEHHA REL derivations:15952094:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c4477044494dc3205c45a37273d1cf83

ToxValDB DOE Protective Action Criteria 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB DOE Protective Action Criteria	LEL	=49158.5	mg/m3	Human	inhalation	-	acute	LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15516412:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66e74cf22f57d2f0e698334896909e26

ToxValDB ECOTOX 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB ECOTOX	NOEL	=10	mmol/kg	Rat	oral	short-term; 1.75 days	short-term	LONG_REF=Fundam. Appl. Toxicol.15(3): 429-440 Ray,S.D., and H.M. Mehendale Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols 1990; TITLE=Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols; AUTHOR=Ray,S.D., and H.M. Mehendale; DOI=10.1016/0272-0590(90)90029-j; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=78954; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)\|Enzyme(s): Aspartate aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15596285:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8785234a4fa07b10dfbb367c7b7747af

ToxValDB GESTIS DNEL 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB GESTIS DNEL	DNEL systemic	=500	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634350:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3e4ccc3bb794efc1166bbc7011f2606

ToxValDB PPRTV (CPHEA) 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB PPRTV (CPHEA)	BMDL (05 HED)	=55.2	mg/kg bw/day	Rabbit	oral	short-term (developmental); 13 days	reproduction developmental	LONG_REF=Tyl et al. 1994; AUTHOR=Tyl et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1775; TOXICOLOGICAL_EFFECT=reduced fetal body weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=PPRTV (CPHEA):15654009:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_04fc4988e1c167458c9e604faab3570f
ToxValDB PPRTV (CPHEA)	LOAEL (HEC)	=221	mg/m3	Mouse	inhalation	chronic; 78 weeks	chronic	LONG_REF=Burleigh-Flayer et al. 1997; AUTHOR=Burleigh-Flayer et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1775; TOXICOLOGICAL_EFFECT=reduced absolute and relative testes weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=PPRTV (CPHEA):15653657:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_51e09262a52c564f0f6793445c604788
ToxValDB PPRTV (CPHEA)	NOAEL (HEC)	=662.3	mg/m3	Rat	inhalation	subchronic; 13 weeks	subchronic	LONG_REF=Burleigh-Flayer et al. 1994; AUTHOR=Burleigh-Flayer et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1775; TOXICOLOGICAL_EFFECT=increased mean motor activity; STUDY_GROUP=PPRTV (CPHEA):15653659:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c708a622946d3de3f21024a975ac0dfe
ToxValDB PPRTV (CPHEA)	RfC (provisional)	=7	mg/m3	Human	inhalation	-	Toxicity Value	LONG_REF=Burleigh-Flayer et al. 1994; AUTHOR=Burleigh-Flayer et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1775; TOXICOLOGICAL_EFFECT=Increased mean cumulative motor activity in female rats; STUDY_GROUP=PPRTV (CPHEA):15653658:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_00c54ea075f1edd15da0cbd6f01f1543

ToxValDB Pennsylvania DEP ToxValues 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB Pennsylvania DEP ToxValues	RfC	=0.2	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650314:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_404bc4f69f7014830930a04f546ddf94
ToxValDB Pennsylvania DEP ToxValues	RfD	=2	mg/kg bw/day	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650313:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ebee1e519c3b95f218b0b8e083401cbc

openFDA substances 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	ND2M416302	UNII	-	-	-	chemical	-