Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Isopropyl Myristate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | >1000 mg/kg bw/day | oral | rat | oral | REACH |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Isopropyl Myristate, relevant to systemic exposure and MoS calculations.
Source: CIR
Expert Verdict
Widely used lightweight penetration-enhancing emollient ester with well-established safety profile (CIR reviewed). Synthetically defined structure provides batch consistency superior to natural oils. Penetration enhancement via disruption of lamellar lipid organization is relevant for active delivery but increases TEWL potential. Key formulation restriction: comedogenic in sensitive/acne-prone individuals due to increased follicular lipid load; avoid or limit in acne-prone skin formulations. Prefer non-comedogenic alternatives for those applications.
Regulatory Flags
Frequently Asked Questions
Is Isopropyl Myristate safe in cosmetics?
Widely used lightweight penetration-enhancing emollient ester with well-established safety profile (CIR reviewed). Synthetically defined structure provides batch consistency superior to natural oils. Penetration enhancement via disruption of lamellar lipid organization is relevant for active delivery but increases TEWL potential. Key formulation restriction: comedogenic in sensitive/acne-prone individuals due to increased follicular lipid load; avoid or limit in acne-prone skin formulations. Prefer non-comedogenic alternatives for those applications. The EU classifies Isopropyl Myristate as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Isopropyl Myristate allowed in the EU?
Isopropyl Myristate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropyl Myristate do in cosmetics?
Isopropyl Myristate functions as: Isopropyl ester of myristic acid (C14:0). Lightweight penetration-enhancing emollient with low viscosity. Functions as emollient, skin-conditioning agent, penetration enhancer, and formulation carrier. Synthetically defined with excellent batch-to-batch consistency versus natural oils. Widely used in rinse-off and leave-on formulations as a carrier for lipophilic actives.. It is classified as a Emollient in our database. CAS number: 110-27-0.
What is the Margin of Safety for Isopropyl Myristate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isopropyl Myristate?
The NOAEL (No Observed Adverse Effect Level) for Isopropyl Myristate is >1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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